Catalog No.
DHK27202
Expression system
Mammalian Cells
Species reactivity
Human
Host species
Human
Isotype
IgG1-kappa
Clonality
Monoclonal
Target
Cytokine receptor-like factor 2, Cytokine receptor-like 2, IL-XR, Thymic stromal lymphopoietin protein receptor, TSLP receptor, CRLF2, CRL2, ILXR, TSLPR
Concentration
3.25 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
Q9HC73
Applications
Research Grade Biosimilar
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Alternative Names
RG-7258, RG7258, RG 7258
Clone ID
RG-7258
Distinct roles for thymic stromal lymphopoietin (TSLP) and IL-33 in experimental eosinophilic esophagitis., PMID:40060399
Triclosan exacerbates atopic dermatitis in mouse models via thymic stromal lymphopoietin., PMID:40059030
Targeting alarmins in asthma: From bench to clinic., PMID:39855362
TSLP acts on regulatory T cells to maintain their identity and limit allergic inflammation., PMID:39792638
Thymic stromal lymphopoietin modulates T cell response and improves cardiac repair post-myocardial infarction., PMID:39703503
Elevated circulating group-2 innate lymphoid cells expressing activation markers and correlated tryptase AB1 levels in active ascariasis., PMID:39524451
Bleomycin triggers chronic mechanical nociception by activating TRPV1 and glial reaction-mediated neuroinflammation via TSLP/TSLPR/pSTAT5 signals., PMID:39277019
Thymic Stromal Lymphopoietin and Tezepelumab in Airway Diseases: From Physiological Role to Target Therapy., PMID:38892164
Development of a novel humanized anti-TSLP monoclonal antibody HZ-1127 with anti-allergic diseases and cancer potential., PMID:38566968
Correction: Preclinical development of 1B7/CD3, a novel anti-TSLPR bispecific antibody that targets CRLF2-rearranged Ph-like B-ALL., PMID:38036631
EFFECT OF ANTI-TSLPR MONOCLONAL ANTIBODY ON VIABILITY, PROAPOPTOTIC GENES EXPRESSION, AND PRODUCTION OF PRO-INFLAMMATORY CYTOKINES IN MCF-7 AND A549 CELLS., PMID:37824770
Preclinical development of 1B7/CD3, a novel anti-TSLPR bispecific antibody that targets CRLF2-rearranged Ph-like B-ALL., PMID:37634013
TSLP/TSLPR promotes renal fibrosis by activating STAT3 in renal fibroblasts., PMID:37364323
Severe asthma ILC2s demonstrate enhanced proliferation that is modified by biologics., PMID:37114915
B cell- and T cell-intrinsic regulation of germinal centers by thymic stromal lymphopoietin signaling., PMID:36608149
The Impact of Tezepelumab in Uncontrolled Severe Asthma: A Systematic Review of Randomized Controlled Trials., PMID:36601189
Nonylphenol exacerbates ovalbumin-induced allergic rhinitis via the TSLP-TSLPR/IL-7R pathway and JAK1/2-STAT3 signaling in a mouse model., PMID:36029577
Emerging role for thymic stromal lymphopoietin-responsive regulatory T cells in colorectal cancer progression in humans and mice., PMID:35584230
Type 2 immunity plays an essential role for murine model of allergic contact dermatitis with mixed type 1/type 2 immune response., PMID:34763990
ASP7266, a Novel Antibody against Human Thymic Stromal Lymphopoietin Receptor for the Treatment of Allergic Diseases., PMID:34728559
Interferon-λ Improves the Efficacy of Intranasally or Rectally Administered Influenza Subunit Vaccines by a Thymic Stromal Lymphopoietin-Dependent Mechanism., PMID:34659250
Thymic stromal lymphopoietin induces adipose loss through sebum hypersecretion., PMID:34326208
Thymic stromal lymphopoietin contributes to protection of mice from Strongyloides venezuelensis infection by CD4+ T cell-dependent and -independent pathways., PMID:33819747
TSLP-Driven Chromatin Remodeling and Trained Systemic Immunity after Neonatal Respiratory Viral Infection., PMID:33514510
Aspergillus fumigatus-Stimulated Human Corneal Epithelial Cells Induce Pyroptosis of THP-1 Macrophages by Secreting TSLP., PMID:33118609
Critical Role of TSLP Receptor on CD4 T Cells for Exacerbation of Skin Inflammation., PMID:32444388
Thymic stromal lymphopoietin is a key cytokine for the immunomodulation of atherogenesis with Freund's adjuvant., PMID:32285594
Thymic stromal lymphopoietin protects in a model of airway damage and inflammation via regulation of caspase-1 activity and apoptosis inhibition., PMID:32103153
TSLP Inhibitors for Asthma: Current Status and Future Prospects., PMID:32078149
Targeted deletion of the TSLP receptor reveals cellular mechanisms that promote type 2 airway inflammation., PMID:32066836
Repurposing the psoriasis drug Oxarol to an ointment adjuvant for the influenza vaccine., PMID:32060507
Anti-TSLP antibodies: Targeting a master regulator of type 2 immune responses., PMID:31974038
Yu Ping Feng San Exert Anti-Angiogenesis Effects through the Inhibition of TSLP-STAT3 Signaling Pathways in Hepatocellular Carcinoma., PMID:31885639
TSLP protects against liver I/R injury via activation of the PI3K/Akt pathway., PMID:31723054
TSLP contributes to allergic airway inflammation induced by diesel exhaust particle exposure in an experimental model of severe asthma., PMID:31610053
Tumor-Derived Thymic Stromal Lymphopoietin Expands Bone Marrow B-cell Precursors in Circulation to Support Metastasis., PMID:31575547
Tezepelumab: a novel biological therapy for the treatment of severe uncontrolled asthma., PMID:31549891
Type I and Type III Interferons Differ in Their Adjuvant Activities for Influenza Vaccines., PMID:31511392
Short ragweed pollen promotes M2 macrophage polarization via TSLP/TSLPR/OX40L signaling in allergic inflammation., PMID:31350466
Prostaglandin E2 (PGE2)-EP2 signaling negatively regulates murine atopic dermatitis-like skin inflammation by suppressing thymic stromal lymphopoietin expression., PMID:31301371
Sex-associated TSLP-induced immune alterations following early-life RSV infection leads to enhanced allergic disease., PMID:31076663
Viral vector and route of administration determine the ILC and DC profiles responsible for downstream vaccine-specific immune outcomes., PMID:30733092
TSLP Protects Corneas From Pseudomonas aeruginosa Infection by Regulating Dendritic Cells and IL-23-IL-17 Pathway., PMID:30128494
A versatile platform for activity determination of cytokines and growth factors based on the human TSLP (thymic stromal lymphopoietin) receptor., PMID:30033138
CD1a-Expressing Monocytes as Mediators of Inflammation in Ulcerative Colitis., PMID:29788291
TSLP-activated dendritic cells induce T helper type 2 inflammation in Aspergillus fumigatus keratitis., PMID:29550278
Detection of Minimal Bone Marrow involvement of Blastic Plasmacytoid Dendritic Cell Neoplastic Cells - CD303 immunostaining as a diagnostic tool., PMID:29415975
TSLP promotes angiogenesis of human umbilical vein endothelial cells by strengthening the crosstalk between cervical cancer cells and eosinophils., PMID:29344192
Human thymic stromal lymphopoietin promotes the proliferation and invasion of cervical cancer cells by downregulating microRNA-132 expression., PMID:29250181
Role of the TSLP-DC-OX40L pathway in asthma pathogenesis and airway inflammation in mice., PMID:29024606
For research use only. Not for human or drug use.
