Catalog No.
PHJ22801
Species reactivity
Human
Host species
Rabbit
Isotype
IgG
Clonality
Polyclonal
Immunogen
E. coli - derived recombinant Human CD177 (Cys133-Ser301).
Tested applications
ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000
Target
CD177,NB1 GP,HNA-2a,Human neutrophil alloantigen 2a,NB1,PRV-1,CD177 antigen,Polycythemia rubra vera protein 1,NB1 glycoprotein,PRV1
Purification
Purified by antigen affinity column.
Accession
Q8N6Q3
Applications
ELISA, IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Glycosylation-driven programs coordinate immunoregulatory and pro-angiogenic functions of myeloid-derived suppressor cells., PMID:40381622
The tumor cell killing capacity of head and neck cancer patient-derived neutrophils depends on tumor stage, gender and the antibody isotype., PMID:39306937
CD177 is a novel IgG Fc receptor and CD177 genetic variants affect IgG-mediated function., PMID:39131159
The CD177 c.1291A Allele Leads to a Loss of Membrane Expression and Mimics a CD177-Null Phenotype., PMID:38474126
CD177 is a novel IgG Fc receptor and CD177 genetic variants affect IgG-mediated function., PMID:38260289
Disease Activity and Tendency to Relapse in ANCA-Associated Vasculitis Are Reflected in Neutrophil and Intermediate Monocyte Frequencies., PMID:38213873
OMIP-100: A flow cytometry panel to investigate human neutrophil subsets., PMID:38179854
Transcriptomic identification of genes expressed in invasive S. aureus diabetic foot ulcer infection., PMID:37434783
Immune Profiling Panel Gene Set Identifies Critically Ill Patients With Low Monocyte Human Leukocyte Antigen-DR Expression: Preliminary Results From the REAnimation Low Immune Status Marker (REALISM) Study., PMID:36917594
Phenotyping and Genotyping of HNA: Prevalence, Risk of Alloimmunization, and HNA Incompatibilities in Indians., PMID:36818775
Protective α1-antitrypsin effects in autoimmune vasculitis are compromised by methionine oxidation., PMID:36125911
Competitively disrupting the neutrophil-specific receptor-autoantigen CD177:proteinase 3 membrane complex reduces anti-PR3 antibody-induced neutrophil activation., PMID:35063507
Human neutrophil antigen 2 sequence-based typing: Joining the hunt for the CD177 answer., PMID:34590317
Transfusion of target antigens to preimmunized recipients: a new mechanism in transfusion-related acute lung injury., PMID:34438443
Chronic E-Cigarette Aerosol Inhalation Alters the Immune State of the Lungs and Increases ACE2 Expression, Raising Concern for Altered Response and Susceptibility to SARS-CoV-2., PMID:34122126
Triggering Receptor Expressed on Myeloid Cells-1 Agonist Regulates Intestinal Inflammation via Cd177+ Neutrophils., PMID:33767714
Characterization of CD177-reactive iso- and auto-antibodies., PMID:33734454
Distinct Gene Expression Signatures Characterize Strong Clinical Responders Versus Nonresponders to Canakinumab in Children With Systemic Juvenile Idiopathic Arthritis., PMID:33452871
Multicenter Study on Differential Human Neutrophil Antigen 2 Expression and Underlying Molecular Mechanisms., PMID:33173457
Human neutrophil antigens: Nature, clinical significance and detection., PMID:32970372
Dynamics of Cardiac Neutrophil Diversity in Murine Myocardial Infarction., PMID:32811295
Increase expression of CD177 in Kawasaki disease., PMID:30943984
Novel findings in neutrophil biology and their impact on cardiovascular disease., PMID:30918936
Determination of Subset-Restricted Anti-neutrophil Cytoplasmic Antibodies (ANCA) by Immunofluorescence Cytochemistry., PMID:30539568
Molecular Genetics of the Human Neutrophil Antigens., PMID:30498408
Tumour-infiltrating neutrophils counteract anti-VEGF therapy in metastatic colorectal cancer., PMID:30377339
Interaction between CD177 and platelet endothelial cell adhesion molecule-1 downregulates membrane-bound proteinase-3 (PR3) expression on neutrophils and attenuates neutrophil activation induced by PR3-ANCA., PMID:30236159
The Role of Neonatal Gr-1+ Myeloid Cells in a Murine Model of Rhesus-Rotavirus-Induced Biliary Atresia., PMID:30201498
CD117 Expression in Squamous Cell Carcinoma of the Oesophagus., PMID:29970514
Flow-Cytometric Analysis of HNA-2 Expression and Phenotypes Among Thai Blood Donors., PMID:29611387
Anti-human neutrophil antigen-1a, -1b, and -2 antibodies in neonates and children with immune neutropenias analyzed by extracted granulocyte antigen immunofluorescence assay., PMID:28833244
[Gastrointestinal stromal tumor and renal transplant]., PMID:28825581
CD177 modulates human neutrophil migration through activation-mediated integrin and chemoreceptor regulation., PMID:28807980
Characterization of the CD177 interaction with the ANCA antigen proteinase 3., PMID:28240246
IL-17RB+ granulocytes are associated with airflow obstruction in asthma., PMID:27979026
Prolonged neutropenia due to antihuman neutrophil antigen 2 (CD177) antibody after bone marrow transplantation., PMID:27905683
A sequence-specific polymerase chain reaction method for HNA-2 genotyping: homozygous c.843A>T mutation predicts the absence of CD177., PMID:27385476
Lessons from a double-transgenic neutrophil approach to induce antiproteinase 3 antibody-mediated vasculitis in mice., PMID:27365530
Heterogeneity of Human Neutrophil CD177 Expression Results from CD177P1 Pseudogene Conversion., PMID:27227454
Rapid characterization of hybridomas producing monoclonal antibodies against platelet β3 integrin using ELIspot., PMID:27185103
Intermediate monocytes in ANCA vasculitis: increased surface expression of ANCA autoantigens and IL-1β secretion in response to anti-MPO antibodies., PMID:26149790
HNA antibody-mediated neutrophil aggregation is dependent on serine protease activity., PMID:26084778
Geno- and phenotyping of human neutrophil antigens., PMID:26024636
Impaired phagocytosis and reactive oxygen species production in phagocytes is associated with systemic vasculitis., PMID:27102815
Differential expression of granulopoiesis related genes in neutrophil subsets distinguished by membrane expression of CD177., PMID:24926686
Neutropenia associated with antihuman neutrophil antibodies following allogeneic hematopoietic stem cell transplantation., PMID:24237009
External quality assessment of human neutrophil antigen (HNA)-specific antibody detection and HNA genotyping from 2000 to 2012., PMID:23663230
Gene expression profiling of whole blood in ipilimumab-treated patients for identification of potential biomarkers of immune-related gastrointestinal adverse events., PMID:23521917
[Biomarkers associated with unresponsiveness to IVIG in children with Kawasaki disease]., PMID:23445729
Identifying patients with neutrophil elastase (ELANE) mutations from patients with a presumptive diagnosis of autoimmune neutropenia., PMID:23206890
For research use only. Not for human or drug use.
