Catalog No.
PHN43401
Species reactivity
Human
Host species
Rabbit
Isotype
IgG
Clonality
Polyclonal
Immunogen
E. coli - derived recombinant Human ALKBH5 (Met1-His394).
Tested applications
ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000
Target
ALKBH5, ABH5, OFOXD1, RNA demethylase ALKBH5, Alkylated DNA repair protein alkB homolog 5, Alpha-ketoglutarate-dependent dioxygenase alkB homolog 5
Purification
Purified by antigen affinity column.
Accession
Q6P6C2
Applications
ELISA, IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
m6A eraser ALKBH5/treRNA1/DDX46 axis regulates BCR expression., PMID:39987653
RNA methylation of CD47 mediates tumor immunosuppression in EGFR-TKI resistant NSCLC., PMID:39900985
Lactylation of HDAC1 Confers Resistance to Ferroptosis in Colorectal Cancer., PMID:39888307
PRMT5-Mediated ALKBH5 Methylation Promotes Colorectal Cancer Immune Evasion via Increasing CD276 Expression., PMID:39781264
HSPA4 upregulation induces immune evasion via ALKBH5/CD58 axis in gastric cancer., PMID:38589927
The Molecular Basis of Human ALKBH3 Mediated RNA N1 -methyladenosine (m1 A) Demethylation., PMID:38158383
USF1-mediated ALKBH5 stabilizes FLII mRNA in an m6A-YTHDF2-dependent manner to repress glycolytic activity in prostate adenocarcinoma., PMID:37493109
ALKBH5 activates FAK signaling through m6A demethylation in ITGB1 mRNA and enhances tumor-associated lymphangiogenesis and lymph node metastasis in ovarian cancer., PMID:36632222
ALKBH5-Mediated m6A Demethylation of GLUT4 mRNA Promotes Glycolysis and Resistance to HER2-Targeted Therapy in Breast Cancer., PMID:36069931
m6A modification impacts hepatic drug and lipid metabolism properties by regulating carboxylesterase 2., PMID:34536357
RNA Demethylase FTO Mediated RNA m6A Modification Is Involved in Maintaining Maternal-Fetal Interface in Spontaneous Abortion., PMID:34350169
Integrated analysis of m6A mRNA methylation in rats with monocrotaline-induced pulmonary arterial hypertension., PMID:34310344
Regulatory Mechanisms of the RNA Modification m6A and Significance in Brain Function in Health and Disease., PMID:34093133
Rational Design of Novel Anticancer Small-Molecule RNA m6A Demethylase ALKBH5 Inhibitors., PMID:34056479
Identification and Characterization of N6-Methyladenosine CircRNAs and Methyltransferases in the Lens Epithelium Cells From Age-Related Cataract., PMID:32761139
ALKBH5 regulates anti-PD-1 therapy response by modulating lactate and suppressive immune cell accumulation in tumor microenvironment., PMID:32747553
Decreased Peripheral Blood ALKBH5 Correlates with Markers of Autoimmune Response in Systemic Lupus Erythematosus., PMID:32685056
Epitranscriptomics in liver disease: Basic concepts and therapeutic potential., PMID:32330603
Atlas of quantitative single-base-resolution N6-methyl-adenine methylomes., PMID:31822664
Development of formaldehyde dehydrogenase-coupled assay and antibody-based assays for ALKBH5 activity evaluation., PMID:30219599
Immuno-Northern Blotting: Detection of RNA Modifications by Using Antibodies against Modified Nucleosides., PMID:26606401
For research use only. Not for human or drug use.
