Catalog No.
RHJ70703
Host species
Mouse
Isotype
IgG2a, kappa
Clonality
Monoclonal
Target
ADAM 22, MDC2, Metalloproteinase-disintegrin ADAM22-3, ADAM22, Metalloproteinase-like, disintegrin-like, and cysteine-rich protein 2, Disintegrin and metalloproteinase domain-containing protein 22
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Applications
IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
N57/2
Biallelic LGI1 and ADAM23 variants cause hippocampal epileptic encephalopathy via the LGI1-ADAM22/23 pathway., PMID:40455867
Novel risk loci in LGI1-antibody encephalitis: genome-wide association study discovery and validation cohorts., PMID:39454566
LGI1 Autoantibodies Enhance Synaptic Transmission by Presynaptic Kv1 Loss and Increased Action Potential Broadening., PMID:39141878
An Unusual Case of LGI1 (Leucine-Rich Glioma-Inactivated Protein 1) Limbic Encephalitis With Anti-acetylcholine Receptor and Anti-striational Autoantibodies., PMID:37927656
Anti-LGI4 Antibody Is a Novel Juxtaparanodal Autoantibody for Chronic Inflammatory Demyelinating Polyneuropathy., PMID:36631269
Distinctive binding properties of human monoclonal LGI1 autoantibodies determine pathogenic mechanisms., PMID:32437528
Human Cerebrospinal Fluid Monoclonal LGI1 Autoantibodies Increase Neuronal Excitability., PMID:31900946
Insights into the mechanisms of epilepsy from structural biology of LGI1-ADAM22., PMID:31432233
ADAM23 is a negative regulator of Kv1.1/Kv1.4 potassium currents., PMID:30965109
LGI1 antibodies alter Kv1.1 and AMPA receptors changing synaptic excitability, plasticity and memory., PMID:30346486
[Current Perspective on Voltage-gated Potassium Channel Complex Antibody Associated Diseases]., PMID:29632280
The importance of early immunotherapy in patients with faciobrachial dystonic seizures., PMID:29272336
[Voltage-Gated Potassium Channel-Complex Antibodies Associated Encephalopathy and Related Diseases]., PMID:27667487
[Autoimmune Associated Encephalitis and Dementia]., PMID:27056852
Autoantibodies to epilepsy-related LGI1 in limbic encephalitis neutralize LGI1-ADAM22 interaction and reduce synaptic AMPA receptors., PMID:24227725
LGI proteins in the nervous system., PMID:23713523
Quantitative and dynamic expression profile of premature and active forms of the regional ADAM proteins during chicken brain development., PMID:21786032
Investigation of LGI1 as the antigen in limbic encephalitis previously attributed to potassium channels: a case series., PMID:20580615
Biological characterization of ADAM22 variants reveals the importance of a disintegrin domain sequence in cell surface expression., PMID:20156119
For research use only. Not for human or drug use.
