Catalog No.
PHJ48001
Species reactivity
Human, Mouse, Rat
Host species
Rabbit
Isotype
IgG
Clonality
Polyclonal
Immunogen
E. coli - derived recombinant Human MYOC (Ala224-Tyr471).
Tested applications
ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000
Target
MYOC,Myocilin,Trabecular meshwork-induced glucocorticoid response protein,GLC1A,TIGR,Myocilin 55 kDa subunit,Myocilin 35 kDa N-terminal fragment,Myocilin 20 kDa N-terminal fragment
Purification
Purified by antigen affinity column.
Accession
Q99972
Applications
ELISA, IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
A proteomic approach towards understanding the pathogenesis of Mooren's ulcer., PMID:33647271
Histochemical Analysis of Glaucoma Caused by a Myocilin Mutation in a Human Donor Eye., PMID:30906929
Molecular Details of Olfactomedin Domains Provide Pathway to Structure-Function Studies., PMID:26121352
Complex genetic mechanisms in glaucoma: an overview., PMID:21150032
Efficient in vivo doxycycline and cre recombinase-mediated inducible transgene activation in the murine trabecular meshwork., PMID:21051732
Transgenic mice expressing the Tyr437His mutant of human myocilin protein develop glaucoma., PMID:18436825
Aqueous humor myocilin protein levels in normal, genetic carriers, and glaucoma Beagles., PMID:18435660
Immunohistochemical evaluation of the extracellular matrix in trabecular meshwork in steroid-induced glaucoma., PMID:18386038
Immunolocalization of myocilin protein in the anterior eye of normal and primary open-angle glaucomatous dogs., PMID:17973832
[Comparative study of eukaryotic cell expression of wild-type and Pro370Leu mutation type myocilin gene]., PMID:16681932
Regulation of glucocorticoid responsiveness in glaucomatous trabecular meshwork cells by glucocorticoid receptor-beta., PMID:16303956
Protein expression, genomic structure, and polymorphisms of oculomedin., PMID:12868032
In vitro localization of TIGR/MYOC in trabecular meshwork extracellular matrix and binding to fibronectin., PMID:11773026
Glucocorticoid induction of the glaucoma gene MYOC in human and monkey trabecular meshwork cells and tissues., PMID:11431441
Expression of the glaucoma gene myocilin (MYOC) in the human optic nerve head., PMID:11344104
Immunohistochemical localization of MYOC/TIGR protein in the trabecular tissue of normal and glaucomatous eyes., PMID:11262617
Recombinant TIGR/MYOC increases outflow resistance in the human anterior segment., PMID:11095610
Expression of the TIGR gene in the iris, ciliary body, and trabecular meshwork of the human eye., PMID:11035548
Regulation of human myocilin/TIGR gene transcription in trabecular meshwork cells and astrocytes: role of upstream stimulatory factor., PMID:10947851
Isolation, culture, and characterization of endothelial cells from Schlemm's canal., PMID:9727403
Localization of Dictyostelium myoB and myoD to filopodia and cell-cell contact sites using isoform-specific antibodies., PMID:8980908
Dictyostelium mutants lacking multiple classic myosin I isoforms reveal combinations of shared and distinct functions., PMID:8609164