Anti-NEU1/Sialidase-1 Polyclonal Antibody

Catalog No.

PHJ44101

Species reactivity

Human, Mouse, Rat

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human NEU1/Sialidase-1 (Ala110-Pro262).

Tested applications

ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000

Target

Sialidase-1,G9 sialidase,NEU1,N-acetyl-alpha-neuraminidase 1,NANH,Acetylneuraminyl hydrolase,Lysosomal sialidase

Purification

Purified by antigen affinity column.

Accession

Q99519

Applications

ELISA, IHC, WB

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Targeting Aberrantly Elevated Sialyl Lewis A as a Potential Therapy for Impaired Endometrial Selection Ability in Unexplained Recurrent Miscarriage., PMID:35837404

Antiplatelet antibody predicts platelet desialylation and apoptosis in immune thrombocytopenia., PMID:35199503

Critical Involvement of CD44 in T Helper Type 2 Cell-Mediated Eosinophilic Airway Inflammation in a Mouse Model of Acute Asthma., PMID:35069598

Platelet desialylation and TFH cells-the novel pathway of immune thrombocytopenia., PMID:33722280

[Enzyme activity of neuraminidase 1 correlated with the biological behavior of prostate cancer PC3 and DU145 cell lines]., PMID:33377727

The role of neuraminidase in TLR4-MAPK signalling and the release of cytokines by lupus serum-stimulated mesangial cells., PMID:33314123

Lipopolysaccharide activates microglia via neuraminidase 1 desialylation of Toll-like Receptor 4., PMID:32279315

Hydroxychloroquine enhances the antitumor effects of BC001 in gastric cancer., PMID:31268153

Immunoglobulin Binding Protein 1 as a Potential Urine Biomarker in Patients with Lupus Nephritis., PMID:31137925

α-2,3-Sialyltransferase 1 and neuraminidase-3 from monocytes in patients with rheumatoid arthritis correlate with disease activity measures: A pilot study., PMID:30913115

Simultaneous induction of distinct protein phase separation events in multiple subcellular compartments of a single cell., PMID:30851242

Neu-medullocytes, sialidase-positive B cells in the thymus, express autoimmune regulator (AIRE)., PMID:30696872

[Research Progress of Desialylation in Immune Thrombocytopenia -Review]., PMID:29950245

Neuraminidase activity mediates IL-6 production by activated lupus-prone mesangial cells., PMID:29357434

Antibody against Microbial Neuraminidases Recognizes Human Sialidase 3 (NEU3): the Neuraminidase/Sialidase Superfamily Revisited., PMID:28655817

Sialyltransferase and Neuraminidase Levels/Ratios and Sialic Acid Levels in Peripheral Blood B Cells Correlate with Measures of Disease Activity in Patients with Systemic Lupus Erythematosus and Rheumatoid Arthritis: A Pilot Study., PMID:26981635

Oseltamivir-conjugated polymeric micelles prepared by RAFT living radical polymerization as a new active tumor targeting drug delivery platform., PMID:26788555

Rapid Trimming of Cell Surface Polysialic Acid (PolySia) by Exovesicular Sialidase Triggers Release of Preexisting Surface Neurotrophin., PMID:25750127

Oseltamivir phosphate monotherapy ablates tumor neovascularization, growth, and metastasis in mouse model of human triple-negative breast adenocarcinoma., PMID:25525387

Transcriptional factor snail controls tumor neovascularization, growth and metastasis in mouse model of human ovarian carcinoma., PMID:26932374

A novel insulin receptor-signaling platform and its link to insulin resistance and type 2 diabetes., PMID:24583283

A novel epidermal growth factor receptor-signaling platform and its targeted translation in pancreatic cancer., PMID:23993964

G-protein coupled receptor agonists mediate Neu1 sialidase and matrix metalloproteinase-9 cross-talk to induce transactivation of TOLL-like receptors and cellular signaling., PMID:22759791

CD44 is critical for airway accumulation of antigen-specific Th2, but not Th1, cells induced by antigen challenge in mice., PMID:21874648

Elastin peptides signaling relies on neuraminidase-1-dependent lactosylceramide generation., PMID:21103358

Thymoquinone from nutraceutical black cumin oil activates Neu4 sialidase in live macrophage, dendritic, and normal and type I sialidosis human fibroblast cells via GPCR Galphai proteins and matrix metalloproteinase-9., PMID:20213245

Sialidase occurs in both membranes of the nuclear envelope and hydrolyzes endogenous GD1a., PMID:19686243

Contribution of sialidase NEU1 to suppression of metastasis of human colon cancer cells through desialylation of integrin beta4., PMID:19151752

Neuraminidase-1, a subunit of the cell surface elastin receptor, desialylates and functionally inactivates adjacent receptors interacting with the mitogenic growth factors PDGF-BB and IGF-2., PMID:18772331

Low expression of Neu2 sialidase in the thymus of SM/J mice-existence of neuraminidase positive cells "Neu-medullocyte" in the murine thymus., PMID:18553168

Enhanced expression of membrane-associated sialidase Neu3 decreases GD3 and increases GM3 on the surface of Jurkat cells during etoposide-induced apoptosis., PMID:17827720

Monocyte differentiation up-regulates the expression of the lysosomal sialidase, Neu1, and triggers its targeting to the plasma membrane via major histocompatibility complex class II-positive compartments., PMID:16835219

Elastogenesis in cultured dermal fibroblasts from patients with lysosomal beta-galactosidase, protective protein/cathepsin A and neuraminidase-1 deficiencies., PMID:16538002

Differential expression of endogenous sialidases of human monocytes during cellular differentiation into macrophages., PMID:15885103

Identification of a CTL4/Neu1 fusion transcript in a sialidosis patient., PMID:12067718

Intracellular distribution of lysosomal sialidase is controlled by the internalization signal in its cytoplasmic tail., PMID:11571282

Ganglioside control over IL-4 priming and cytokine production in activated T cells., PMID:10880242

Homoiogenetic Neural Induction in Xenopus Chimeric Explants: (Xenopus laevis/Xenopus borealis/chimeric explants/homoiogenetic neural induction/tissue-specific monoclonal antibodies)., PMID:37281176

Expression of Neural Antigens in Normal Xenopus Embryos and Induced Explants: (Xenopus laevis/neural antigens/monoclonal antibodies/neural induction/neural differentiation)., PMID:37280931

Evidence for placing the Neu-1 locus within the mouse H-2 complex., PMID:7119440

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