Anti-IRF4 Polyclonal Antibody

Catalog No.

PHH06201

Species reactivity

Human, Mouse, Rat

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human IRF4 (Glu130-Glu451).

Tested applications

ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000

Target

IRF-4,NF-EM5,MUM1,LSIRF,IRF4,Multiple myeloma oncogene 1,Interferon regulatory factor 4,Lymphocyte-specific interferon regulatory factor

Purification

Purified by antigen affinity column.

Accession

Q15306

Applications

ELISA, IHC, WB

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

IL16 Promotes Plasma Cell Differentiation., PMID:40495388

Distinct plasmablast developmental intermediates produce graded expression of IgM secretory transcripts., PMID:39923238

Myricetin exposure reduces PC differentiation in vitro in primary human B cells., PMID:39875809

Antisense oligonucleotides-based approaches for the treatment of multiple myeloma., PMID:39732226

Interleukin-2-secreting T helper cells promote extra-follicular B cell maturation via intrinsic regulation of a B cell mTOR-AKT-Blimp-1 axis., PMID:39612915

Interferon Regulatory Factor 4: An Alternative Marker for Plasma Cells in Daratumumab-Treated Patients With Multiple Myeloma., PMID:39267340

Transcriptional function of E2A, Ebf1, Pax5, Ikaros and Aiolos analyzed by in vivo acute protein degradation in early B cell development., PMID:39179932

Inhibition of GRK2 ameliorates the pristane-induced mouse SLE model by suppressing plasma cells differentiation., PMID:38936060

Jagged2 targeting in lung cancer activates anti-tumor immunity via Notch-induced functional reprogramming of tumor-associated macrophages., PMID:38636522

Accelerated plasma-cell differentiation in Bach2-deficient mouse B cells is caused by altered IRF4 functions., PMID:38605225

ETS translocation variant 5 (ETV5) promotes CD4+ T cell-mediated intestinal inflammation and fibrosis in inflammatory bowel diseases., PMID:38555025

Stochastic modeling of a gene regulatory network driving B cell development in germinal centers., PMID:38547073

Transcriptomic Analysis Reveals Sixteen Potential Genes Associated with the Successful Differentiation of Antibody-Secreting Cells through the Utilization of Unfolded Protein Response Mechanisms in Robust Responders to the Influenza Vaccine., PMID:38400120

Therapeutic vaccine-induced plasma cell differentiation is defective in the presence of persistently high HBsAg levels., PMID:38336348

Large B-cell Lymphoma with IRF4 Rearrangement in the Nasolacrimal Duct: A Clinicopathological Study of One Case and Literature Review., PMID:38279752

Construction of a molecular inflammatory predictive model with histone modification-related genes and identification of CAMK2D as a potential response signature to infliximab in ulcerative colitis., PMID:38274809

Clinical efficacy and biomarker analysis of neoadjuvant camrelizumab plus chemotherapy for early-stage triple-negative breast cancer: a experimental single-arm phase II clinical trial pilot study., PMID:38116673

Editorial: Mechanisms of dysregulated antibody responses in inborn errors of immunity., PMID:38077378

Human inborn errors of immunity associated with IRF4., PMID:37809068

Roles of interferon regulatory factor 4 in the AKI-CKD transition, glomerular diseases and kidney allograft rejection., PMID:37755331

Case report: Clinicopathological and molecular characteristics of pediatric-type follicular lymphoma., PMID:37539011

Inhibition of PI3K p110δ activity reduces IgE production in IL-4 and anti-CD40 stimulated human B cell cultures., PMID:37530226

Sphingosylphosphorylcholine inhibits plasma cell differentiation and ameliorates experimental autoimmune encephalomyelitis., PMID:37409121

Toll-like receptor mediated inflammation directs B cells towards protective antiviral extrafollicular responses., PMID:37407556

Deciphering the Genetic Code of Autoimmune Kidney Diseases., PMID:37239388

A Genetic Risk Score Distinguishes Different Types of Autoantibody-Mediated Membranous Nephropathy., PMID:37090184

Antigen-specific B cells direct T follicular-like helper cells into lymphoid follicles to mediate Mycobacterium tuberculosis control., PMID:37012543

Investigation of the anti-tumor mechanism of tirabrutinib, a highly selective Bruton's tyrosine kinase inhibitor, by phosphoproteomics and transcriptomics., PMID:36897912

Probiotics Alleviate Food Protein Allergy in Mice by Activating TLR4 Signaling Pathway., PMID:36815217

IL-21R signal reprogramming cooperates with CD40 and BCR signals to select and differentiate germinal center B cells., PMID:36800413

CCL17 Blockade by CCL17mAb/GSK-J4 Ameliorates Hyperalgesia in a Rat Model of Postoperative Pain., PMID:36792181

IL-9-Producing Th9 Cells Participate in the Occurrence and Development of Iodine-Induced Autoimmune Thyroiditis., PMID:36773201

B cell-intrinsic DNase1L3 is essential for the T cell-independent type II response in mice., PMID:36689362

A CRISPR/Cas9-mediated screen identifies determinants of early plasma cell differentiation., PMID:36685499

Successful Treatment of Large B-Cell Lymphoma in a Child with Compound Heterozygous Mutation in the ATM Gene., PMID:36674612

A multimorphic mutation in IRF4 causes human autosomal dominant combined immunodeficiency., PMID:36662884

B cell- and T cell-intrinsic regulation of germinal centers by thymic stromal lymphopoietin signaling., PMID:36608149

Exploring novel functions of BACH2 in the acquisition of antigen-specific antibodies., PMID:36573315

Citrulline enteral administration markedly reduces immunosuppressive extrafollicular plasma cell differentiation in a preclinical model of sepsis., PMID:36564641

A p38α-BLIMP1 signalling pathway is essential for plasma cell differentiation., PMID:36443297

The transcription factor E2A can bind to and cleave single-stranded immunoglobulin heavy chain locus DNA., PMID:36434987

Prolactin promotes proliferation of germinal center B cells, formation of plasma cells, and elevated levels of IgG3 anti-dsDNA autoantibodies., PMID:36389691

Blau syndrome NOD2 mutations result in loss of NOD2 cross-regulatory function., PMID:36189261

Comprehensive CRISPR-Cas9 screen identifies factors which are important for plasmablast development., PMID:36189249

Regulatory network of BLIMP1, IRF4, and XBP1 triad in plasmacytic differentiation and multiple myeloma pathogenesis., PMID:36081178

Treatment with a JAK1/2 inhibitor ameliorates murine autoimmune cholangitis induced by IFN overexpression., PMID:36042351

Changes in Th9 and Th17 lymphocytes and functional cytokines and their relationship with thyroid-stimulating hormone receptor antibodies at different stages of graves' disease., PMID:35935994

Peripheral CD23hi/IgE+ Plasmablasts Secrete IgE and Correlate with Allergic Disease Severity., PMID:35896336

Detection and Characterization of Paraproteinemia in Canine Chronic B-cell Lymphocytic Leukemia Using Routine and Free Light Chain Immunofixation., PMID:35883213

Essential Transcription Factors and Functional Roles of Follicular Helper T Cells ‎in Human Autoimmune Diseases., PMID:35767886

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