Catalog No.
RHB54002
Species reactivity
Human
Host species
Human
Isotype
IgG1, kappa
Clonality
Monoclonal
Target
Tumor necrosis factor ligand superfamily member 15, TNF ligand-related molecule 1, Vascular endothelial cell growth inhibitor, Tumor necrosis factor ligand superfamily member 15, membrane form, Tumor necrosis factor ligand superfamily member 15, secreted form, TNFSF15, TL1, VEGI
Concentration
4.52 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
O95150
Applications
ELISA, FCM, Neutralization
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
3B3
TL1A as a Target in Inflammatory Bowel Disease: Exploring Mechanisms and Therapeutic Potential., PMID:40507829
Japanese Phase 1 Study for Global Development of Anti-TL1A Antibody PF-06480605: A Randomized, Placebo-Controlled, Single-Ascending Dose Study., PMID:40065559
TL1A, a novel alarmin in airway, intestinal, and autoimmune disorders., PMID:40010414
Phase 2 Trial of Anti-TL1A Monoclonal Antibody Tulisokibart for Ulcerative Colitis., PMID:39321363
Targeting TNFRSF25 by agonistic antibodies and multimeric TL1A proteins co-stimulated CD8+ T cells and inhibited tumor growth., PMID:39142717
Antibodies Targeting the Tumor Necrosis Factor-Like Ligand 1A in Inflammatory Bowel Disease: A New Kid on the (Biologics) Block?, PMID:39068930
Anti-TL1A monoclonal antibody modulates the dysregulation of Th1/Th17 cells and attenuates granuloma formation in sarcoidosis by inhibiting the PI3K/AKT signaling pathway., PMID:38852524
TL1A and IL-18 synergy promotes GM-CSF-dependent thymic granulopoiesis in mice., PMID:38839915
TL1A inhibition for inflammatory bowel disease treatment: From inflammation to fibrosis., PMID:38574740
Roles of tumor necrosis factor-like ligand 1A in γδT-cell activation and psoriasis pathogenesis., PMID:38348035
Seven chromatin regulators as immune cell infiltration characteristics, potential diagnostic biomarkers and drugs prediction in hepatocellular carcinoma., PMID:37903974
Genome-wide association analyses define pathogenic signaling pathways and prioritize drug targets for IgA nephropathy., PMID:37337107
Protective efficacy induced by Eimeria maxima rhomboid-like protein 1 against homologous infection., PMID:36686197
Anti-TLR7 Antibody Protects Against Lupus Nephritis in NZBWF1 Mice by Targeting B Cells and Patrolling Monocytes., PMID:34868046
A novel 10-gene immune-related lncRNA signature model for the prognosis of colorectal cancer., PMID:34814366
Effect and Mechanism of TL1A Expression on Epithelial-Mesenchymal Transition during Chronic Colitis-Related Intestinal Fibrosis., PMID:34257516
The relationship between TNF-like protein 1A and coronary artery aneurysms in children with Kawasaki disease., PMID:34232416
TL1A (TNFSF15) genotype affects the long-term therapeutic outcomes of anti-TNFα antibodies for Crohn's disease patients., PMID:33319044
Design, development, and evaluation of the efficacy of a nucleic acid-free version of a bacterial ghost candidate vaccine against avian pathogenic E. coli (APEC) O78:K80 serotype., PMID:33298146
Signaling in TNFSF15-mediated Suppression of VEGF Production in Endothelial Cells., PMID:33185864
TL1A-DR3 Plasma Levels Are Predictive of HIV-1 Disease Control, and DR3 Costimulation Boosts HIV-1-Specific T Cell Responses., PMID:33177161
Bevacizumab-Conjugated Quantum Dots: In Vitro Antiangiogenic Potential and Biosafety in Rat Retina., PMID:32522096
Circulating TNF-like protein 1A (TL1A) is elevated early in rheumatoid arthritis and depends on TNF., PMID:32381123
Role of RANK-L as a potential inducer of ILC2-mediated type 2 inflammation in chronic rhinosinusitis with nasal polyps., PMID:31641233
Activation of the DR3-TL1A Axis in Donor Mice Leads to Regulatory T Cell Expansion and Activation With Reduction in Graft-Versus-Host Disease., PMID:31379829
Association of Tumor Necrosis Like factor 1 A (TL1A) and its Decoy Receptor (DcR3) with The Disease Activity and Autoantibody Production in Rheumatoid Arthritis Patients., PMID:31332995
TL1A modulates the severity of colitis by promoting Th9 differentiation and IL-9 secretion., PMID:31176785
TL1A (TNFSF15) and DR3 (TNFRSF25): A Co-stimulatory System of Cytokines With Diverse Functions in Gut Mucosal Immunity., PMID:30972074
A role for BATF3 in TH9 differentiation and T-cell-driven mucosal pathologies., PMID:30617301
Death-Domain-Receptor 3 Deletion Normalizes Inflammatory Gene Expression and Prevents Ileitis in Experimental Crohn's Disease., PMID:30295722
Reduced monocyte and macrophage TNFSF15/TL1A expression is associated with susceptibility to inflammatory bowel disease., PMID:30199539
Aggregates of IVIG or Avastin, but not HSA, modify the response to model innate immune response modulating impurities., PMID:30065306
TNFSF15 is likely a susceptibility gene for systemic lupus erythematosus., PMID:29803925
An anti-TL1A antibody for the treatment of asthma and inflammatory bowel disease., PMID:29436901
TL1A blocking ameliorates intestinal fibrosis in the T cell transfer model of chronic colitis in mice., PMID:29254800
Hydrogen/deuterium exchange mass spectrometry and computational modeling reveal a discontinuous epitope of an antibody/TL1A Interaction., PMID:29135326
DcR3 promotes hepatoma cell migration by downregulating E-cadherin expression., PMID:28560426
Association of Ribonuclease T2 Gene Polymorphisms With Decreased Expression and Clinical Characteristics of Severity in Crohn's Disease., PMID:28400196
Marked in Vivo Donor Regulatory T Cell Expansion via Interleukin-2 and TL1A-Ig Stimulation Ameliorates Graft-versus-Host Disease but Preserves Graft-versus-Leukemia in Recipients after Hematopoietic Stem Cell Transplantation., PMID:28219835
TNFSF15 suppresses VEGF production in endothelial cells by stimulating miR-29b expression via activation of JNK-GATA3 signals., PMID:27589684
Serum decoy receptor 3 levels are associated with the disease activity of MPO-ANCA-associated renal vasculitis., PMID:27251675
Interleukin‑12B is upregulated by decoy receptor 3 in rheumatoid synovial fibroblasts., PMID:26956410
Expression and function of the TL1A/DR3 axis in chronic lymphocytic leukemia., PMID:26393680
Tumor Necrosis Factor-like Cytokine TL1A and Its Receptors DR3 and DcR3: Important New Factors in Mucosal Homeostasis and Inflammation., PMID:26099067
Tumour necrosis factor superfamily member 15 (Tnfsf15) facilitates lymphangiogenesis via up-regulation of Vegfr3 gene expression in lymphatic endothelial cells., PMID:26096340
Effects of dietary selenium on host response to necrotic enteritis in young broilers., PMID:25575447
Dietary sodium selenite affects host intestinal and systemic immune response and disease susceptibility to necrotic enteritis in commercial broilers., PMID:25387235
Death receptor 3 mediates TNFSF15- and TNFα-induced endothelial cell apoptosis., PMID:25161149
Effects of salinomycin and Bacillus subtilis on growth performance and immune responses in broiler chickens., PMID:25135491
Inhibition of a novel fibrogenic factor Tl1a reverses established colonic fibrosis., PMID:24850426
For research use only. Not for human or drug use.
