Anti-Trypanosoma cruzi TS/Trans-sialidase Antibody (13G9)

Catalog No.

RXX53801

Species reactivity

Trypanosoma cruzi

Host species

Human

Isotype

IgG1

Clonality

Monoclonal

Target

Trans-sialidase

Concentration

1 mg/ml

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

Q26966

Applications

IF, SPR

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Clone ID

13G9

A Trypanosoma cruzi Trans-Sialidase Peptide Demonstrates High Serological Prevalence Among Infected Populations Across Endemic Regions of Latin America., PMID:39974016

Trypanosoma cruzi has Two Peptidyl-tRNA Hydrolases Showing Different Localization and Function., PMID:39945942

Trypanosoma cruzi infection in American black bears (Ursus americanus): A case report in a cub from California and serologic survey for exposure in wild black bears from several states., PMID:39550185

ASP-2/Trans-sialidase chimeric protein induces robust protective immunity in experimental models of Chagas' disease., PMID:37258518

Intranasal trans-sialidase-based vaccine against Trypanosoma cruzi triggers a mixed cytokine profile in the nasopharynx-associated lymphoid tissue and confers local and systemic immunogenicity., PMID:36893830

Use of Leishmania major parasites expressing a recombinant Trypanosoma cruzi antigen as live vaccines against Chagas disease., PMID:36523834

Molecular Recognition of Surface Trans-Sialidases in Extracellular Vesicles of the Parasite Trypanosoma cruzi Using Atomic Force Microscopy (AFM)., PMID:35806197

Nasal immunization with a L. lactis-derived trans-sialidase antigen plus c-di-AMP protects against acute oral T. cruzi infection., PMID:35279330

Disruption of Active Trans-Sialidase Genes Impairs Egress from Mammalian Host Cells and Generates Highly Attenuated Trypanosoma cruzi Parasites., PMID:35073735

Effect of the Tc13Tul antigen from Trypanosoma cruzi on splenocytes from naïve mice., PMID:32466805

Diagnostic Applicability of Neutralizing Antibodies to Trypanosoma cruzi Trans-sialidase., PMID:30868532

Metabolic Labeling of Surface Neo-sialylglyconjugates Catalyzed by Trypanosoma cruzi trans-Sialidase., PMID:30868524

Trans-sialidase-based vaccine candidate protects against Trypanosoma cruzi infection, not only inducing an effector immune response but also affecting cells with regulatory/suppressor phenotype., PMID:28938533

Trypanosoma cruzi trans-sialidase prevents elicitation of Th1 cell response via interleukin 10 and downregulates Th1 effector cells., PMID:25754197

Efficacy of a trans-sialidase-ISCOMATRIX subunit vaccine candidate to protect against experimental Chagas disease., PMID:25625671

Prokineticin receptor identified by phage display is an entry receptor for Trypanosoma cruzi into mammalian cells., PMID:25324134

Trans-sialidase inhibition assay detects Trypanosoma cruzi infection in different wild mammal species., PMID:23930975

Trans-sialidase from Trypanosoma cruzi enhances the adhesion properties and fibronectin-driven migration of thymocytes., PMID:23481510

Differential immune response in mice immunized with the A, R or C domain from TcSP protein of Trypanosoma cruzi or with the coding DNAs., PMID:23106492

Trypanosoma cruzi trans-sialidase in complex with a neutralizing antibody: structure/function studies towards the rational design of inhibitors., PMID:22241998

Co-administration of a plasmid DNA encoding IL-15 improves long-term protection of a genetic vaccine against Trypanosoma cruzi., PMID:21408124

Intranasal vaccinations with the trans-sialidase antigen plus CpG Adjuvant induce mucosal immunity protective against conjunctival Trypanosoma cruzi challenges., PMID:20048046

Strain-specific protective immunity following vaccination against experimental Trypanosoma cruzi infection., PMID:19635607

Sialylated ligands on pathogenic Trypanosoma cruzi interact with Siglec-E (sialic acid-binding Ig-like lectin-E)., PMID:19552697

Molecular analysis of surface glycoprotein multigene family TrGP expressed on the plasma membrane of Trypanosoma rangeli epimastigotes forms., PMID:19433050

Trypanosoma cruzi: parasite shed vesicles increase heart parasitism and generate an intense inflammatory response., PMID:19028594

Auto-antibodies to receptor tyrosine kinases TrkA, TrkB and TrkC in patients with chronic Chagas' disease., PMID:18410251

Immunization with an engineered mutant trans-sialidase highly protects mice from experimental Trypanosoma cruzi infection: a vaccine candidate., PMID:18403070

Cloning and expression of trypanothione reductase from a New World Leishmania species., PMID:18060667

Nonradioactive trans-sialidase screening assay., PMID:17072006

Long-term protective immunity induced against Trypanosoma cruzi infection after vaccination with recombinant adenoviruses encoding amastigote surface protein-2 and trans-sialidase., PMID:16972758

Parasite-derived trans-sialidase binds to heart tissue in Trypanosoma cruzi-infected animals., PMID:15519048

Protective immunity against trypanosoma cruzi infection in a highly susceptible mouse strain after vaccination with genes encoding the amastigote surface protein-2 and trans-sialidase., PMID:15353042

Genetic immunization with LYT1 or a pool of trans-sialidase genes protects mice from lethal Trypanosoma cruzi infection., PMID:12798651

Parasite polymorphism may serve to enhance fitness in different host environments., PMID:12656128

Genetic immunization elicits antigen-specific protective immune responses and decreases disease severity in Trypanosoma cruzi infection., PMID:12228281

A functional network of intramolecular cross-reacting epitopes delays the elicitation of neutralizing antibodies to Trypanosoma cruzi trans-sialidase., PMID:12134236

Thymocyte depletion in Trypanosoma cruzi infection is mediated by trans-sialidase-induced apoptosis on nurse cells complex., PMID:11891302

The Trypanosoma cruzi trans-sialidase is a T cell-independent B cell mitogen and an inducer of non-specific Ig secretion., PMID:11867566

DNA sequences encoding CD4+ and CD8+ T-cell epitopes are important for efficient protective immunity induced by DNA vaccination with a Trypanosoma cruzi gene., PMID:11500420

Chagasic patients develop a type 1 immune response to Trypanosoma cruzi trans-sialidase., PMID:10607290

Trans-sialidase delivered as a naked DNA vaccine elicits an immunological response similar to a Trypanosoma cruzi infection., PMID:10347760

Comparison of antibody and protective immune responses against Trypanosoma cruzi infection elicited by immunization with a parasite antigen delivered as naked DNA or recombinant protein., PMID:10101720

Invasive phenotype of Trypanosoma cruzi restricted to a population expressing trans-sialidase., PMID:8751943

Purification and characterization of a trypanothione-glutathione thioltransferase from Trypanosoma cruzi., PMID:7654179

Trypanosoma brucei dihydrofolate reductase-thymidylate synthase: gene isolation and expression and characterization of the enzyme., PMID:8538681

Circulating trans-sialidase activity and trans-sialidase-inhibiting antibodies in Trypanosoma cruzi-infected mice., PMID:7479647

Mice infected with Trypanosoma cruzi produce antibodies against the enzymatic domain of trans-sialidase that inhibit its activity., PMID:8039915

Participation of autonomic nervous system in the pathogenesis of Chagas disease., PMID:7549008

Involvement of beta 1 integrins in the binding and entry of Trypanosoma cruzi into human macrophages., PMID:8436186

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