Catalog No.
DHE20502
Expression system
Mammalian Cells
Species reactivity
Human
Host species
Human
Isotype
IgG1, kappa
Clonality
Monoclonal
Target
Serine/threonine-protein kinase receptor R3, SKR3, 2.7.11.30, Activin receptor-like kinase 1, ALK-1, TGF-B superfamily receptor type I, TSR-I, ACVRL1, ACVRLK1, ALK1
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
P37023
Applications
Research Grade Biosimilar
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Alternative Names
TATX 21, TATX-21, TATX21
Clone ID
TATX 21
Spitz Spindle Cell/Reed Nevus With SQSTM1 :: NTRK2 Fusion and Atypical Features in an Older Male Patient: A Case Report and Review of Literature., PMID:39980385
Molecular and Functional Cargo of Plasma-Derived Exosomes in Patients with Hereditary Hemorrhagic Telangiectasia., PMID:39336917
Non-Hodgkin's Anaplastic Large T-Cell Lymphoma: A Case Report., PMID:39050306
IL-1β Induces LDL Transcytosis by a Novel Pathway Involving LDLR and Rab27a., PMID:38989581
ALK-positive large B-cell lymphoma (ALK + LBCL) with aberrant CD3 expression., PMID:38573563
Potential Therapeutic Strategies and Drugs That Target Vascular Permeability in Severe Infectious Diseases., PMID:38432910
Negative Hyperselection of Resistance Mutations for Panitumumab Maintenance in RAS Wild-Type Metastatic Colorectal Cancer (PanaMa Phase II Trial, AIO KRK 0212)., PMID:38289994
Induced Endothelial Cell Cycle Arrest Prevents Arteriovenous Malformations in Hereditary Hemorrhagic Telangiectasia., PMID:38126211
Endoglin and squamous cell carcinomas., PMID:37396898
Genetic or therapeutic neutralization of ALK1 reduces LDL transcytosis and atherosclerosis in mice., PMID:39196046
Microcirculation surrounding end-stage human chronic skin wounds is associated with endoglin/CD146/ALK-1 expression, endothelial cell proliferation and an absence of p16Ink4a., PMID:37017097
Immunohistochemistry with 3 different clones in anaplastic lymphoma kinase fluorescence in situ hybridization positive non-small-cell lung cancer with thymidylate synthase expression analysis: a multicentre, retrospective, Italian study., PMID:36083243
Too Sensitive or Just Right?, PMID:35482487
Analyzing the morphological spectrum of epithelioid fibrous histiocytoma and the immunohistochemical performance of the ALK D5F3 and ALK1 clones., PMID:34929229
Strengthening the FDA's Enforcement of ClinicalTrials.gov Reporting Requirements., PMID:34766971
Clinicopathological features and resistance mechanisms in HIP1-ALK-rearranged lung cancer: A multicenter study., PMID:34687488
Sinonasal IgG4-related disease: a rare and emerging entity broadening the differential diagnosis in the sinonasal universe., PMID:33392765
Reduction of endoglin receptor impairs mononuclear cell-migration., PMID:32954380
Review of Pharmacological Strategies with Repurposed Drugs for Hereditary Hemorrhagic Telangiectasia Related Bleeding., PMID:32517280
Transformation of Grade I Follicular Lymphoma to Anaplastic Large Cell Lymphoma CD30+ ALK1- with Complete Response to Brentuximab Vedotin and High-Dose Methotrexate., PMID:32476657
ALK-1-positive inflammatory myofibroblastic tumor of the thyroid complicated by Hashimoto's thyroiditis: report of a rare case and a literature review., PMID:32430041
Incidence of ROS1-Rearranged Non-Small-Cell Lung Carcinoma in India and Efficacy of Crizotinib in Lung Adenocarcinoma Patients., PMID:32158297
Endoglin: Beyond the Endothelium., PMID:32059544
Future treatments for hereditary hemorrhagic telangiectasia., PMID:31910860
A phase Ib study of the combination regorafenib with PF-03446962 in patients with refractory metastatic colorectal cancer (REGAL-1 trial)., PMID:31444620
A phase 2, randomized trial evaluating the combination of dalantercept plus axitinib in patients with advanced clear cell renal cell carcinoma., PMID:30951193
Epidermal growth factor receptor and anaplastic lymphoma kinase mutation in adenocarcinoma lung: Their incidence and correlation with histologic patterns., PMID:30706855
Selective BMP-9 Inhibition Partially Protects Against Experimental Pulmonary Hypertension., PMID:30636542
Detection of Anaplastic Lymphoma Kinase Gene Re-Arrangement in Non-Small Cell Lung Carcinoma in the Indian Population: Comparison of Techniques and Immunohistochemistry Clones., PMID:30596395
Time series analysis of neoadjuvant chemotherapy and bevacizumab-treated breast carcinomas reveals a systemic shift in genomic aberrations., PMID:30497530
A Phase Ib, Open-Label Study of Dalantercept, an Activin Receptor-Like Kinase 1 Ligand Trap, plus Sorafenib in Advanced Hepatocellular Carcinoma., PMID:30352941
Activation of Ras in the Vascular Endothelium Induces Brain Vascular Malformations and Hemorrhagic Stroke., PMID:30208313
Myofibroblastic lesions in the oral cavity: Immunohistochemical and ultrastructural analysis., PMID:30168888
Phase II evaluation of dalantercept in the treatment of persistent or recurrent epithelial ovarian cancer: An NRG Oncology/Gynecologic Oncology Group study., PMID:30041929
SMAD4 Prevents Flow Induced Arteriovenous Malformations by Inhibiting Casein Kinase 2., PMID:29976569
ALK Expression in Angiomatoid Fibrous Histiocytoma: A Potential Diagnostic Pitfall., PMID:29877921
[Inflammatory myofibroblastic tumour of thyroid: a case report]., PMID:29871358
Prognostic Value of ACVRL1 Expression in Metastatic Colorectal Cancer Patients Receiving First-line Chemotherapy With Bevacizumab: Results From the Triplet Plus Bevacizumab (TRIBE) Study., PMID:29636300
Inhibin Is a Novel Paracrine Factor for Tumor Angiogenesis and Metastasis., PMID:29535220
A case report of atypical Spitz tumor harboring a novel MLPH-ALK gene fusion with discordant ALK immunohistochemistry results., PMID:29514107
Impact of selective anti-BMP9 treatment on tumor cells and tumor angiogenesis., PMID:28949445
Transforming growth factor-β stimulates Smad1/5 signaling in pulmonary artery smooth muscle cells and fibroblasts of the newborn mouse through ALK1., PMID:28642261
Clinicopathological Study of 18 Cases of Inflammatory Myofibroblastic Tumors with Reference to ALK-1 Expression: 5-Year Experience in a Tertiary Care Center., PMID:28415158
Selective effects of oral antiangiogenic tyrosine kinase inhibitors on an animal model of hereditary hemorrhagic telangiectasia., PMID:28339142
ALK Gene Copy Number Gain and Immunohistochemical Expression Status Using Three Antibodies in Neuroblastoma., PMID:28326957
Dual targeting of vascular endothelial growth factor and bone morphogenetic protein-9/10 impairs tumor growth through inhibition of angiogenesis., PMID:28133920
The DART Study: Results from the Dose-Escalation and Expansion Cohorts Evaluating the Combination of Dalantercept plus Axitinib in Advanced Renal Cell Carcinoma., PMID:28031424
A mouse model of hereditary hemorrhagic telangiectasia generated by transmammary-delivered immunoblocking of BMP9 and BMP10., PMID:27874028
Custom Gene Capture and Next-Generation Sequencing to Resolve Discordant ALK Status by FISH and IHC in Lung Adenocarcinoma., PMID:27343444
A phase 2 study of dalantercept, an activin receptor-like kinase-1 ligand trap, in patients with recurrent or metastatic squamous cell carcinoma of the head and neck., PMID:27648727
For research use only. Not for human or drug use.
