Catalog No.
PHG99501
Species reactivity
Human, Mouse, Rat
Host species
Rabbit
Isotype
IgG
Clonality
Polyclonal
Immunogen
E. coli - derived recombinant Human SETDB1 (Met1-Ser350).
Tested applications
ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000
Target
H3-K9-HMTase 4,ESET,SETDB1,SET domain bifurcated 1,Histone H3-K9 methyltransferase 4,KMT1E,KIAA0067,Lysine N-methyltransferase 1E,ERG-associated protein with SET domain,Histone-lysine N-methyltransferase SETDB1
Purification
Purified by antigen affinity column.
Accession
Q15047
Applications
ELISA, IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
H3K14ac facilitates the reinstallation of constitutive heterochromatin in Drosophila early embryos by engaging Eggless/SetDB1., PMID:39437264
Genome-Wide CRISPR/Cas9 Screening Unveils a Novel Target ATF7IP-SETDB1 Complex for Enhancing Difficult-to-Express Protein Production., PMID:38240694
SETDB1-mediated CD147-K71 di-methylation promotes cell apoptosis in non-small cell lung cancer., PMID:37692516
Targeting intracellular proteins with cell type-specific functions for cancer immunotherapy., PMID:39872303
Nuclear AREG affects a low-proliferative phenotype and contributes to drug resistance of melanoma., PMID:36054710
Epigenetic comparison of CHO hosts and clones reveals divergent methylation and transcription patterns across lineages., PMID:35028935
Immunochemical Detection of Modified Cytosine Species in Mammalian Preimplantation Embryos., PMID:32822029
Blocking histone methyltransferase SETDB1 inhibits tumorigenesis and enhances cetuximab sensitivity in colorectal cancer., PMID:32473242
Application of dual reading domains as novel reagents in chromatin biology reveals a new H3K9me3 and H3K36me2/3 bivalent chromatin state., PMID:28946896
Subsets of Visceral Adipose Tissue Nuclei with Distinct Levels of 5-Hydroxymethylcytosine., PMID:27171244
Analysis of the subcellular localization of the human histone methyltransferase SETDB1., PMID:26296461
The histone methyltransferase ESET is required for the survival of spermatogonial stem/progenitor cells in mice., PMID:24763053
Roles of histone H3K9 methyltransferases during Drosophila spermatogenesis., PMID:22476432
Characterization of HIV Tat modifications using novel methyl-lysine-specific antibodies., PMID:20615470
SETDB1: a novel KAP-1-associated histone H3, lysine 9-specific methyltransferase that contributes to HP1-mediated silencing of euchromatic genes by KRAB zinc-finger proteins., PMID:11959841
For research use only. Not for human or drug use.
