Catalog No.
PHJ32501
Species reactivity
Human
Host species
Rabbit
Isotype
IgG
Clonality
Polyclonal
Immunogen
E. coli - derived recombinant Human CD112/Nectin-2/NECTIN2 (Gln32-Pro350).
Tested applications
ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000
Target
Herpesvirus entry mediator B,Herpes virus entry mediator B,Nectin cell adhesion molecule 2,HVEB,PVRL2,Poliovirus receptor-related protein 2,CD112,PRR2,Nectin-2,HveB,NECTIN2
Purification
Purified by antigen affinity column.
Accession
Q92692
Applications
ELISA, IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Co-blocking TIGIT and PVRIG Using a Novel Bispecific Antibody Enhances Antitumor Immunity., PMID:39851063
CD34+ and CD34- MM cells show different immune-checkpoint molecule expression profiles: high expression of CD112 and CD137 ligand on CD34+ MM cells., PMID:39531203
Clinical response and pathway-specific correlates following TIGIT-LAG3 blockade in myeloma: the MyCheckpoint randomized clinical trial., PMID:39187595
CD112 Supports Lymphatic Migration of Human Dermal Dendritic Cells., PMID:38474388
Combined Blockade of TIGIT and PD-L1 Enhances Anti-Neuroblastoma Efficacy of GD2-Directed Immunotherapy with Dinutuximab Beta., PMID:37444427
Single-cell RNA sequencing highlights the role of PVR/PVRL2 in the immunosuppressive tumour microenvironment in hepatocellular carcinoma., PMID:37383234
Emergence of the CD226 Axis in Cancer Immunotherapy., PMID:35812451
TgMab-2: An Anti-human T Cell Immunoglobulin and Immunoreceptor Tyrosine-Based Inhibitory Motif Domain Monoclonal Antibody for Immunocytochemistry., PMID:35736625
Gene of the month: T-cell immunoreceptor with immunoglobulin and ITIM domains (TIGIT)., PMID:35058314
A reporter gene assay for determining the biological activity of therapeutic antibodies targeting TIGIT., PMID:35024316
CD155 and CD112 as possible therapeutic targets of FLT3 inhibitors for acute myeloid leukemia., PMID:34992684
A descriptive analysis of non-human leukocyte antigens present in renal transplant donor-recipient pairs., PMID:34582968
Innate Immune Checkpoint Inhibitors: The Next Breakthrough in Medical Oncology?, PMID:33850005
CD112 Regulates Angiogenesis and T Cell Entry into the Spleen., PMID:33467729
Expansion of circulating peripheral TIGIT+CD226+ CD4 T cells with enhanced effector functions in dermatomyositis., PMID:33413573
TIGIT: a novel immunotherapy target moving from bench to bedside., PMID:30232519
Immune checkpoints PVR and PVRL2 are prognostic markers in AML and their blockade represents a new therapeutic option., PMID:29855615
TX99 Is a Neutralizing Monoclonal Antibody Against Mouse TIGIT., PMID:29648914
Development and Characterization of Novel Monoclonal Antibodies Against Human DNAM-1., PMID:28498033
Nectin-2 (CD112) Is Expressed on Outgrowth Endothelial Cells and Regulates Cell Proliferation and Angiogenic Function., PMID:27676263
Anti-CD155 and anti-CD112 monoclonal antibodies conjugated to a fluorescent mesoporous silica nanosensor encapsulating rhodamine 6G and fluorescein for sensitive detection of liver cancer cells., PMID:27301350
CD155 on HIV-Infected Cells Is Not Modulated by HIV-1 Vpu and Nef but Synergizes with NKG2D Ligands to Trigger NK Cell Lysis of Autologous Primary HIV-Infected Cells., PMID:27296670
Recombinant soluble CD226 protein directly inhibits cancer cell proliferation in vitro., PMID:24468679
CD226 protein is involved in immune synapse formation and triggers Natural Killer (NK) cell activation via its first extracellular domain., PMID:24451371
Nectin-3 (CD113) interacts with Nectin-2 (CD112) to promote lymphocyte transendothelial migration., PMID:24116228
Establishment and characterization of a novel anti-DNAM-1 monoclonal antibody., PMID:23600509
Crystal structure of cell adhesion molecule nectin-2/CD112 and its binding to immune receptor DNAM-1/CD226., PMID:22547693
Identification and functional analysis of ligands for natural killer cell activating receptors in colon carcinoma., PMID:22189020
The cell surface proteome of human mesenchymal stromal cells., PMID:21637820
Identification of endothelial cell junctional proteins and lymphocyte receptors involved in transendothelial migration of human effector memory CD4+ T cells., PMID:21191062
A novel interface consisting of homologous immunoglobulin superfamily members with multiple functions., PMID:20081873
[Preparation and characterization of monoclonal antibodies against human CD112 (Nectin2/PRR2)]., PMID:17428395
The switch from latent to productive infection in epstein-barr virus-infected B cells is associated with sensitization to NK cell killing., PMID:17079298
Mast cell costimulation by CD226/CD112 (DNAM-1/Nectin-2): a novel interface in the allergic process., PMID:16831868
PVR (CD155) and Nectin-2 (CD112) as ligands of the human DNAM-1 (CD226) activating receptor: involvement in tumor cell lysis., PMID:15607800
DNAM-1 and PVR regulate monocyte migration through endothelial junctions., PMID:15136589
Functional characterization of DNAM-1 (CD226) interaction with its ligands PVR (CD155) and nectin-2 (PRR-2/CD112)., PMID:15039383
Identification of PVR (CD155) and Nectin-2 (CD112) as cell surface ligands for the human DNAM-1 (CD226) activating molecule., PMID:12913096
Retinoid regulation of human cathepsin D gene expression., PMID:8639464
For research use only. Not for human or drug use.
