Catalog No.
PMJ84001
Species reactivity
Mouse
Host species
Rabbit
Isotype
IgG
Clonality
Polyclonal
Immunogen
E. coli - derived recombinant Mouse JAG2 (Met27-Asn201).
Tested applications
ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000
Target
Protein jagged-2, hJ2, Jagged2, JAG2
Purification
Purified by antigen affinity column.
Accession
Q9QYE5
Applications
ELISA, IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Immunosuppressive JAG2+ tumor-associated neutrophils hamper PD-1 blockade response in ovarian cancer by mediating the differentiation of effector regulatory T cells., PMID:40120139
The Jag2/Notch1 signaling axis promotes sebaceous gland differentiation and controls progenitor proliferation., PMID:39585329
Jagged2 targeting in lung cancer activates anti-tumor immunity via Notch-induced functional reprogramming of tumor-associated macrophages., PMID:38636522
Notch ligands are biomarkers of anti-TNF response in RA patients., PMID:37796367
Osteosarcoma-Associated Immune Genes as Potential Immunotherapy and Prognosis Biomarkers., PMID:37452172
Assemblies of JAG1 and JAG2 determine tracheobronchial cell fate in mucosecretory lung disease., PMID:35819850
Anti-Jagged-1 immunotherapy in cancer., PMID:35421813
Involvement of muscle satellite cell dysfunction in neuromuscular disorders: Expanding the portfolio of satellite cell-opathies., PMID:35302338
Relationship of Notch Signal, Surfactant Protein A, and Indomethacin in Cervix During Preterm Birth: Mast Cell and Jagged-2 May Be Key in Understanding Infection-mediated Preterm Birth., PMID:34927491
Delta-like 1-Expressing Cells at the Gland Base Promote Proliferation of Gastric Antral Stem Cells in Mouse., PMID:34438113
Tumour-associated neutrophils orchestrate intratumoural IL-8-driven immune evasion through Jagged2 activation in ovarian cancer., PMID:32778818
Overexpression of JAG2 is related to poor outcomes in oral squamous cell carcinoma., PMID:32250571
Precision medicine for human cancers with Notch signaling dysregulation (Review)., PMID:31894255
Notch Ligand Binding Assay Using Flow Cytometry., PMID:29333477
Genetic prediction of the effectiveness of biologics for psoriasis treatment., PMID:27129929
Therapeutic antibodies reveal Notch control of transdifferentiation in the adult lung., PMID:26580007
Notch3-Jagged signaling controls the pool of undifferentiated airway progenitors., PMID:25564622
NOTCH decoys that selectively block DLL/NOTCH or JAG/NOTCH disrupt angiogenesis by unique mechanisms to inhibit tumor growth., PMID:25387766
Integrative genetic, epigenetic and pathological analysis of paraganglioma reveals complex dysregulation of NOTCH signaling., PMID:23955600
Bone marrow-derived CD11b+Jagged2+ cells promote epithelial-to-mesenchymal transition and metastasization in colorectal cancer., PMID:23722542
Specific Notch receptor-ligand interactions control human TCR-αβ/γδ development by inducing differential Notch signal strength., PMID:23530123
Jagged2-signaling promotes IL-6-dependent transplant rejection., PMID:23526606
P4 down-regulates Jagged2 and Notch1 expression during primordial folliculogenesis., PMID:22652674
Expression of Notch receptors and ligands on immature and mature T cells., PMID:22310713
Notch-ligand expression by NALT dendritic cells regulates mucosal Th1- and Th2-type responses., PMID:22200492
MTHFR and MSX1 contribute to the risk of nonsyndromic cleft lip/palate., PMID:20572854
Characterization of Notch1 antibodies that inhibit signaling of both normal and mutated Notch1 receptors., PMID:20161710
Notch-Hes1 pathway contributes to the cochlear prosensory formation potentially through the transcriptional down-regulation of p27Kip1., PMID:19598246
Differential regulation of splenic CD8- dendritic cells and marginal zone B cells by Notch ligands., PMID:19181931
Mature human eosinophils express functional Notch ligands mediating eosinophil autocrine regulation., PMID:19171875
Notch1 signals through Jagged2 to regulate apoptosis in the apical ectodermal ridge of the developing limb bud., PMID:16245338
Overexpression of the NOTCH ligand JAG2 in malignant plasma cells from multiple myeloma patients and cell lines., PMID:15292061
Transit-amplifying ductular (oval) cells and their hepatocytic progeny are characterized by a novel and distinctive expression of delta-like protein/preadipocyte factor 1/fetal antigen 1., PMID:15039222
Induction of Notch signaling by tumor necrosis factor in rheumatoid synovial fibroblasts., PMID:14586405
Expression of Notch1 and Jagged2 in the enteric nervous system., PMID:12810847
Replication and subnuclear location dynamics of the immunoglobulin heavy-chain locus in B-lineage cells., PMID:12052893
Cortisol regulates the expression of Notch in osteoblasts., PMID:11948681
Expression of Notch ligands, Jagged1, 2 and Delta1 in antigen presenting cells in mice., PMID:11841846
Requirement of Notch 1 and its ligand jagged 2 expressions for spermatogenesis in rat and human testes., PMID:11700865
Human ligands of the Notch receptor., PMID:10079256
For research use only. Not for human or drug use.
