Catalog No.
DHH86501
Expression system
Mammalian Cells
Species reactivity
Human
Host species
Human
Isotype
IgG1-kappa
Clonality
Monoclonal
Target
hSEZ-6, SEZ6, Seizure protein 6 homolog, SEZ-6
Concentration
4.4 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Applications
Research Grade Biosimilar
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
ABBV-011
Soluble VCAM-1 may serve as a pharmacodynamic CSF marker to monitor BACE2 activity in non-human primates., PMID:40480341
Assessment of targets of antibody drug conjugates in SCLC., PMID:39748112
Detection of SEZ6, a therapeutic target, in medullary thyroid carcinoma., PMID:39324657
A Phase I First-in-Human Study of ABBV-011, a Seizure-Related Homolog Protein 6-Targeting Antibody-Drug Conjugate, in Patients with Small Cell Lung Cancer., PMID:39287821
Antibody-drug conjugates treatment of small cell lung cancer: advances in clinical research., PMID:39090431
Preclinical Characterization of Catabolic Pathways and Metabolism of ABBV-011, a Novel Calicheamicin-Based SEZ6-Targeting Antibody-Drug Conjugate., PMID:38050039
Unlocking New Horizons in Small-Cell Lung Cancer Treatment: The Onset of Antibody-Drug Conjugates., PMID:38001628
ABBV-011, A Novel, Calicheamicin-Based Antibody-Drug Conjugate, Targets SEZ6 to Eradicate Small Cell Lung Cancer Tumors., PMID:35642431
Click Chemistry-mediated Biotinylation Reveals a Function for the Protease BACE1 in Modulating the Neuronal Surface Glycoproteome., PMID:29716987
Seizure protein 6 and its homolog seizure 6-like protein are physiological substrates of BACE1 in neurons., PMID:27716410
Analysis of the Cerebrospinal Fluid Proteome in Alzheimer's Disease., PMID:26950848
The distribution of the seizure-related gene 6 (Sez-6) protein during postnatal development of the mouse forebrain suggests multiple functions for this protein: an analysis using a new antibody., PMID:21334315
Seizure-related gene 6 (Sez-6) in amacrine cells of the rodent retina and the consequence of gene deletion., PMID:19662096
Cloning and characterization of seizure-related gene, SEZ-6., PMID:7488116
For research use only. Not for human or drug use.
