Catalog No.
PHJ05701
Species reactivity
Human, Mouse, Rat
Host species
Rabbit
Isotype
IgG
Clonality
Polyclonal
Immunogen
E. coli - derived recombinant Human SIGIRR (Met1-His118).
Tested applications
ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000
Target
TIR8,Toll/interleukin-1 receptor 8,Single Ig IL-1R-related molecule,Single Ig IL-1-related receptor,Single immunoglobulin domain-containing IL1R-related protein,SIGIRR
Purification
Purified by antigen affinity column.
Accession
Q6IA17
Applications
ELISA, IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Short-chain fatty acids ameliorate necrotizing enterocolitis-like intestinal injury through enhancing Notch1-mediated single immunoglobulin interleukin-1-related receptor, toll-interacting protein, and A20 induction., PMID:36410023
Molecular characterization and functional analysis of DIGIRR from golden pompano (Trachinotus ovatus)., PMID:36091048
Dominant-Negative Form of SIGIRR: SIGIRRΔE8 Promotes Tumor Growth Through Regulation of Metabolic Pathways., PMID:35900274
A Promising Genetic Target for a Deadly Disease: Single Immunoglobulin Interleukin 1 (SIGIRR) Mutations in Necrotizing Enterocolitis., PMID:34740617
SIGIRR Mutation in Human Necrotizing Enterocolitis (NEC) Disrupts STAT3-Dependent microRNA Expression in Neonatal Gut., PMID:34563711
Single Immunoglobulin IL-1-Related Receptor (SIGIRR) Gene rs7396562 Polymorphism and Expression Level in Rheumatoid Arthritis., PMID:34036103
IL-37 Represses the Autoimmunity in Myasthenia Gravis via Directly Targeting Follicular Th and B Cells., PMID:32111731
IL1R8 Deficiency Drives Autoimmunity-Associated Lymphoma Development., PMID:31018956
Characterization of a long isoform of IL-1R8 (TIR8/SIGIRR)., PMID:28840837
Expression of Toll-like receptor signaling-related genes in pigs co-infected with porcine reproductive and respiratory syndrome virus and porcine circovirus type 2., PMID:26022073
Transcriptomic signatures in whole blood of patients who acquire a chronic inflammatory response syndrome (CIRS) following an exposure to the marine toxin ciguatoxin., PMID:25889530
α-TLR2 antibody attenuates the Aβ-mediated inflammatory response in microglia through enhanced expression of SIGIRR., PMID:25620736
Absence of Toll-IL-1 receptor 8/single immunoglobulin IL-1 receptor-related molecule reduces house dust mite-induced allergic airway inflammation in mice., PMID:23614768
The largely normal response to Toll-like receptor 7 and 9 stimulation and the enhanced expression of SIGIRR by B cells in systemic lupus erythematosus., PMID:22952899
Immunobiotic Lactobacillus jensenii modulates the Toll-like receptor 4-induced inflammatory response via negative regulation in porcine antigen-presenting cells., PMID:22573738
TREM-1 amplifies corneal inflammation after Pseudomonas aeruginosa infection by modulating Toll-like receptor signaling and Th1/Th2-type immune responses., PMID:21555403
Interleukin-1alpha and HMGB1 mediate hippocampal dysfunction in SIGIRR-deficient mice., PMID:21389242
SIGIRR/TIR-8 is an inhibitor of Toll-like receptor signaling in primary human cells and regulates inflammation in models of rheumatoid arthritis., PMID:20506350
Evidence for a DC-specific inhibitory mechanism that depends on MyD88 and SIGIRR., PMID:20500691
TIR8 receptor expression in bovine tissues., PMID:20227770
The single IgG IL-1-related receptor controls TLR responses in differentiated human intestinal epithelial cells., PMID:20130217
Lack of SIGIRR/TIR8 aggravates hydrocarbon oil-induced lupus nephritis., PMID:20112371
Nph, DC and chromatin-mediated pathogenesis in systemic lupus erythematosus., PMID:19811268
Tir8/Sigirr prevents murine lupus by suppressing the immunostimulatory effects of lupus autoantigens., PMID:18644972
Damping excessive inflammation and tissue damage in Mycobacterium tuberculosis infection by Toll IL-1 receptor 8/single Ig IL-1-related receptor, a negative regulator of IL-1/TLR signaling., PMID:17709526
Identification and characterization of SIGIRR, a molecule representing a novel subtype of the IL-1R superfamily., PMID:10346978
For research use only. Not for human or drug use.
