Catalog No.
PHD27202
Species reactivity
Human, Mouse, Rat
Host species
Rabbit
Isotype
IgG
Clonality
Polyclonal
Immunogen
E. coli - derived recombinant Human IGFBP3 (Gly28-Lys291).
Tested applications
ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000
Target
IBP-3, Insulin-like growth factor-binding protein 3, IGF-binding protein 3, IBP3, IGFBP-3, IGFBP3
Purification
Purified by antigen affinity column.
Accession
P17936
Applications
ELISA, IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Pharmacodynamics, pharmacokinetics, and toxicology of Fc-growth hormone fusion protein in macaques., PMID:40120208
Antibodies against the receptor for insulin-like growth factor 1 (IGF-1RAb), insulin-like growth factor 1 (IGF-1), and insulin-like growth factor binding protein 3 (IGFBP-3) in the serum of patients with Graves' and Basedow's disease with and without orbitopathy., PMID:40071798
Cytokine profile of cerebrospinal fluid in pediatric patients with metastatic medulloblastoma., PMID:39524698
Characterization model of the post COVID-19 condition based on immunological, biochemical, and cytokine markers., PMID:39318534
IGF-2-mediated hypoglycemia: a case series and review of the medical therapies for refractory hypoglycemia., PMID:38432069
IGFBP3 induces PD-L1 expression to promote glioblastoma immune evasion., PMID:38326861
Differential effect of cancer-associated fibroblast-derived extracellular vesicles on cisplatin resistance in oral squamous cell carcinoma via miR-876-3p., PMID:38169528
IGF2BP3/HIF1A/YAP signaling plays a role in driving acute-on-chronic liver failure through activating hepatocyte reprogramming., PMID:37257765
Effects of leptin on the viability of human ovarian cancer cells and changes in cytokine expression levels., PMID:37155466
IGFBP-3 promotes cachexia-associated lipid loss by suppressing insulin-like growth factor/insulin signaling., PMID:37014770
Doxorubicin induced ROS-dependent HIF1α activation mediates blockage of IGF1R survival signaling by IGFBP3 promotes cardiac apoptosis., PMID:36602546
Opposing Roles of IGFBP-3 and Heparanase in Regulating A549 Lung Cancer Cell Survival., PMID:36428962
Prognostic value of comprehensive typing based on m6A and gene cluster in TNBC., PMID:36109402
Human amniotic mesenchymal stem cells-derived IGFBP-3, DKK-3, and DKK-1 attenuate liver fibrosis through inhibiting hepatic stellate cell activation by blocking Wnt/β-catenin signaling pathway in mice., PMID:35659360
Silica Induction of Diverse Inflammatory Proteome in Lungs of Lupus-Prone Mice Quelled by Dietary Docosahexaenoic Acid Supplementation., PMID:35126352
GH Responsiveness in Children With Noonan Syndrome Compared to Turner Syndrome., PMID:34858328
Gegen Qinlian Decoction ameliorates type 2 diabetes osteoporosis via IGFBP3/MAPK/NFATc1 signaling pathway based on cytokine antibody array., PMID:34798519
Atrial fibrillation: the role of hypoxia-inducible factor-1-regulated cytokines., PMID:33575876
Switching from originator recombinant growth hormone (Genotropin™) to biosimilar (CRISCY™): Results from a 6-month, multicentric, non-inferiority, extension trial., PMID:33260063
IGFBP-3 stimulates human osteosarcoma cell migration by upregulating VCAM-1 expression., PMID:33188835
Antibody microarray analysis of amniotic fluid proteins associated with subsequent ruptured membranes in women with threatened preterm labor., PMID:33155323
Human amniotic mesenchymal stem cells inhibit hepatocellular carcinoma in tumour-bearing mice., PMID:32798252
Identification and validation of differential plasma proteins levels in epithelial ovarian cancer., PMID:32634479
Silencing of NAMPT leads to up-regulation of insulin receptor substrate 1 gene expression in U87 glioma cells., PMID:32597148
Humanin Blocks the Aggregation of Amyloid-β Induced by Acetylcholinesterase, an Effect Abolished in the Presence of IGFBP-3., PMID:32383868
Serum Proteins as New Biomarkers for Whole-Body Exposure to High- and Low-LET Ionizing Radiation., PMID:32273832
Insulin-like growth factor-binding proteins play a significant role in the molecular response to imatinib in chronic myeloid leukemia patients., PMID:32104232
Effects of colostrum instead of formula feeding for the first 2 days postnatum on whole-body energy metabolism and its endocrine control in neonatal calves., PMID:32089303
Multiple Growth Factor Targeting by Engineered Insulin-like Growth Factor Binding Protein-3 Augments EGF Receptor Tyrosine Kinase Inhibitor Efficacy., PMID:32066763
High-performance detection of an abdominal aortic aneurysm biomarker by immunosensing., PMID:31876964
Maternal H. pylori seropositivity is associated with gestational hypertension but is irrelevant to fetal growth and development in early childhood., PMID:31842819
Model-Informed Dose Selection for Xentuzumab, a Dual Insulin-Like Growth Factor-I/II-Neutralizing Antibody., PMID:31562819
Cullin7 enhances resistance to trastuzumab therapy in Her2 positive breast cancer via degrading IRS-1 and downregulating IGFBP-3 to activate the PI3K/AKT pathway., PMID:31461670
Toxicogenomic analyses of the effects of BDE-47/209, TBBPA/S and TCBPA on early neural development with a human embryonic stem cell in vitro differentiation system., PMID:31326446
Sustained effect of continuous treatment with bevacizumab following bevacizumab in combination with chemotherapy in a human ovarian clear cell carcinoma xenograft model., PMID:31322247
Hormone replacement therapy in children with growth hormone deficiency: impact on immune profile., PMID:31215254
The IGF system in patients with inflammatory bowel disease treated with prednisolone or infliximab: potential role of the stanniocalcin-2 / PAPP-A / IGFBP-4 axis., PMID:31159802
Enhanced Anti-Cancer Effects of Conditioned Medium from Hypoxic Human Umbilical Cord-Derived Mesenchymal Stem Cells., PMID:31023003
Markers of Systemic Inflammation and Environmental Enteric Dysfunction Are Not Reduced by Zinc or Multivitamins in Tanzanian Infants: A Randomized, Placebo-Controlled Trial., PMID:30952509
Transcriptomics and Immunological Analyses Reveal a Pro-Angiogenic and Anti-Inflammatory Phenotype for Decidual Endothelial Cells., PMID:30935090
Comparison in transcriptome and cytokine profiles of mesenchymal stem cells from human umbilical cord and cord blood., PMID:30769140
Contrasting effects of IGF binding protein-3 expression in mammary tumor cells and the tumor microenvironment., PMID:30419192
Interaction of Insulin-Like Growth Factor-Binding Protein 3 With Hyaluronan and Its Regulation by Humanin and CD44., PMID:30184438
Modulation of Circulating Protein Biomarkers in Cancer Patients Receiving Bevacizumab and the Anti-Endoglin Antibody, TRC105., PMID:29997150
Randomized phase II trial of cixutumumab alone or with cetuximab for refractory recurrent/metastatic head and neck squamous cell carcinoma., PMID:29909907
Markers of Environmental Enteric Dysfunction Are Associated With Neurodevelopmental Outcomes in Tanzanian Children., PMID:29613921
Peptidyl-prolyl cis/trans isomerase Pin1 regulates withaferin A-mediated cell cycle arrest in human breast cancer cells., PMID:29603395
ISL1 overexpression enhances the survival of transplanted human mesenchymal stem cells in a murine myocardial infarction model., PMID:29482621
Insulin-like growth factor-1 (IGF1) in systemic lupus erythematosus: relation to disease activity, organ damage and immunological findings., PMID:29385899
Somapacitan, a once-weekly reversible albumin-binding GH derivative, in children with GH deficiency: A randomized dose-escalation trial., PMID:28656605
For research use only. Not for human or drug use.
