Catalog No.
PHG76801
Species reactivity
Human
Host species
Rabbit
Isotype
IgG
Clonality
Polyclonal
Immunogen
E. coli - derived recombinant Human CTTN (Met1-Asn491).
Tested applications
ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000
Target
Src substrate cortactin, Oncogene EMS1, CTTN, Amplaxin, EMS1
Purification
Purified by antigen affinity column.
Accession
Q14247
Applications
ELISA, IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Potential Biomarkers Associated with Prognosis and Trastuzumab Response in HER2+ Breast Cancer., PMID:37686651
A standardized extract of cultured Lentinula edodes mycelia downregulates cortactin in gemcitabine-resistant pancreatic cancer cells., PMID:34386076
Autoantibodies to cortactin and agrin in sera of patients with myasthenia gravis., PMID:33962172
[Not Available]., PMID:31082464
Optic Nerve Head Astrocytes Display Axon-Dependent and -Independent Reactivity in Response to Acutely Elevated Intraocular Pressure., PMID:30665231
Wnt5a causes ROR1 to complex and activate cortactin to enhance migration of chronic lymphocytic leukemia cells., PMID:30568170
TKS5-positive invadopodia-like structures in human tumor surgical specimens., PMID:30439350
Imatinib Alters Agonists-mediated Cytoskeletal Biomechanics in Lung Endothelium., PMID:29075042
Diagnostic utility of cortactin antibodies in myasthenia gravis., PMID:29068555
Fascin actin bundling controls podosome turnover and disassembly while cortactin is involved in podosome assembly by its SH3 domain in THP-1 macrophages and dendritic cells., PMID:25601713
Cortactin autoantibodies in myasthenia gravis., PMID:25193850
Identification of a novel myositis-associated antibody directed against cortactin., PMID:25182205
Serine phosphorylation of cortactin is required for maximal host cell invasion by Campylobacter jejuni., PMID:24188565
SRChing for the substrates of Src., PMID:24121272
Stabilization of actin bundles by a dynamin 1/cortactin ring complex is necessary for growth cone filopodia., PMID:23467367
Cortactin controls surface expression of the voltage-gated potassium channel K(V)10.1., PMID:23144454
Tyrosine phosphorylation of DEP-1/CD148 as a mechanism controlling Src kinase activation, endothelial cell permeability, invasion, and capillary formation., PMID:22898603
β₁Integrin/FAK/cortactin signaling is essential for human head and neck cancer resistance to radiotherapy., PMID:22378044
Mass spectrometric analysis identifies a cortactin-RCC2/TD60 interaction in mitotic cells., PMID:22282019
Photolysis of caged sphingosine-1-phosphate induces barrier enhancement and intracellular activation of lung endothelial cell signaling pathways., PMID:21478254
Cortactin phosphorylated by ERK1/2 localizes to sites of dynamic actin regulation and is required for carcinoma lamellipodia persistence., PMID:21079800
Regulation of sealing ring formation by L-plastin and cortactin in osteoclasts., PMID:20650888
Sphingosine-1-phosphate modulation of basal permeability and acute inflammatory responses in rat venular microvessels., PMID:20542878
Cortactin gene amplification and expression in breast cancer: a chromogenic in situ hybridisation and immunohistochemical study., PMID:20213079
Localization of cortactin is associated with colorectal cancer development., PMID:19885549
Disruption of the cytoskeleton during Semaphorin 3A induced growth cone collapse correlates with differences in actin organization and associated binding proteins., PMID:19513995
Overexpression of cortactin in head and neck squamous cell carcinomas can be uncoupled from augmented EGF receptor expression., PMID:18607838
Aberrant expression of cortactin and fascin are effective markers for pathogenesis, invasion, metastasis and prognosis of gastric carcinomas., PMID:18575752
CD44 regulates hepatocyte growth factor-mediated vascular integrity. Role of c-Met, Tiam1/Rac1, dynamin 2, and cortactin., PMID:17702746
Actin and Arf1-dependent recruitment of a cortactin-dynamin complex to the Golgi regulates post-Golgi transport., PMID:15821732
p47phox associates with the cytoskeleton through cortactin in human vascular smooth muscle cells: role in NAD(P)H oxidase regulation by angiotensin II., PMID:15618548
Alteration of podocytes in a murine model of crescentic glomerulonephritis., PMID:15258770
RNAi-mediated Hip1R silencing results in stable association between the endocytic machinery and the actin assembly machinery., PMID:14742709
Cortactin tyrosine phosphorylation requires Rac1 activity and association with the cortical actin cytoskeleton., PMID:12925758
Cryptosporidium parvum invasion of biliary epithelia requires host cell tyrosine phosphorylation of cortactin via c-Src., PMID:12851885
Changes in cytoskeletal and tight junctional proteins correlate with decreased permeability induced by dexamethasone in cultured rat brain endothelial cells., PMID:12782340
A Cortactin-CD2-associated protein (CD2AP) complex provides a novel link between epidermal growth factor receptor endocytosis and the actin cytoskeleton., PMID:12672817
Cortactin is a component of clathrin-coated pits and participates in receptor-mediated endocytosis., PMID:12612086
Cdc42/Rac1-dependent activation of the p21-activated kinase (PAK) regulates human platelet lamellipodia spreading: implication of the cortical-actin binding protein cortactin., PMID:12453877
The Src-cortactin pathway is required for clustering of E-selectin and ICAM-1 in endothelial cells., PMID:12060669
Primary arrest of circulating platelets on collagen involves phosphorylation of Syk, cortactin and focal adhesion kinase: studies under flow conditions., PMID:11988077
CD2AP and p130Cas localize to different F-actin structures in podocytes., PMID:11553524
Human cortactin as putative cancer antigen., PMID:11064458
Regulated interactions between dynamin and the actin-binding protein cortactin modulate cell shape., PMID:11018064
An invasion-related complex of cortactin, paxillin and PKCmu associates with invadopodia at sites of extracellular matrix degradation., PMID:10442635
Characterization of the EMS1 gene and its product, human Cortactin., PMID:9823470
Isolation and characterization of cortactin isoforms and a novel cortactin-binding protein, CBP90., PMID:9813110
The role of tyrosine phosphorylation of cortactin in the locomotion of endothelial cells., PMID:9748248
Cortactin localization in actin-containing adult and fetal tissues., PMID:9742075
Growth factor-dependent phosphorylation of the actin-binding protein cortactin is mediated by the cytoplasmic tyrosine kinase FER., PMID:9722593
For research use only. Not for human or drug use.
