Anti-ZC3H12A Polyclonal Antibody

Catalog No.

PHH98701

Species reactivity

Human, Mouse, Rat

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human ZC3H12A (Asp426-Glu599).

Tested applications

ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000

Target

Regnase-1,MCPIP,Endoribonuclease ZC3H12A,Reg1,MCPIP-1,MCP-induced protein 1,ZC3H12A,Zinc finger CCCH domain-containing protein 12A,MCPIP1,Monocyte chemotactic protein-induced protein 1

Purification

Purified by antigen affinity column.

Accession

Q5D1E8

Applications

ELISA, IHC, WB

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Epithelial Regnase-1 inhibits colorectal tumor growth by regulating IL-17 signaling via degradation of NFKBIZ mRNA., PMID:40460118

MCPIP-1 knockdown enhances endothelial colony-forming cell angiogenesis via the TFRC/AKT/mTOR signaling pathway in the ischemic penumbra of MCAO mice., PMID:37689231

Regnase-1 Prevents Pulmonary Arterial Hypertension Through mRNA Degradation of Interleukin-6 and Platelet-Derived Growth Factor in Alveolar Macrophages., PMID:35997026

CD40×HER2 bispecific antibody overcomes the CCL2-induced trastuzumab resistance in HER2-positive gastric cancer., PMID:35851310

RTEC-intrinsic IL-17-driven inflammatory circuit amplifies antibody-induced glomerulonephritis and is constrained by Regnase-1., PMID:34236049

Murine myeloid cell MCPIP1 suppresses autoimmunity by regulating B-cell expansion and differentiation., PMID:33737335

Deletion of Mcpip1 in Mcpip1fl/flAlbCre mice recapitulates the phenotype of human primary biliary cholangitis., PMID:33513427

Monocyte Chemotactic Protein 1-Induced Protein 1 Is Highly Expressed in Inflammatory Bowel Disease and Negatively Regulates Neutrophil Activities., PMID:33488293

IFI16 contributes to the pathogenesis of abdominal aortic aneurysm by regulating the caspase-1/IL-1β/MCPIP1 pathway., PMID:33188834

Immune homeostasis and regulation of the interferon pathway require myeloid-derived Regnase-3., PMID:31126966

Targeting Interleukin-6 Signaling in Clinic., PMID:30995492

Pulmonary Regnase-1 orchestrates the interplay of epithelium and adaptive immune systems to protect against pneumonia., PMID:29695841

MCPIP1 RNase Is Aberrantly Distributed in Psoriatic Epidermis and Rapidly Induced by IL-17A., PMID:27180111

Blood Transcriptome Profiling in Myasthenia Gravis Patients to Assess Disease Activity: A Pilot RNA-seq Study., PMID:26924932

Simultaneous detection of mRNA and protein in single cells using immunofluorescence-combined single-molecule RNA FISH., PMID:26458549

Posttranscriptional T cell gene regulation to limit Tfh cells and autoimmunity., PMID:26432764

MCPIP1 deficiency in mice results in severe anemia related to autoimmune mechanisms., PMID:24324805

Endothelial dysfunction in rheumatoid arthritis: the role of monocyte chemotactic protein-1-induced protein., PMID:23580143

Post-transcriptional regulation of IL-6 production by Zc3h12a in fibroblast-like synovial cells., PMID:22132693

Zc3h12a is an RNase essential for controlling immune responses by regulating mRNA decay., PMID:19322177

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