Catalog No.
EQC09602
Expression system
Mammalian Cells
Species
Canis lupus familiaris (Dog) (Canis familiaris)
Protein length
Thr23-Thr652
Predicted molecular weight
97.29 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
NP_001003217.3
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution.A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
receptor tyrosine-protein kinase erbB-2 precursor, ERBB2
Immunohistochemical Expression of Human Epidermal Growth Factor Receptor 2 and Ki67 in Apocrine Gland Anal Sac Adenocarcinoma., PMID:38928157
Lapatinib antitumor effect is associated with PI3K and MAPK pathway: An analysis in human and canine prostate cancer cells., PMID:38564578
Human basal-like breast cancer is represented by one of the two mammary tumor subtypes in dogs., PMID:37789381
Knockout of all ErbB-family genes delineates their roles in proliferation, survival and migration., PMID:37519219
An Anti-HER2 Monoclonal Antibody H2Mab-41 Exerts Antitumor Activities in Mouse Xenograft Model Using Dog HER2-Overexpressed Cells., PMID:34424760
ErbB2 copy number gain is associated with adverse outcome in canine mammary carcinoma., PMID:33473058
Tucatinib Inhibits Renal Transporters OCT2 and MATE Without Impacting Renal Function in Healthy Subjects., PMID:32989831
Overexpression of human epidermal growth factor receptor 2 in canine primary lung cancer., PMID:32249253
Canine non-B, non-T NK lymphocytes have a potential antibody-dependent cellular cytotoxicity function against antibody-coated tumor cells., PMID:31610784
A novel, safe, fast and efficient treatment for Her2-positive and negative bladder cancer utilizing an EGF-anthrax toxin chimera., PMID:31584195
Detection of human epidermal growth factor receptor 2 overexpression in canine anal sac gland carcinoma., PMID:31142682
Dasatinib inhibition of cSRC prevents the migration and metastasis of canine mammary cancer cells with enhanced Wnt and HER signalling., PMID:31069942
Comparative aspects of canine and human inflammatory breast cancer., PMID:29526258
Gene set enrichment analysis and expression pattern exploration implicate an involvement of neurodevelopmental processes in bipolar disorder., PMID:29197740
Canine invasive mammary carcinomas as models of human breast cancer. Part 1: natural history and prognostic factors., PMID:29086231
Engineered cross-reacting nanobodies simplify comparative oncology between humans and dogs., PMID:29047203
Estrogen receptor-α, progesterone receptor, and c-erbB/HER-family receptor mRNA detection and phenotype analysis in spontaneous canine models of breast cancer., PMID:27515268
Genome-wide association study of 40,000 individuals identifies two novel loci associated with bipolar disorder., PMID:27329760
High basal Wnt signaling is further induced by PI3K/mTor inhibition but sensitive to cSRC inhibition in mammary carcinoma cell lines with HER2/3 overexpression., PMID:26205886
Toward immunotherapy with redirected T cells in a large animal model: ex vivo activation, expansion, and genetic modification of canine T cells., PMID:25198528
EGFR, HER-2 and KRAS in canine gastric epithelial tumors: a potential human model?, PMID:24454858
Regulation of polarized morphogenesis by protein kinase C iota in oncogenic epithelial spheroids., PMID:24072773
[How epithelium gets rid of weird cells]., PMID:23171889
Identification of triple-negative and basal-like canine mammary carcinomas using four basal markers., PMID:23079102
Breed-related differences in altered BRCA1 expression, phenotype and subtype in malignant canine mammary tumors., PMID:22901454
Preclinical assessment of the absorption and disposition of the phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor GDC-0980 and prediction of its pharmacokinetics and efficacy in human., PMID:22696419
Overexpression of her-2/neu in malignant mammary tumors; translation of clinicopathological features from dog to human., PMID:23464468
Identification of genetic variation in 11 candidate genes of canine mammary tumour., PMID:22077404
Canine mammary mixed tumours: immunohistochemical expressions of EGFR and HER-2., PMID:24635633
The metastatic cascade is reflected in the transcriptome of metastatic canine mammary carcinomas., PMID:21112801
Columnar cell lesions of the canine mammary gland: pathological features and immunophenotypic analysis., PMID:20178635
Prevalence and classification of spontaneous mammary intraepithelial lesions in dogs without clinical mammary disease., PMID:20106771
Telomerase and HER-2/neu as targets of genetic cancer vaccines in dogs., PMID:19944791
Discovery and preclinical evaluation of [4-[[1-(3-fluorophenyl)methyl]-1H-indazol-5-ylamino]-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl]carbamic acid, (3S)-3-morpholinylmethyl ester (BMS-599626), a selective and orally efficacious inhibitor of human epidermal growth factor receptor 1 and 2 kinases., PMID:19821562
Identification of molecular phenotypes in canine mammary carcinomas with clinical implications: application of the human classification., PMID:18677512
Increased survival in dogs with malignant mammary tumours overexpressing HER-2 protein and detection of a silent single nucleotide polymorphism in the canine HER-2 gene., PMID:18061495
HGF converts ErbB2/Neu epithelial morphogenesis to cell invasion., PMID:15548598
c-erbB-2 expression and nuclear pleomorphism in canine mammary tumors., PMID:15517084
Overexpression of the erbB-2 proto-oncogene in canine osteosarcoma cell lines and tumors., PMID:15133183
Activation of beta-catenin-TCF-mediated transcription by non-receptor tyrosine kinase v-Src., PMID:14706618
Basolateral targeting of ERBB2 is dependent on a novel bipartite juxtamembrane sorting signal but independent of the C-terminal ERBIN-binding domain., PMID:12192053
Point mutation of neu oncogene in animal peripheral nerve sheath tumors., PMID:11732802
Expression of metastasis-associated mts1 gene is co-induced with membrane type-1 matrix metalloproteinase (MT1-MMP) during oncogenic transformation and tubular formation of Madin Darby canine kidney (MDCK) epithelial cells., PMID:11206838
The tight junction protein ZO-1 and an interacting transcription factor regulate ErbB-2 expression., PMID:10790369
Expression of the oncogene c-erbB-2 in canine mammary cancers and tumor-derived cell lines., PMID:8723884
p53, erbB-2 and K-ras gene alterations are rare in spontaneous and plutonium-239-induced canine lung neoplasia., PMID:8606928
For research use only. Not for human or drug use.
