Anti-TrpC6 Antibody (N490/24)

Catalog No.

RHJ83901

Host species

Mouse

Isotype

IgG2a, kappa

Clonality

Monoclonal

Target

TrpC6, TRP-6, Short transient receptor potential channel 6, Transient receptor protein 6, TRP6, TRPC6

Concentration

1 mg/ml

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Applications

IHC, WB

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Clone ID

N490/24

Cdc42 Activation in Anti-nephrin Antibody-Induced Nephropathy., PMID:40459930

TRPC6-targeted dexamethasone nanobubbles with ultrasound-guided theranostics for adriamycin-induced nephropathy., PMID:40448086

Distribution of TRPC1, TRPC3, and TRPC6 in the human thyroid., PMID:39740284

Evaluation of immunohistochemical TRPC3 and TRPC6 expression patterns in human endometriosis., PMID:39689787

TRPC6 is ubiquitously present in lymphatic tissues: A study using samples from body donors., PMID:39161881

Immunohistochemical expression of the cation channel TRPC6 in the submandibular and lacrimal gland and in salivary gland tumors., PMID:39098247

Distribution of TRPC3 and TRPC6 in the human exocrine and endocrine pancreas., PMID:38870712

TRPC3 Is Downregulated in Primary Hyperparathyroidism., PMID:38673977

Immunohistochemistry Reveals TRPC Channels in the Human Hearing Organ-A Novel CT-Guided Approach to the Cochlea., PMID:37298241

Familial systemic lupus erythematosus associated with a loss-of-function mutation in TRPC6., PMID:36944475

Neuroprotective Effects of Estrogen Through BDNF-Transient Receptor Potential Channels 6 Signaling Pathway in the Hippocampus in a Rat Model of Perimenopausal Depression., PMID:35875795

Evaluation of the presence of TRPC6 channels in human vessels: A pilot study using immunohistochemistry., PMID:35371476

RAGE and αVβ3-integrin are essential for suPAR signaling in podocytes., PMID:34166766

The ATP-gated P2X1 ion channel contributes to the severity of antibody-mediated Transfusion-Related Acute Lung Injury in mice., PMID:30914724

Potential Arrhythmogenic Role of TRPC Channels and Store-Operated Calcium Entry Mechanism in Mouse Ventricular Myocytes., PMID:30618800

Angiotensin II Type I Receptor Agonistic Autoantibody Induces Podocyte Injury via Activation of the TRPC6- Calcium/Calcineurin Pathway in Pre-Eclampsia., PMID:30380548

Endocardial TRPC-6 Channels Act as Atrial Mechanosensors and Load-Dependent Modulators of Endocardial/Myocardial Cross-Talk., PMID:30062171

Effects of nerve growth factor neutralization on TRP channel expression in laser-captured bladder afferent neurons in mice with spinal cord injury., PMID:29960052

Calcium-Sensing Receptor Stimulation in Cultured Glomerular Podocytes Induces TRPC6-Dependent Calcium Entry and RhoA Activation., PMID:29050010

Cardiovascular Effects of Renal Distal Tubule Deletion of the FGF Receptor 1 Gene., PMID:28993502

Genome-wide association study of cardiotoxicity in the NCCTG N9831 (Alliance) adjuvant trastuzumab trial., PMID:28763429

Differences in TRPC3 and TRPC6 channels assembly in mesenteric vascular smooth muscle cells in essential hypertension., PMID:27861908

Single nucleotide polymorphisms and genotypes of transient receptor potential ion channel and acetylcholine receptor genes from isolated B lymphocytes in myalgic encephalomyelitis/chronic fatigue syndrome patients., PMID:27834303

TRPV2 Channels Contribute to Stretch-Activated Cation Currents and Myogenic Constriction in Retinal Arterioles., PMID:27784066

Phage Immunoprecipitation Sequencing of Autoantigens in Autoimmune Retinopathy., PMID:27726466

TRPC6 channel activation promotes neonatal glomerular mesangial cell apoptosis via calcineurin/NFAT and FasL/Fas signaling pathways., PMID:27383564

TRPC6 May Protect Renal Ischemia-Reperfusion Injury Through Inhibiting Necroptosis of Renal Tubular Epithelial Cells., PMID:26913924

Using Phos-Tag in Western Blotting Analysis to Evaluate Protein Phosphorylation., PMID:26676139

TRPC6 channel translocation into phagosomal membrane augments phagosomal function., PMID:26604306

Relationship between calcium mobilization and platelet α- and δ-granule secretion. A role for TRPC6 in thrombin-evoked δ-granule exocytosis., PMID:26386308

Alpha1-Adrenergic Receptor Activation Stimulates Calcium Entry and Proliferation via TRPC6 Channels in Cultured Human Mesangial Cells., PMID:26202353

Focal segmental glomerulosclerosis: molecular genetics and targeted therapies., PMID:26156092

Receptor channel TRPC6 orchestrate the activation of human hepatic stellate cell under hypoxia condition., PMID:25845497

Functional expression of transient receptor potential channels in human endometrial stromal cells during the luteal phase of the menstrual cycle., PMID:25820697

Upregulation and Diverse Roles of TRPC3 and TRPC6 in Synaptic Reorganization of the Mossy Fiber Pathway in Temporal Lobe Epilepsy., PMID:25213992

Reducing endoglin activity limits calcineurin and TRPC-6 expression and improves survival in a mouse model of right ventricular pressure overload., PMID:25015075

IL-17A contributes to brain ischemia reperfusion injury through calpain-TRPC6 pathway in mice., PMID:24928352

Hyperforin attenuates microglia activation and inhibits p65-Ser276 NFκB phosphorylation in the rat piriform cortex following status epilepticus., PMID:24881563

Angiotensin II and canonical transient receptor potential-6 activation stimulate release of a signal transducer and activator of transcription 3-activating factor from mouse podocytes., PMID:24850910

Mechanotransduction channels of the trabecular meshwork., PMID:24215462

Expression and localization of TRPC proteins in rat ventricular myocytes at various developmental stages., PMID:24146259

Involvement of TRPC channels in lung cancer cell differentiation and the correlation analysis in human non-small cell lung cancer., PMID:23840757

STIM1 controls endothelial barrier function independently of Orai1 and Ca2+ entry., PMID:23512989

Knockout of the Trpc1 gene reveals that TRPC1 can promote recovery from anaphylaxis by negatively regulating mast cell TNF-α production., PMID:23489970

DAG-sensitive and Ca(2+) permeable TRPC6 channels are expressed in dentate granule cells and interneurons in the hippocampal formation., PMID:23193081

TRPC channels and their splice variants are essential for promoting human ovarian cancer cell proliferation and tumorigenesis., PMID:22920441

Brain-derived neurotrophic factor activation of CaM-kinase kinase via transient receptor potential canonical channels induces the translation and synaptic incorporation of GluA1-containing calcium-permeable AMPA receptors., PMID:22699894

Mild hypoxia-induced cardiomyocyte hypertrophy via up-regulation of HIF-1α-mediated TRPC signalling., PMID:22129453

Activation of TRPC cationic channels by mercurial compounds confers the cytotoxicity of mercury exposure., PMID:21984481

VEGF regulates TRPC6 channels in podocytes., PMID:21868397

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