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Anti-Human CFTR Polyclonal Antibody

Catalog #:   PHC98301 Specific References (50) DATASHEET
Host species: Rabbit
Isotype: IgG
Applications: ELISA, IHC, WB
Accession: P13569
Overview

Catalog No.

PHC98301

Species reactivity

Human

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human CFTR (Ile1203-Ser1426).

Tested applications

ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000

Target

Cystic fibrosis transmembrane conductance regulator, CFTR, ATP-binding cassette sub-family C member 7, Channel conductance-controlling ATPase, 5.6.1.6, cAMP-dependent chloride channel, CFTR, ABCC7

Purification

Purified by antigen affinity column.

Accession

P13569

Applications

ELISA, IHC, WB

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Data Image
  • Western Blot
    Recombinant Protein lysates were subjected to SDS PAGE followed by western blot with CFTR antibody (PHC98301) at 1 µg/ml.

    Lane 1: Recombinant Protein

    Second Ab: Goat Anti-Rabbit IgG H&L Polyclonal antibody, HRP (PTB96431) at 0.1 μg/mL.

    Predict MW: 26 kDa
    Observed MW: 26 kDa
References

A Cftr-independent, Ano1-rich seawater-adaptive ionocyte in sea lamprey gills., PMID:40007443

Respiratory Outcomes and Aspergillus Serology Following Elexacaftor/Tezacaftor/Ivacaftor Therapy in People with Cystic Fibrosis and a History of Aspergillus fumigatus Infection., PMID:39762638

Changes in immunofluorescence staining during islet regeneration in a cystic fibrosis-related diabetes (CFRD) ferret model., PMID:39641365

Recurrent eosinophilia with a novel homozygous ARPC1B mutation., PMID:39609360

Inhalation of SP-101 Followed by Inhaled Doxorubicin Results in Robust and Durable hCFTRΔR Transgene Expression in the Airways of Wild-Type and Cystic Fibrosis Ferrets., PMID:39155828

Evaluation of anti-vector immune responses to adenovirus-mediated lung gene therapy and modulation by αCD20., PMID:39070292

Analysis of CFTR mRNA and Protein in Peripheral Blood Mononuclear Cells via Quantitative Real-Time PCR and Western Blot., PMID:38928073

Allergic bronchopulmonary aspergillosis in a lung transplant recipient treated with mepolizumab., PMID:38801928

Durable transgene expression and efficient re-administration after rAAV2.5T-mediated fCFTRΔR gene delivery to adult ferret lungs., PMID:38638546

Therapeutic Targets and Precision Medicine in COPD: Inflammation, Ion Channels, Both, or Neither?, PMID:38139192

Systems serology in cystic fibrosis: Anti-Pseudomonas IgG1 responses and reduced lung function., PMID:37852181

CFTR potentiator ivacaftor protects against noise-induced hair cell loss by increasing Nrf2 and reducing oxidative stress., PMID:37657258

Discovery of a Hidden Proinflammatory Signaling Proteome Using a Large-Scale, Targeted Antibody Microarray Platform., PMID:37191800

Elexacaftor - Tezacaftor - Ivacaftor treatment improves systemic infection parameters and Pseudomonas aeruginosa colonization rate in patients with cystic fibrosis a monocentric observational study., PMID:37153441

Immunosuppression reduces rAAV2.5T neutralizing antibodies that limit efficacy following repeat dosing to ferret lungs., PMID:36950451

Histological and immunohistochemical outcomes after microdissection TESE in contrast with hormonal profile, testis volume and genetics in patients with azoospermia., PMID:36873127

Molecular targets for cystic fibrosis and therapeutic potential of monoclonal antibodies., PMID:36601503

Expression of CFTR, a hallmark gene of ionocytes, is downregulated in salivary glands of Sjögren's syndrome patients., PMID:36476557

Culture independent markers of nontuberculous mycobacterial (NTM) lung infection and disease in the cystic fibrosis airway., PMID:36417800

Insulin-Like Growth Factor Binding Protein (IGFBP-6) as a Novel Regulator of Inflammatory Response in Cystic Fibrosis Airway Cells., PMID:35903151

The first report on the association of celiac disease and cystic fibrosis in a tertiary care center in Saudi Arabia., PMID:35573074

Host and pathogen response to bacteriophage engineered against Mycobacterium abscessus lung infection., PMID:35568033

The clinical impact of the Covid-19 pandemic first wave on patients with cystic fibrosis in New York., PMID:35256307

Serum anti-PAD4 autoantibodies are present in cystic fibrosis children and increase with age and lung disease severity., PMID:35199621

Identification and selection of healthy spermatozoa in heterozygous carriers of the Phe508del-variant of the CFTR-gene in assisted reproduction., PMID:35115637

Treatment of cystic fibrosis related bone disease., PMID:35059303

Immunoglobulin A Mucosal Immunity and Altered Respiratory Epithelium in Cystic Fibrosis., PMID:34944110

Nonspecific binding of common anti-CFTR antibodies in ciliated cells of human airway epithelium., PMID:34853321

Short-Term Steroid Treatment of Rhesus Macaque Increases Transduction., PMID:34806411

Generation of functional ciliated cholangiocytes from human pluripotent stem cells., PMID:34764255

Association of the CFTR gene with asthma and airway mucus hypersecretion., PMID:34086689

Effect of Alpha-1 Antitrypsin on CFTR Levels in Primary Human Airway Epithelial Cells Grown at the Air-Liquid-Interface., PMID:33946490

Co-Translational Folding of the First Transmembrane Domain of ABC-Transporter CFTR is Supported by Assembly with the First Cytosolic Domain., PMID:33771570

Does cystic fibrosis make susceptible to celiac disease?, PMID:33765186

VJ Segment Usage of TCR-Beta Repertoire in Monozygotic Cystic Fibrosis Twins., PMID:33708199

Mepolizumab use in cystic fibrosis-associated allergic bronchopulmonary aspergillosis., PMID:33304594

Heterogeneous expression of CFTR in insulin-secreting β-cells of the normal human islet., PMID:33264332

Repeat Dosing of AAV2.5T to Ferret Lungs Elicits an Antibody Response That Diminishes Transduction in an Age-Dependent Manner., PMID:33209961

Cell-based non-invasive prenatal diagnosis in a pregnancy at risk of cystic fibrosis., PMID:33150588

Mucosal humoral immunity in cystic fibrosis - a tangled web of failed proteostasis, infection and adaptive immunity., PMID:32971469

Lung immunoglobulin A immunity dysregulation in cystic fibrosis., PMID:32927272

Pathways in the Pathophysiology of Coronavirus 19 Lung Disease Accessible to Prevention and Treatment., PMID:32922301

Organoids as a personalized medicine tool for ultra-rare mutations in cystic fibrosis: The case of S955P and 1717-2A>G., PMID:32730979

DLL4 restores damaged liver by enhancing hBMSC differentiation into cholangiocytes., PMID:32622343

Dysregulation of intestinal epithelial CFTR-dependent Cl- ion transport and paracellular barrier function drives gastrointestinal symptoms of food-induced anaphylaxis in mice., PMID:32576925

Glucocorticoids and serum- and glucocorticoid-inducible kinase 1 are potent regulators of CFTR in the native intestine: implications for stress-induced diarrhea., PMID:32567324

Overcoming Immunological Challenges to Helper-Dependent Adenoviral Vector-Mediated Long-Term CFTR Expression in Mouse Airways., PMID:32443586

Improved Fmoc-solid-phase peptide synthesis of an extracellular loop of CFTR for antibody selection by the phage display technology., PMID:32400108

Salinity-dependent expression of ncc2 in opercular epithelium and gill of mummichog (Fundulus heteroclitus)., PMID:31980891

High-resolution imaging of the actin cytoskeleton and epithelial sodium channel, CFTR, and aquaporin-9 localization in the vas deferens., PMID:31950584

Datasheet
$ 170
Product specifications
50 μg 170 100 μg 280

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For research use only. Not for human or drug use.

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Anti-Human CFTR Polyclonal Antibody [PHC98301]
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