Catalog No.
YMF86301
Expression system
E. coli
Species
Mus musculus (Mouse)
Protein length
Asn32-Gly329
Predicted molecular weight
36.14 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P21183
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
IL-5R subunit alpha, IL-5 receptor subunit alpha, IL5RA, IL-5RA, IL-5R-alpha, Interleukin-5 receptor subunit alpha, CDw125, CD125, IL5R
Remarkable increase in Interleukin-5 receptor expression beyond tissue eosinophils in inflammatory bowel disease., PMID:40475764
Exogenous binding immunoglobulin protein (BiP) enhance immune regulatory phenotype in ex-vivo Mtb infected PBMCs stratified based on QuantiFERON response., PMID:39671882
Effect of benralizumab on inflammation in skin after intradermal allergen challenge in patients with moderate-to-severe atopic dermatitis., PMID:39234416
Interactions between eosinophils and IL-5Rα-positive mast cells in nonadvanced systemic mastocytosis., PMID:39151478
Serum Concentration of IL-5 Receptor (IL-5R) and Associations with Disease Severity in Patients with Chronic Spontaneous Urticaria (CSU) and Atopic Dermatitis (AD)., PMID:39062845
Eosinophils, basophils and myeloid-derived suppressor cells in chronic Loa loa infection and its treatment in an endemic setting., PMID:38771861
Benralizumab versus Mepolizumab for Eosinophilic Granulomatosis with Polyangiitis., PMID:38393328
Epithelial IL5RA promotes epithelial-mesenchymal transition in pulmonary fibrosis via Jak2/STAT3 cascade., PMID:38191068
The Study of the Influence of IL5RA Variants on Chronic Obstructive Pulmonary Disease., PMID:37905709
IL5RA as an immunogenic cell death-related predictor in progression and therapeutic response of multiple myeloma., PMID:37236993
Amanita muscaria extract potentiates production of proinflammatory cytokines by dsRNA-activated human microglia., PMID:37124206
Optimized flow cytometry protocol for dihydrorhodamine 123-based detection of reactive oxygen species in leukocyte subpopulations in whole blood., PMID:35760097
High proportion of inflammatory CD62Llow eosinophils in blood and nasal polyps of severe asthma patients., PMID:35490414
Are serum immunoglobulin concentrations a predictive biomarker of response to anti-IL5/IL5Rα therapies?, PMID:34983012
Transcriptional Regulation of the Human IL5RA Gene through Alternative Promoter Usage during Eosinophil Development., PMID:34638583
Interleukin-5 receptor alpha (CD125) expression on human blood and lung neutrophils., PMID:34391897
Mepolizumab targets multiple immune cells in aspirin-exacerbated respiratory disease., PMID:34144111
The efficacy of off-label IL-5-modulating treatment in rare eosinophil-mediated diseases., PMID:33779559
Molecular mechanism of asthma and its novel molecular target therapeutic agent., PMID:33549541
Engineering of Humanized Antibodies Against Human Interleukin 5 Receptor Alpha Subunit That Cause Potent Antibody-Dependent Cell-Mediated Cytotoxicity., PMID:33488590
Genomic and phenotypic characterization of Investigator Global Assessment (IGA) scale-based endotypes in atopic dermatitis., PMID:33421484
Unsustained Response to Benralizumab in Eosinophilic Asthma After 3 Years of Therapy With Mepolizumab., PMID:33136004
Efficacy of Benralizumab and Clinical Course of IgG4 in Eosinophilic Granulomatosis With Polyangiitis., PMID:33030432
MiRNA-495-3p Attenuates TNF-α Induced Apoptosis and Inflammation in Human Nucleus Pulposus Cells by Targeting IL5RA., PMID:32445070
IL-5Rα marks nasal polyp IgG4- and IgE-expressing cells in aspirin-exacerbated respiratory disease., PMID:32199912
Eosinophils, the IL-5/IL-5Rα axis, and the biologic effects of benralizumab in severe asthma., PMID:31734469
Eosinophils Affect Antibody Isotype Switching and May Partially Contribute to Early Vaccine-Induced Immunity against Coxiella burnetii., PMID:31427447
Expression of IL-5 receptor alpha by murine and human lung neutrophils., PMID:31415658
Targeting IL-5 in COPD., PMID:31190789
A case of severe eosinophilic asthma and refractory rheumatoid arthritis well controlled by combination of IL-5Rα antibody and TNFα inhibitor., PMID:31027977
Longitudinal trends of serum IgE and IL5RA expression throughout childhood are associated with asthma but not with persistent wheeze., PMID:31012487
Benralizumab for PDGFRA-Negative Hypereosinophilic Syndrome., PMID:30943337
Epigenome-wide meta-analysis of DNA methylation and childhood asthma., PMID:30579849
Reslizumab Compared with Benralizumab in Patients with Eosinophilic Asthma: A Systematic Literature Review and Network Meta-Analysis., PMID:30217529
Killer (FASL regulatory) B cells are present during latent TB and are induced by BCG stimulation in participants with and without latent tuberculosis., PMID:29523310
Benralizumab for the treatment of asthma., PMID:29517082
FACS isolation of live mouse eosinophils at high purity via a protocol that does not target Siglec F., PMID:29253503
Epigenome-wide association study of asthma and wheeze in childhood and adolescence., PMID:29046734
Multiomics Approach to Asthma: Navigating the Network., PMID:28960106
A Multiomics Approach to Identify Genes Associated with Childhood Asthma Risk and Morbidity., PMID:28574721
Oral Glucocorticoid-Sparing Effect of Benralizumab in Severe Asthma., PMID:28530840
Human group 2 innate lymphoid cells do not express the IL-5 receptor., PMID:28502824
Targeting Interleukin-5 or Interleukin-5Rα: Safety Considerations., PMID:28321782
B-cells with a FasL expressing regulatory phenotype are induced following successful anti-tuberculosis treatment., PMID:28250925
Efficacy and Safety of Benralizumab, a Monoclonal Antibody against IL-5Rα, in Uncontrolled Eosinophilic Asthma., PMID:27119985
Successful TB treatment induces B-cells expressing FASL and IL5RA mRNA., PMID:27682872
A rational approach for cancer stem-like cell isolation and characterization using CD44 and prominin-1(CD133) as selection markers., PMID:27655682
The role of interleukin 5 in asthma., PMID:27450970
Disentangling the effects of tocilizumab on neutrophil survival and function., PMID:26721805
For research use only. Not for human or drug use.
