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Anti-Human MICA Antibody (13A9)

Catalog #:   RHH45203 Specific References (50) DATASHEET
Host species: Mouse
Isotype: IgG2a, kappa
Applications: ELISA, FCM
Accession: Q29983
Overview

Catalog No.

RHH45203

Species reactivity

Human

Host species

Mouse

Isotype

IgG2a, kappa

Clonality

Monoclonal

Target

MHC class I polypeptide-related sequence A, MIC-A, MICA, PERB11.1

Concentration

1 mg/ml

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

Q29983

Applications

ELISA, FCM

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Clone ID

13A9

Data Image
References

Two major human phenotypes of MICA molecules and their differential activation to NK cells via NKG2D receptor., PMID:40458406

Insights into pathophysiology, biomarkers, and therapeutics in tauopathies: Proceedings of the Tau2024 Global Conference., PMID:40437880

NKG2D triggering hampers DNAM-1-mediated signaling in human NK cells., PMID:40421025

Rationale and feasibility of a rapid integral biomarker program that informs immune-oncology clinical trials: the ADVISE trial., PMID:40389374

Protocol for in-plate staining of clinical peripheral blood mononuclear cell samples for high-throughput analysis via spectral flow cytometry., PMID:40347474

Multiplex immunophenotyping of human acute myeloid leukemia patients revealed single -cell heterogeneity with special attention on therapy sensitive and therapy resistant subpopulations., PMID:40313947

Ophthalmological manifestations and plasma markers of inflammation in Ebola survivors in post-treatment era., PMID:40301432

"Virtual crossmatch reveals donor-specific MICA antibodies in antibody mediated rejection: First established Indian case"., PMID:40280498

CLN-619, a MICA/B monoclonal antibody that promotes innate immune cell-mediated antitumor activity., PMID:40274283

BTK inhibitors enhance NKG2D ligand expression by regulating IL-10/STAT3 pathway in activated non-GCB diffuse large B-cell lymphoma cells., PMID:40029697

Frizzled-7-targeting antibody-derived bifunctional protein retargets NK cells against triple-negative breast cancer cells via MICA-NKG2D axis., PMID:40021214

An epitope-directed mRNA vaccine inhibits tumor metastasis through the blockade of MICA/B α1/2 shedding., PMID:39999840

Clinico-genomic features predict distinct metastatic phenotypes in cutaneous melanoma., PMID:39975034

Detection and Quantification of Polymorphic MICA and MICB Molecules in Immunoassays: Initial Insights., PMID:39902633

NTHi killing activity is reduced in COPD patients and is associated with a differential microbiome., PMID:39885466

Role of the androgen receptor in melanoma aggressiveness., PMID:39837817

Evolution of anti-MICA antibodies after imlifidase infusion for a high immunological risk kidney transplantation., PMID:39826255

Novel and potent MICA/B antibody is therapeutically effective in KRAS LKB1 mutant lung cancer models., PMID:39762078

Cigarette Smoking and Symptom Burden: Baseline Results From Nine ECOG-ACRIN Cancer Clinical Trials., PMID:39746495

Circulating cytokine associations with clinical outcomes in melanoma patients treated with combination nivolumab plus ipilimumab., PMID:39699928

Three-Year Overall Survival With Nivolumab Plus Relatlimab in Advanced Melanoma From RELATIVITY-047., PMID:39671533

[The effect of c-Myc on regulating the immune-related ligands in Y subtype small cell lung cancer through histone deacetylase 1]., PMID:39622733

Long-term outcomes among patients who respond within the first year to nivolumab plus ipilimumab or nivolumab monotherapy: A pooled analysis in 935 patients., PMID:39612757

Sequential Vaccination Against Streptococcus pneumoniae Appears as Immunologically Safe in Clinically Stable Kidney Transplant Recipients., PMID:39591147

MICA and NKG2D gene polymorphisms influence graft survival, and response to therapy in kidney transplantation., PMID:39575256

Stratified analysis identifies HIF-2α as a therapeutic target for highly immune-infiltrated melanomas., PMID:39554029

Targeting RAF1 gene fusions with MEK inhibition in metastatic melanoma., PMID:39504576

Distinct Non-Human Leukocyte Antigen Antibody Signatures Correlate with Endothelial Crossmatch Status in Lung and Renal Transplant Recipients., PMID:39408890

Craters on the melanoma surface facilitate tumor-immune interactions and demonstrate pathologic response to checkpoint blockade in humans., PMID:39345527

Bispecific killer cell engagers employing species cross-reactive NKG2D binders redirect human and murine lymphocytes to ErbB2/HER2-positive malignancies., PMID:39267747

A phase 1 study of the CD40 agonist MEDI5083 in combination with durvalumab in patients with advanced solid tumors., PMID:39264730

A novel and potent MICA/B antibody is therapeutically effective in KRAS LKB1 mutant lung cancer models., PMID:39211152

Nivolumab maintenance improves overall survival of patients with advanced melanoma who experience severe immune-related adverse events on nivolumab plus ipilimumab., PMID:39209453

Immunologic signatures of response and resistance to nivolumab with ipilimumab in advanced metastatic cancer., PMID:39190534

Isolation of anti-tumor monoclonal antibodies targeting on MICA/B α3 domain by single B cell technology for colon cancer therapy., PMID:39170144

Expression and function of the major histocompatibility complex (MHC) class I chain-related A (MICA)*010 in NK cell killing activity., PMID:39116667

Inhibition of MICA and MICB shedding enhances memory-like NK-cell-mediated cytotoxicity against multiple myeloma., PMID:39106432

Myocardial Characteristics, Cardiac Structure, and Cardiac Function in Systemic Light-Chain Amyloidosis., PMID:39001736

Safety, pharmacokinetics, pharmacodynamics, and antitumor activity of SAR439459, a TGFβ inhibitor, as monotherapy and in combination with cemiplimab in patients with advanced solid tumors: Findings from a phase 1/1b study., PMID:38898592

Outcome-based Risk Assessment of Non-HLA Antibodies in Heart Transplantation: A Systematic Review., PMID:38796046

Nanobody-based CAR NK cells for possible immunotherapy of MICA+ tumors., PMID:38756234

Chordoma cancer stem cell subpopulation characterization may guide targeted immunotherapy approaches to reduce disease recurrence., PMID:38741774

Tinostamustine (EDO-S101), an Alkylating Deacetylase Inhibitor, Enhances the Efficacy of Daratumumab in Multiple Myeloma by Upregulation of CD38 and NKG2D Ligands., PMID:38731936

Transmural Flow Upregulates PD-L1 Expression in Microvascular Networks., PMID:38696611

Evasion of NKG2D-mediated cytotoxic immunity by sarbecoviruses., PMID:38653235

Efficacy of Pembrolizumab and Biomarker Analysis in Patients with WGS-Based Intermediate to High Tumor Mutational Load: Results from the Drug Rediscovery Protocol., PMID:38630551

Correction: The impact of ageing on the distribution of preformed anti-HLA and anti-MICA antibody specificities in recipients from eastern China prior to initial HSCT., PMID:38615040

A novel MICA/B-targeted chimeric antigen receptor augments the cytotoxicity of NK cells against tumor cells., PMID:38598902

MICA-specific nanobodies for diagnosis and immunotherapy of MICA+ tumors., PMID:38550583

Synergistic integration of histone deacetylase inhibitors apparently enhances the cytokine-induced killer cell efficiency in multiple myeloma via the NKG2D pathway., PMID:38529413

Datasheet
$ 372
Product specifications
100 μg 372 1 mg 1860

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Anti-Human MICA Antibody (13A9) [RHH45203]
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