Anti-P2RX7 Polyclonal Antibody

Catalog No.

PHJ44801

Species reactivity

Human, Mouse, Rat

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human P2RX7 (Asp356-Tyr595).

Tested applications

ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000

Target

P2RX7,Purinergic receptor,P2X purinoceptor 7,P2X7,P2Z receptor,ATP receptor

Concentration

1.73 mg/ml

Purification

Purified by antigen affinity column.

Accession

Q99572

Applications

ELISA, IHC, WB

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

CRISP3-PSP94 complex regulates P2RX7 mediated signalling in prostate cancer cells and macrophages via CITED2., PMID:40473221

Impaired LPS Signaling in Macrophages Overexpressing the P2X7 C-Terminal Domain or Anti-P2X7 C-Terminal Domain Intrabody., PMID:39940947

The Anti-Human P2X7 Monoclonal Antibody (Clone L4) Can Mediate Complement-Dependent Cytotoxicity of Human Leukocytes., PMID:39853757

ATP-P2X7R pathway activation limits the Tfh cell compartment during pediatric RSV infection., PMID:39044830

Increased concentrations of P2X7R in oligodendrocyte derived extracellular vesicles of Multiple sclerosis patients., PMID:38996986

The P2X7 Receptor is a Master Regulator of Microparticle and Mitochondria Exchange in Mouse Microglia., PMID:38984997

Oxidized ATP Suppresses B Lymphocyte Activity to Attenuate Antibody-mediated Rejection of Kidney Allografts in Mice., PMID:38946027

The purinergic receptor P2X7 as a modulator of viral vector-mediated antigen cross-presentation., PMID:38711513

Preconditioning-Induced Facilitation of Lactate Release from Astrocytes Is Essential for Brain Ischemic Tolerance., PMID:38604775

Disruption of the Na+/K+-ATPase-purinergic P2X7 receptor complex in microglia promotes stress-induced anxiety., PMID:38395698

A Species-Specific Anti-Human P2X7 Monoclonal Antibody Reduces Graft-versus-Host Disease in Humanised Mice., PMID:37765233

Soybean lectin-triggered IL-6 secretion induces autophagy to kill intracellular mycobacteria through P2RX7 dependent activation of the JAK2/STAT3/Mcl-1 pathway., PMID:37716189

Animal Models for the Investigation of P2X7 Receptors., PMID:37175933

Macrophages and glia are the dominant P2X7-expressing cell types in the gut nervous system-No evidence for the role of neuronal P2X7 receptors in colitis., PMID:36634819

Origin, distribution, and function of three frequent coding polymorphisms in the gene for the human P2X7 ion channel., PMID:36467077

NLRP3 Inflammasome Activation Through Heart-Brain Interaction Initiates Cardiac Inflammation and Hypertrophy During Pressure Overload., PMID:36440584

Inflammasome Activity in Response to Influenza Vaccination Is Maintained in Monocyte-Derived Peripheral Blood Macrophages in Older Adults., PMID:35822051

Preparation of the Murine Anti-Human P2X7 Receptor Monoclonal Antibody (Clone L4)., PMID:35776321

Maternal P2X7 receptor inhibition prevents autism-like phenotype in male mouse offspring through the NLRP3-IL-1β pathway., PMID:35065198

Identification of Follicular T Cells in the Gut., PMID:34802124

The P2X7 purinergic receptor in intervertebral disc degeneration., PMID:34668208

A Methodological Approach Using rAAV Vectors Encoding Nanobody-Based Biologics to Evaluate ARTC2.2 and P2X7 In Vivo., PMID:34489954

The P2X7 Receptor: A Promising Pharmacological Target in Diabetic Retinopathy., PMID:34281162

Confocal Blood Flow Videomicroscopy of Thrombus Formation over Human Arteries and Local Targeting of P2X7., PMID:33920051

Immunohistochemical evidence of P2X7R, P2X4R and CaMKK2 in pyramidal neurons of frontal cortex does not align with Alzheimer's disease., PMID:33838119

A P2rx7 Passenger Mutation Affects the Vitality and Function of T cells in Congenic Mice., PMID:33336163

Purinergic Signaling in Pancreas-From Physiology to Therapeutic Strategies in Pancreatic Cancer., PMID:33233631

Inhibition of purinergic P2X receptor 7 (P2X7R) decreases granulocyte-macrophage colony-stimulating factor (GM-CSF) expression in U251 glioblastoma cells., PMID:32908225

Long-lived T follicular helper cells retain plasticity and help sustain humoral immunity., PMID:32144185

Blockade of the Phagocytic Receptor MerTK on Tumor-Associated Macrophages Enhances P2X7R-Dependent STING Activation by Tumor-Derived cGAMP., PMID:32049051

Production, characterization, and application of a monoclonal antibody specific for the extracellular domain of human P2X7R., PMID:31930453

Targeting CD39 in Cancer Reveals an Extracellular ATP- and Inflammasome-Driven Tumor Immunity., PMID:31699796

Role of the P2X7 receptor in in vitro and in vivo glioma tumor growth., PMID:31448051

Activation of P2X7R- NLRP3 pathway in Retinal microglia contribute to Retinal Ganglion Cells death in chronic ocular hypertension (COH)., PMID:31445901

Enrichment of intestinal Lactobacillus by enhanced secretory IgA coating alters glucose homeostasis in P2rx7-/- mice., PMID:31249344

MiR-187-3p mimic alleviates ischemia-reperfusion-induced pain hypersensitivity through inhibiting spinal P2X7R and subsequent mature IL-1β release in mice., PMID:31100367

Attenuating Diabetic Vascular and Neuronal Defects by Targeting P2rx7., PMID:31035433

Amyloid β-dependent mitochondrial toxicity in mouse microglia requires P2X7 receptor expression and is prevented by nimodipine., PMID:31019207

P2X7-mediated ATP secretion is accompanied by depletion of cytosolic ATP., PMID:31016551

P2RX7 Deletion in T Cells Promotes Autoimmune Arthritis by Unleashing the Tfh Cell Response., PMID:30949163

P2X7 receptor restrains pathogenic Tfh cell generation in systemic lupus erythematosus., PMID:30655308

ATP in the tumour microenvironment drives expression of nfP2X7, a key mediator of cancer cell survival., PMID:30087439

P2X7 receptor mediates NLRP3-dependent IL-1β secretion and parasite proliferation in Toxoplasma gondii-infected human small intestinal epithelial cells., PMID:29291748

Neuronal P2X7 Receptors Revisited: Do They Really Exist?, PMID:28747388

T Follicular Helper Cells Promote a Beneficial Gut Ecosystem for Host Metabolic Homeostasis by Sensing Microbiota-Derived Extracellular ATP., PMID:28297661

A phase I clinical trial demonstrates that nfP2X7 -targeted antibodies provide a novel, safe and tolerable topical therapy for basal cell carcinoma., PMID:28150889

Nanobodies that block gating of the P2X7 ion channel ameliorate inflammation., PMID:27881823

P2X7 nucleotide receptor signaling potentiates the Wnt/β-catenin pathway in cells of the osteoblast lineage., PMID:27206526

Single Nucleotide Polymorphisms in P2X7 Gene Are Associated with Serum Immunoglobulin G Responses to Mycobacterium tuberculosis in Tuberculosis Patients., PMID:26798189

Nucleoside Reverse Transcriptase Inhibitors Suppress Laser-Induced Choroidal Neovascularization in Mice., PMID:26529046

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