Catalog No.
PHJ45501
Species reactivity
Human
Host species
Rabbit
Isotype
IgG
Clonality
Polyclonal
Immunogen
E. coli - derived recombinant Human OSMR (Glu28-Glu342).
Tested applications
ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000
Target
OSMRB,IL-31R subunit beta,Oncostatin-M-specific receptor subunit beta,Interleukin-31 receptor subunit beta,IL-31RB,IL-31R-beta,OSMR,IL-31 receptor subunit beta
Purification
Purified by antigen affinity column.
Accession
Q99650
Applications
ELISA, IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Blocking Oncostatin M receptor abrogates STAT3 mediated integrin signaling and overcomes chemoresistance in ovarian cancer., PMID:38839865
Engineered interleukin-6-derived cytokines recruit artificial receptor complexes and disclose CNTF signaling via the OSMR., PMID:38569939
Nonspecific Inhibition of IL6 Family Cytokine Signalling by Soluble gp130., PMID:38338642
M1 macrophage-derived oncostatin M induces osteogenic differentiation of ligamentum flavum cells through the JAK2/STAT3 pathway., PMID:38222812
Oncostatin M: Dual Regulator of the Skeletal and Hematopoietic Systems., PMID:38198032
Circulating neutrophils activated by cancer cells and M2 macrophages promote gastric cancer progression during PD-1 antibody-based immunotherapy., PMID:37333017
Mirikizumab Regulates Genes Involved in Ulcerative Colitis Disease Activity and Anti-TNF Resistance: Results From a Phase 2 Study., PMID:36881820
Nanoimmunosensor for the electrochemical detection of oncostatin M receptor and monoclonal autoantibodies in systemic sclerosis., PMID:36706502
Oncostatin M Receptor as a Therapeutic Target for Radioimmune Therapy in Synovial Sarcoma., PMID:35745569
Mucosal IL23A expression predicts the response to Ustekinumab in inflammatory bowel disease., PMID:34448069
Oncostatin M Receptor-Targeted Antibodies Suppress STAT3 Signaling and Inhibit Ovarian Cancer Growth., PMID:34380633
OSMR controls glioma stem cell respiration and confers resistance of glioblastoma to ionizing radiation., PMID:32807793
Feline Interleukin-31 Shares Overlapping Epitopes with the Oncostatin M Receptor and IL-31RA., PMID:32459958
Transcriptomic Analysis of Spleen Revealed Mechanism of Dexamethasone-Induced Immune Suppression in Chicks., PMID:32384708
Oncostatin M reduces atherosclerosis development in APOE*3Leiden.CETP mice and is associated with increased survival probability in humans., PMID:31461490
Pathophysiologic mechanisms of itch in bullous pemphigoid., PMID:31351883
Skin Gene Expression Is Prognostic for the Trajectory of Skin Disease in Patients With Diffuse Cutaneous Systemic Sclerosis., PMID:29858547
Anti-oncostatin M antibody inhibits the pro-malignant effects of oncostatin M receptor overexpression in squamous cell carcinoma., PMID:29205362
Oncostatin M drives intestinal inflammation and predicts response to tumor necrosis factor-neutralizing therapy in patients with inflammatory bowel disease., PMID:28368383
Human basophils are a source of - and are differentially activated by - IL-31., PMID:28000952
RET mutation p.S891A in a Chinese family with familial medullary thyroid carcinoma and associated cutaneous amyloidosis binding OSMR variant p.G513D., PMID:26356818
Oncostatin-M differentially regulates mesenchymal and proneural signature genes in gliomas via STAT3 signaling., PMID:25748242
A genome-wide association study for clinical mastitis in first parity US Holstein cows using single-step approach and genomic matrix re-weighting procedure., PMID:25658712
Analysis of IL-6/gp130 family receptor expression reveals that in contrast to astroglia, microglia lack the oncostatin M receptor and functional responses to oncostatin M., PMID:25103368
Oncostatin M receptor is a novel therapeutic target in cervical squamous cell carcinoma., PMID:24659184
Characterization of the CD40L/Oncostatin M/Oncostatin M receptor axis as an antiviral and immunostimulatory system disrupted in chronic HCV infection., PMID:24418171
Association of OSMR gene polymorphisms with rheumatoid arthritis and systemic lupus erythematosus patients., PMID:24219225
Tissue transglutaminase mediates the pro-malignant effects of oncostatin M receptor over-expression in cervical squamous cell carcinoma., PMID:23765377
Induction of osteogenesis in mesenchymal stem cells by activated monocytes/macrophages depends on oncostatin M signaling., PMID:22267310
Overexpression of the oncostatin M receptor in cervical squamous cell carcinoma cells is associated with a pro-angiogenic phenotype and increased cell motility and invasiveness., PMID:21952923
A receptor fusion protein for the inhibition of murine oncostatin M., PMID:21223559
Early differential expression of oncostatin M in obstructive nephropathy., PMID:20626292
Oncostatin M pathway plays a major role in the renal acute phase response., PMID:19158344
Tocilizumab inhibits signal transduction mediated by both mIL-6R and sIL-6R, but not by the receptors of other members of IL-6 cytokine family., PMID:16102523
Essential function of oncostatin m in nociceptive neurons of dorsal root ganglia., PMID:14985435
Oncostatin M regulation of interleukin-6 expression in astrocytes: biphasic regulation involving the mitogen-activated protein kinases ERK1/2 and p38., PMID:10899931
For research use only. Not for human or drug use.
