Catalog No.
YMD19401
Expression system
E. coli
Species
Mus musculus (Mouse)
Protein length
Ser39-Glu231
Predicted molecular weight
24.54 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P16872
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
IL7R, Interleukin-7 receptor subunit alpha, IL-7R-alpha, IL-7 receptor subunit alpha, CD127, CDw127, IL-7R subunit alpha, IL-7RA
Development of an in situ CAR-T cell protocol through optical and PSMA-targeted PET imaging., PMID:40493195
Low-dose radiation by radiopharmaceutical therapy enhances GD2 TRAC-CAR T cell efficacy in localized neuroblastoma., PMID:40465728
Dynamics and immunological signature of γδ T cells following antiretroviral therapy initiation in acute HIV-1 Infection., PMID:40406103
Dose Optimization of rhIL-7-hyFc for Patients With Lymphopenia Using a Neonatal Fc Receptor-Mediated Recycling-Based and Target-Mediated Drug Disposition Pharmacokinetic Model., PMID:40396986
The Human Bone Marrow May Offer an IL-15-Dependent Survival Niche for EOMES+ Tr1-Like Cells., PMID:40375822
An elevated percentage of CD4⁺CD25⁺CD127low regulatory T cells in peripheral blood indicates a poorer prognosis in hepatocellular carcinoma after curative hepatectomy., PMID:40335903
IL-7 in autoimmune diseases: mechanisms and therapeutic potential., PMID:40313966
Reduced interleukin-2 receptor subunit γ expression in Crohn's disease: A potential mechanism for γδ T cell deficiency., PMID:40248067
Deficiency of IL-7R attenuates abdominal aortic aneurysms in mice by inhibiting macrophage polarization towards M1 phenotype through the NF-κB pathway., PMID:40240976
Role of Regulatory T Cells in Chronic Obstructive Pulmonary Disease., PMID:40226513
Quantitative Assessment of T-Regulatory Cell Population and FOXP3 Gene Expression in Chronically Exposed Residents of the Urals Region., PMID:40216726
Decreased gene expression of interleukin 2 receptor subunit γ (CD132) in tissues of patients with Crohn's disease., PMID:40182599
Functional insights of an uncommon hypomorphic variant in IL2RG as a monogenic cause of CVID-like disease with antibody deficiency and T CD4 lymphopenia., PMID:40170851
Construction of enhanced MRI-based radiomics models using machine learning algorithms for non-invasive prediction of IL7R expression in high-grade gliomas and its prognostic value in clinical practice., PMID:40165301
Higher proportions of circulating CXCR3+ CCR6- Tfh cells as a hallmark of impaired CD4+ T-cell recovery in HIV-1-infected immunological non-responders., PMID:40130906
Decreased circulating CD39+ regulatory T cell frequencies following non-traumatic brain death., PMID:40118258
ApoE ε4-dependent Alteration of CXCR3 + CD127+ CD4+ T cells associates with elevated plasma neurofilament light chain in Alzheimer's disease., PMID:40112322
IL-7Rα signaling in regulatory T cells of adipose tissue is essential for systemic glucose homeostasis., PMID:40107286
Humanized Mouse Model of Graft-Versus-Host Disease Utilizing Nonirradiated NOD-scid-IL-2Rγnull Mice., PMID:40100599
T cell receptor usage and epitope specificity amongst CD8+ and CD4+ SARS-CoV-2-specific T cells., PMID:40092978
Pre-B-cell leukemia transcription factor 1 contributes to liver fibrosis by enabling IL-7 signaling in HSC., PMID:40080840
Fc-mediated immune stimulating, pro-inflammatory and antitumor effects of anti-HER2 IgE against HER2-expressing and trastuzumab-resistant tumors., PMID:40074330
LAMP2-FLOT2 interaction enhances autophagosome-lysosome fusion to protect the septic heart in response to ILC2., PMID:40066518
In vitro differentiation of common lymphoid progenitor cells into B cell using stromal cell free culture system., PMID:40038600
Cytotoxic KLRG1+ IL-7R- effector CD8+ T cells distinguish kidney transplant recipients controlling cytomegalovirus reactivation., PMID:40028342
Collaboration between interleukin-7 and -15 enables adaptation of tissue-resident and circulating memory CD8+ T cells to cytokine deficiency., PMID:40023156
Causal Association Between Inflammatory Proteins, Inflammatory Cells, and Cauda Equina Syndrome: A Two-Sample Mendelian Randomization., PMID:40020998
Th1-poised naive CD4 T cell subpopulation reflects anti-tumor immunity and autoimmune disease., PMID:40000667
Genome-wide KAS-Seq mapping of leukocytes in ischemia-reperfusion model reveals IL7R as a potential therapeutic target for ischemia-reperfusion injury., PMID:39979392
Surface pTα expression predicts LCK activation and preclinical synergy of LCK and JAK coinhibition in adult T-ALL., PMID:39977715
Ruxolitinib synergizes with regulatory T cells to improve inflammation but has no added benefits in decreasing albuminuria in SLE., PMID:39975551
The development and potent antitumor efficacy of CD44/CD133 dual-targeting IL7Rα-armored CAR-T cells against glioblastoma., PMID:39952598
Transvitreal Retinochoroidal Biopsies of Primary Uveal Melanoma Reveal an Association of Low HLA Class I and High NK Cell Abundance in Low-Risk Disease., PMID:39918475
Phase I study of efineptakin alfa (NT-I7) for the treatment of Kaposi sarcoma., PMID:39915263
A self-activated and protective module enhances the preclinical performance of allogeneic anti-CD70 CAR-T cells., PMID:39906740
A Phenotypically Distinct Human Th2 Cell Subpopulation Is Associated With Development of Allergic Disorders in Infancy., PMID:39899007
CD8+T cells and monocytes were associated with brain alterations in human immunodeficiency virus-infected individuals with cognitive impairment., PMID:39892581
Regulatory B-Cells Are Associated Negatively With Regulatory T-Cells and Positively With Cytokines in Peripheral Blood of Pregnant Women., PMID:39854121
OMIP-110: A 37-Color Spectral Flow Cytometric Panel to Assess Transcription Factors and Chemokine Receptors in Human Intestinal Lymphoid Cells., PMID:39838760
IL-7 secreted by keratinocytes induces melanogenesis via c-kit/MAPK signaling pathway in Melan-a melanocytes., PMID:39825949
Adaptive immune cells antagonize ILC2 homeostasis via SLAMF3 and SLAMF5., PMID:39792675
Preimplantation genetic testing for four families with severe combined immunodeficiency: Three unaffected livebirths., PMID:39789600
An early precursor CD8+ T cell that adapts to acute or chronic viral infection., PMID:39778710
Optimized BCMA/CS1 bispecific TRuC-T cells secreting IL-7 and CCL21 robustly control multiple myeloma., PMID:39776916
Direct Inhibitory Effect of HTLV-1-Infected T Cells on the Production of Anti-Ro/SS-A Antibody by B Cells from Patients with Sjögren's Syndrome., PMID:39775490
New insights into roles of IL-7R gene as a diagnostic biomarker for post-stroke depression., PMID:39763672
Dynamic P-glycoprotein expression in early and late memory states of human CD8 + T cells and the protective role of ruxolitinib., PMID:39740391
TLS and immune cell profiling: immunomodulatory effects of immunochemotherapy on tumor microenvironment in resectable stage III NSCLC., PMID:39726591
The role of TIGIT-CD226-PVR axis in mediating T cell exhaustion and apoptosis in NSCLC., PMID:39725799
A minority of Th1 and Tfh effector cells express survival genes shared by memory cell progeny that require IL-7 or TCR signaling to persist., PMID:39723889
For research use only. Not for human or drug use.
