Catalog No.
PHH86501
Species reactivity
Human
Host species
Rabbit
Isotype
IgG
Clonality
Polyclonal
Immunogen
E. coli - derived recombinant Human SEZ6 (Cys416-Val704).
Tested applications
ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000
Target
Seizure protein 6 homolog, SEZ-6, hSEZ-6, SEZ6
Purification
Purified by antigen affinity column.
Accession
Q53EL9
Applications
ELISA, IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Soluble VCAM-1 may serve as a pharmacodynamic CSF marker to monitor BACE2 activity in non-human primates., PMID:40480341
Assessment of targets of antibody drug conjugates in SCLC., PMID:39748112
Detection of SEZ6, a therapeutic target, in medullary thyroid carcinoma., PMID:39324657
A Phase I First-in-Human Study of ABBV-011, a Seizure-Related Homolog Protein 6-Targeting Antibody-Drug Conjugate, in Patients with Small Cell Lung Cancer., PMID:39287821
Antibody-drug conjugates treatment of small cell lung cancer: advances in clinical research., PMID:39090431
Preclinical Characterization of Catabolic Pathways and Metabolism of ABBV-011, a Novel Calicheamicin-Based SEZ6-Targeting Antibody-Drug Conjugate., PMID:38050039
Unlocking New Horizons in Small-Cell Lung Cancer Treatment: The Onset of Antibody-Drug Conjugates., PMID:38001628
ABBV-011, A Novel, Calicheamicin-Based Antibody-Drug Conjugate, Targets SEZ6 to Eradicate Small Cell Lung Cancer Tumors., PMID:35642431
Click Chemistry-mediated Biotinylation Reveals a Function for the Protease BACE1 in Modulating the Neuronal Surface Glycoproteome., PMID:29716987
Seizure protein 6 and its homolog seizure 6-like protein are physiological substrates of BACE1 in neurons., PMID:27716410
Analysis of the Cerebrospinal Fluid Proteome in Alzheimer's Disease., PMID:26950848
The distribution of the seizure-related gene 6 (Sez-6) protein during postnatal development of the mouse forebrain suggests multiple functions for this protein: an analysis using a new antibody., PMID:21334315
Seizure-related gene 6 (Sez-6) in amacrine cells of the rodent retina and the consequence of gene deletion., PMID:19662096
Cloning and characterization of seizure-related gene, SEZ-6., PMID:7488116
For research use only. Not for human or drug use.
