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Anti-IL31RA Polyclonal Antibody

Catalog #:   PHJ26601 Specific References (44) DATASHEET
Host species: Rabbit
Isotype: IgG
Applications: ELISA, IHC, WB
Accession: Q8NI17
Overview

Catalog No.

PHJ26601

Species reactivity

Human

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human IL31RA (Val130-Asp622).

Tested applications

ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000

Target

IL-31RA,Interleukin-31 receptor subunit alpha,IL31RA,hGLM-R,ZcytoR17,IL-31R-alpha,GPL,CRL3,Cytokine receptor-like 3,IL-31R subunit alpha,IL-31 receptor subunit alpha,Gp130-like receptor,GLM-R,Gp130-like monocyte receptor

Purification

Purified by antigen affinity column.

Accession

Q8NI17

Applications

ELISA, IHC, WB

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Data Image
  • WESTERN BLOT
    Recombinant Protein lysates were subjected to SDS PAGE followed by western blot with IL31RA antibody (PHJ26601) at 1 μg/ml.

    Lane 1: Recombinant protein

    Second Ab: Goat Anti-Rabbit IgG H&L Polyclonal antibody, HRP (PTB96431) at 0.1 μg/mL.

    Predict MW: 58 kDa
    Observed MW: 58 kDa
  • Immunocytochemistry/ Immunofluorescence
    IL31RA in H929 Cell Line.
    The H929 cells were fixed with 4% paraformaldehyde (20 min), and then blocked with 5% goat serum for 1h. And the cells were incubated for 2h at 37°C with IL31RA (PHJ26601) at 10.6 μg/ml. The section was then incubated with Goat Anti-Rabbit IgG (Alexa Fluor-488) preabsorbed at 1/100 dilution (Shown in green) for 1 hour at room temperature.Nuclear DNA was labelled with DAPI (shown in blue).
References

Pre- and Postnatal Development Study of Nemolizumab, a Humanized Anti-Interleukin-31 Receptor A Monoclonal Antibody, in Cynomolgus Monkey., PMID:39868832

A case of bullous pemphigoid following administration of anti-IL-31 receptor A antibody., PMID:38507442

Prurigo nodularis: new insights into pathogenesis and novel therapeutics., PMID:38345154

Phase 3 Trial of Nemolizumab in Patients with Prurigo Nodularis., PMID:37888917

Canine interleukin-31 binds directly to OSMRβ with higher binding affinity than to IL-31RA., PMID:37588794

[Pharmacological profiles and clinical findings of nemolizumab as treatment for pruritus associated with atopic dermatitis]., PMID:37121713

Blockage of the IL-31 Pathway as a Potential Target Therapy for Atopic Dermatitis., PMID:36839897

Nemolizumab: First Approval., PMID:35834124

Nemolizumab for atopic dermatitis., PMID:35412530

A New Era with the Development of Cytokine-Based Therapy for Pruritus., PMID:34801247

Interleukin-31 promotes fibrosis and T helper 2 polarization in systemic sclerosis., PMID:34642338

Interleukin-31 and Pruritic Skin., PMID:33924978

Efficacy and Safety of Nemolizumab for Treatment of Adult Atopic Dermatitis: A Meta-analysis of Randomized Clinical Trials., PMID:33876738

Anti-pruritic effect of nemolizumab in hemodialysis patients with uremic pruritus: a phase II, randomized, double-blind, placebo-controlled clinical study., PMID:33754202

Interleukin-31 Signaling Bridges the Gap Between Immune Cells, the Nervous System and Epithelial Tissues., PMID:33644104

Interleukin-31: The "itchy" cytokine in inflammation and therapy., PMID:33629401

Biologics for Atopic Dermatitis., PMID:33012322

Increased expression of in situ IL-31RA and circulating CXCL8 and CCL2 in pemphigus herpetiformis suggests participation of the IL-31 family in the pathogenesis of the disease., PMID:32531145

Feline Interleukin-31 Shares Overlapping Epitopes with the Oncostatin M Receptor and IL-31RA., PMID:32459958

IL-4 Augments IL-31/IL-31 Receptor Alpha Interaction Leading to Enhanced Ccl 17 and Ccl 22 Production in Dendritic Cells: Implications for Atopic Dermatitis., PMID:31434203

Pathophysiologic mechanisms of itch in bullous pemphigoid., PMID:31351883

IL-31 plays dual roles in lung inflammation in an OVA-induced murine asthma model., PMID:30647024

Novel systemic drugs in treatment of atopic dermatitis: results from phase II and phase III studies published in 2017/2018., PMID:30095475

Interleukin-31 and interleukin-31 receptor: New therapeutic targets for atopic dermatitis., PMID:29524262

Recent advances in atopic dermatitis., PMID:29273133

Emerging role of interleukin-31 and interleukin-31 receptor in pruritus in atopic dermatitis., PMID:28670717

Regulation of Th2 responses by different cell types expressing the interleukin-31 receptor., PMID:28428802

The IL-31/IL-31 receptor axis: general features and role in tumor microenvironment., PMID:28408397

Therapy with anti-interleukin-31 receptor A antibody for atopic dermatitis., PMID:28394466

Anti-Interleukin-31 Receptor A Antibody for Atopic Dermatitis., PMID:28249150

Interleukin-31 pathway and its role in atopic dermatitis: a systematic review., PMID:28145790

Human basophils are a source of - and are differentially activated by - IL-31., PMID:28000952

Cynomolgus monkey model of interleukin-31-induced scratching depicts blockade of human interleukin-31 receptor A by a humanized monoclonal antibody., PMID:27714851

Itch Management: Treatments under Development., PMID:27578074

ΔNp63 regulates IL-33 and IL-31 signaling in atopic dermatitis., PMID:26768665

The first trial of CIM331, a humanized antihuman interleukin-31 receptor A antibody, in healthy volunteers and patients with atopic dermatitis to evaluate safety, tolerability and pharmacokinetics of a single dose in a randomized, double-blind, placebo-controlled study., PMID:26409172

RET mutation p.S891A in a Chinese family with familial medullary thyroid carcinoma and associated cutaneous amyloidosis binding OSMR variant p.G513D., PMID:26356818

Th2 Cytokines Augment IL-31/IL-31RA Interactions via STAT6-dependent IL-31RA Expression., PMID:25847241

Anti-IL-31 receptor antibody is shown to be a potential therapeutic option for treating itch and dermatitis in mice., PMID:24946165

Inhibition of a novel fibrogenic factor Tl1a reverses established colonic fibrosis., PMID:24850426

Radiation response and regulation of apoptosis induced by a combination of TRAIL and CHX in cells lacking mitochondrial DNA: a role for NF-κB-STAT3-directed gene expression., PMID:21440540

IL-31-IL-31R interactions limit the magnitude of Th2 cytokine-dependent immunity and inflammation following intestinal helminth infection., PMID:19414760

Complete overlap of interleukin-31 receptor A and oncostatin M receptor beta in the adult dorsal root ganglia with distinct developmental expression patterns., PMID:16926070

[Interleukin-31. A messenger of T-cells inducing urticaria and eczema reactions]., PMID:15635736

Datasheet
$ 170
Product specifications
50 μg 170 100 μg 280

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For research use only. Not for human or drug use.

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Anti-IL31RA Polyclonal Antibody [PHJ26601]
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