Catalog No.
YHG14202
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Ala20-Gly292
Predicted molecular weight
31.98 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q07954-2
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Isoform 2 of Prolow-density lipoprotein receptor-related protein 1, LRP-1, Alpha-2-macroglobulin receptor, A2MR, Apolipoprotein E receptor, APOER, CD91, Low-density lipoprotein receptor-related protein 1 85 kDa subunit, LRP-85, Low-density lipoprotein receptor-related protein 1 515 kDa subunit, LRP-515, Low-density lipoprotein receptor-related protein 1 intracellular domain, LRPICD, LRP1, A2MR, APR
Identification of potential cell surface targets in patient-derived cultures toward photoimmunotherapy of high-grade serous ovarian cancer., PMID:40205302
Peripheral monocyte subsets are altered during gestation in oocyte donation pregnancy complicated with pre-eclampsia., PMID:39920890
Recombinant human heavy-chain ferritin nanoparticles loaded with rosuvastatin attenuates secondary brain injury in intracerebral hemorrhage., PMID:39894117
CD91-mediated reprogramming of DCs by immunogenic heat shock proteins requires the kinases AXL and Fgr., PMID:39696592
Lrp1 facilitates infection of neurons by Jamestown Canyon virus., PMID:39574651
The Atlantic Cod MHC I compartment has the properties needed for cross-presentation in the absence of MHC II., PMID:39455705
CD91 and Its Ligand gp96 Confer Cross-Priming Capabilities to Multiple APCs during Immune Responses to Nascent, Emerging Tumors., PMID:39269437
Development of a Humanized Antibody Targeting Extracellular HSP90α to Suppress Endothelial-Mesenchymal Transition-Enhanced Tumor Growth of Pancreatic Adenocarcinoma Cells., PMID:38994997
A reactive monocyte subset characterized by low expression of CD91 is expanded during sterile and septic inflammation., PMID:38278526
Immunoregulatory function of SP-A., PMID:38244369
Free heme induces neuroinflammation and cognitive impairment by microglial activation via the TLR4/MyD88/NF-κB signaling pathway., PMID:38183122
Clearance of Neutrophils From ICH-Affected Brain by Macrophages Is Beneficial and Is Assisted by Lactoferrin and CD91., PMID:38063014
Assessment of inter-operator variability in peripheral monocyte subset gating strategy using flow cytometry in patients with suspected acute stroke., PMID:37971361
Pseudomonas aeruginosa-Derived DnaJ Induces the Expression of IL-1β by Engaging the Interplay of p38 and ERK Signaling Pathways in Macrophages., PMID:37958940
Marine natural product lepadin A as a novel inducer of immunogenic cell death via CD91-dependent pathway., PMID:37779162
Complement C1q essential for aeroallergen sensitization via CSF1R+ conventional dendritic cells type 2., PMID:37562753
Airway macrophages display decreased expression of receptors mediating and regulating scavenging in early cystic fibrosis lung disease., PMID:37457715
Suppression of osteosarcoma progression by engineered lymphocyte-derived proteomes., PMID:37397541
Low-density lipoprotein receptor-related protein-1 (LRP1) in the glial lineage modulates neuronal excitability., PMID:37383546
Multi-faceted role of LRP1 in the immune system., PMID:37020553
Heme Scavenging and Delivery: The Role of Human Serum Albumin., PMID:36979511
SARS-CoV-2 Induces Epithelial-Enteric Neuronal Crosstalk Stimulating VIP Release., PMID:36830577
Human Decidual CD1a+ Dendritic Cells Undergo Functional Maturation Program Mediated by Gp96., PMID:36768601
Structures of LRP2 reveal a molecular machine for endocytosis., PMID:36750096
Circulating exosomal immuno-oncological checkpoints and cytokines are potential biomarkers to monitor tumor response to anti-PD-1/PD-L1 therapy in non-small cell lung cancer patients., PMID:36741391
YO2 Induces Melanoma Cell Apoptosis through p53-Mediated LRP1 Downregulation., PMID:36612285
Leukocyte surface biomarkers implicate deficits of innate immunity in sporadic Alzheimer's disease., PMID:36349985
The LRP1/CD91 ligands, tissue-type plasminogen activator, α2-macroglobulin, and soluble cellular prion protein have distinct co-receptor requirements for activation of cell-signaling., PMID:36266319
Interference of immunogenic chemotherapy by artificially controlled calreticulin secretion from tumor cells., PMID:36064229
Heat Shock Protein 90's Mechanistic Role in Contact Hypersensitivity., PMID:35675957
Deep immunophenotyping reveals endometriosis is marked by dysregulation of the mononuclear phagocytic system in endometrium and peripheral blood., PMID:35421980
Extracellular HMGB1 Impairs Macrophage-Mediated Efferocytosis by Suppressing the Rab43-Controlled Cell Surface Transport of CD91., PMID:35392093
Agents of cancer immunosurveillance: HSPs and dsDNA., PMID:35382994
Extracellular HSP90α Induces MyD88-IRAK Complex-Associated IKKα/β-NF-κB/IRF3 and JAK2/TYK2-STAT-3 Signaling in Macrophages for Tumor-Promoting M2-Polarization., PMID:35053345
Single-cell RNA sequencing deconvolutes the in vivo heterogeneity of human bone marrow-derived mesenchymal stem cells., PMID:34803492
Tunable heat shock protein-mediated NK cell responses are orchestrated by STAT1 in Antigen Presenting Cells., PMID:34373574
CD91 Derived Treg Epitope Modulates Regulatory T Lymphocyte Response, Regulates Expression of Costimulatory Molecules on Antigen-Presenting Cells, and Rescues Pregnancy in Mouse Pregnancy Loss Model., PMID:34298914
LRP1/CD91 is highly expressed in monocytes from patients with vitiligo - even after repigmentation., PMID:33249636
Role of collectin-11 in innate defence against uropathogenic Escherichia coli infection., PMID:33241978
Complement C1q Interacts With LRP1 Clusters II and IV Through a Site Close but Different From the Binding Site of Its C1r and C1s-Associated Proteases., PMID:33193398
The Pseudomonas aeruginosa HSP90-like protein HtpG regulates IL-8 expression through NF-κB/p38 MAPK and CYLD signaling triggered by TLR4 and CD91., PMID:32896641
Systemic delivery of peptides by the oral route: Formulation and medicinal chemistry approaches., PMID:32479930
Cell Stress Induced Stressome Release Including Damaged Membrane Vesicles and Extracellular HSP90 by Prostate Cancer Cells., PMID:32204513
Knockdown of Lrp1 in RAW264 cells inhibits osteoclast differentiation and osteoclast-osteoblast interactions in vitro., PMID:31964526
Octyl Gallate Induces Pancreatic Ductal Adenocarcinoma Cell Apoptosis and Suppresses Endothelial-Mesenchymal Transition-Promoted M2-Macrophages, HSP90α Secretion, and Tumor Growth., PMID:31905895
The Interplay Between Pattern Recognition Receptors and Autophagy in Inflammation., PMID:31728866
Roles of Extracellular HSPs as Biomarkers in Immune Surveillance and Immune Evasion., PMID:31533245
Deferoxamine therapy reduces brain hemin accumulation after intracerebral hemorrhage in piglets., PMID:31078524
CD91 on dendritic cells governs immunosurveillance of nascent, emerging tumors., PMID:30944251
CD11c+ MHCIIlo GM-CSF-bone marrow-derived dendritic cells act as antigen donor cells and as antigen presenting cells in neoepitope-elicited tumor immunity against a mouse fibrosarcoma., PMID:30030558
For research use only. Not for human or drug use.
