Catalog No.
YHF64102
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Arg200-Arg390
Predicted molecular weight
23.85 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P78325
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Disintegrin and metalloproteinase domain-containing protein 8, ADAM8, CD156a, MS2, Cell surface antigen MS2, ADAM 8
Potential prognostic and immunologic significances of ADAM8 in clear cell renal cell carcinoma., PMID:39889162
TFAP2A Activates ADAM8 to Promote Lung Adenocarcinoma Angiogenesis Through the JAK/STAT Signaling Pathway., PMID:39812116
Extracellular Release of a Disintegrin and Metalloproteinase Correlates With Periodontal Disease Severity., PMID:39317350
Association of ADAM family members with proliferation signaling and disease progression in multiple myeloma., PMID:39261477
METTL14-mediated lncRNA-FAS-AS1 promotes osteoarthritis progression by up-regulating ADAM8., PMID:39221886
PSGL-1, ADAM8, and selectins as potential biomarkers in the diagnostic process of systemic lupus erythematosus and systemic sclerosis: an observational study., PMID:39100683
Identification of a novel macrophage-related prognostic signature in colorectal cancer., PMID:38307957
ADAM8 silencing suppresses the migration and invasion of fibroblast-like synoviocytes via FSCN1/MAPK cascade in osteoarthritis., PMID:38218854
A jack of all trades - ADAM8 as a signaling hub in inflammation and cancer., PMID:38097912
Development of a 5-mRNAsi-related gene signature to predict the prognosis of colon adenocarcinoma., PMID:38025763
Knockdown of ADAM8 inhibits the proliferation, migration, invasion, and tumorigenesis of renal clear cell carcinoma cells to enhance the immunotherapy efficacy., PMID:37992987
A prognostic model based on tumor microenvironment and immune cell in colorectal cancer., PMID:37978827
Identification of angiogenesis-related subtypes, the development of a prognosis model, and features of tumor microenvironment in colon cancer., PMID:37881150
Identification of Novel Core Genes Involved in Malignant Transformation of Inflamed Colon Tissue Using a Computational Biology Approach and Verification in Murine Models., PMID:36901742
Brain metastasis in breast cancer: focus on genes and signaling pathways involved, blood-brain barrier and treatment strategies., PMID:36897508
Changes of gene expression in peripheral blood mononuclear cells of lung cancer patients with or without anorexia., PMID:36473427
ALG3 Promotes Peritoneal Metastasis of Ovarian Cancer through Increasing Interaction of α1,3-mannosylated uPAR and ADAM8., PMID:36231102
Comprehensive bioinformatics analyses reveal immune genes responsible for altered immune microenvironment in intervertebral disc degeneration., PMID:35767190
Progression of cerebral white matter hyperintensities is related to leucocyte gene expression., PMID:35325079
ADAM8-Dependent Extracellular Signaling in the Tumor Microenvironment Involves Regulated Release of Lipocalin 2 and MMP-9., PMID:35216088
Three Potential Tumor Markers Promote Metastasis and Recurrence of Colorectal Cancer by Regulating the Inflammatory Response: ADAM8, LYN, and S100A9., PMID:35103068
Prospective evaluation of 92 serum protein biomarkers for early detection of ovarian cancer., PMID:35031764
Leukocyte Membrane Enzymes Play the Cell Adhesion Game., PMID:34887854
Propofol mediates pancreatic cancer cell activity through the repression of ADAM8 via SP1., PMID:34617574
Transcriptomic studies revealed pathophysiological impact of COVID-19 to predominant health conditions., PMID:34076249
Identification of biomarkers related to Tumor-Infiltrating Lymphocytes (TILs) infiltration with gene co-expression network in colorectal cancer., PMID:33960283
TrkB/C-induced HOXC6 activation enhances the ADAM8-mediated metastasis of chemoresistant colon cancer cells., PMID:33846772
ADAM8 affects glioblastoma progression by regulating osteopontin-mediated angiogenesis., PMID:33544472
Activity and components of the granulocyte colony-stimulating factor pathway in hidradenitis suppurativa., PMID:33400270
Quantitative Imaging of MS2-Tagged hTR in Cajal Bodies: Photobleaching and Photoactivation., PMID:33377008
ADAM 8 as a novel target for doxorubicin delivery to TNBC cells using magnetic thermosensitive liposomes., PMID:33338603
A disintegrin and metalloproteinase 8 induced epithelial-mesenchymal transition to promote the invasion of colon cancer cells via TGF-β/Smad2/3 signalling pathway., PMID:32954649
Propofol affects the growth and metastasis of pancreatic cancer via ADAM8., PMID:32048249
Clinical and Radiographic Assessment of Single or Combined Treatment with Lepidium sativum and Alendronate of Non-Surgically Treated Chronic Periodontitis in Postmenopausal Osteoporotic Women., PMID:31522159
A Disintegrin and Metalloproteinase 8 as a Potential Blood Biomarker for Early Diagnosis of Gastric Cancer., PMID:31347325
ADAM8 promotes chondrosarcoma cell migration and invasion by activating the NF-κB/MMP-13 signaling axis., PMID:31305294
Molecular profiling of the tumor microenvironment in glioblastoma patients: correlation of microglia/macrophage polarization state with metalloprotease expression profiles and survival., PMID:31142630
ADAM8 in the cardiovascular system: An innocent bystander with clinical use?, PMID:31003630
Elevated expression of the metalloproteinase ADAM8 associates with vascular diseases in mice and humans., PMID:30910225
Propofol inhibits pancreatic cancer proliferation and metastasis by up-regulating miR-328 and down-regulating ADAM8., PMID:30861616
Metalloprotease inhibitor profiles of human ADAM8 in vitro and in cell-based assays., PMID:30738011
ADAM8 in invasive cancers: links to tumor progression, metastasis, and chemoresistance., PMID:30635388
Reduced ADAM8 levels upon non-surgical periodontal therapy in patients with chronic periodontitis., PMID:30384155
ADAM8 localizes to extravillous trophoblasts within the maternal-fetal interface and potentiates trophoblast cell line migration through a β1 integrin-mediated mechanism., PMID:30124911
A Disintegrin and Metalloproteinase Domain-8: A Novel Protective Proteinase in Chronic Obstructive Pulmonary Disease., PMID:29750543
Deregulated PSGL-1 Expression in B Cells and Dendritic Cells May Be Implicated in Human Systemic Sclerosis Development., PMID:29689251
ADAM8 Is an Antigen of Tyrosine Kinase Inhibitor-Resistant Chronic Myeloid Leukemia Cells Identified by Patient-Derived Induced Pluripotent Stem Cells., PMID:29429960
ADAM8 expression in breast cancer derived brain metastases: Functional implications on MMP-9 expression and transendothelial migration in breast cancer cells., PMID:28986926
Whole body and hematopoietic ADAM8 deficiency does not influence advanced atherosclerotic lesion development, despite its association with human plaque progression., PMID:28916789
Profiling of metalloprotease activities in cerebrospinal fluids of patients with neoplastic meningitis., PMID:28806983
For research use only. Not for human or drug use.
