Abundant non-inclusion α-synuclein pathology in Lewy body-negative LRRK2-mutant cases., PMID:40314782
Enhancing anti-CD3 mAb-mediated diabetes remission in autoimmune diabetes through regulation of dynamin-related protein 1(Drp1)-mediated mitochondrial dynamics in exhausted CD8+T-cell subpopulations., PMID:40165248
An Inducible Luminescent System to Explore Parkinson's Disease-Associated Genes., PMID:39273438
Biphenotypic Cells and α-Synuclein Accumulation in Enteric Neurons of Leucine-Rich Repeat Kinase 2 Knockout Mice., PMID:38849592
Structural insights into the GTP-driven monomerization and activation of a bacterial LRRK2 homolog using allosteric nanobodies., PMID:38666771
The Impact of 90 Parkinson's Disease-Risk Single Nucleotide Polymorphisms on Urinary Bis(monoacylglycerol)phosphate Levels in the Prodromal and PD Cohorts., PMID:38396963
Cellular and subcellular localization of Rab10 and phospho-T73 Rab10 in the mouse and human brain., PMID:38110990
LC3 Accelerated Brain-Lung Axis Abscopal Effects after Fractionated Whole-Brain Radiation by Promoting Motoneurons to Secrete Periostin., PMID:37796808
The Avidity of Autoreactive Alpha-Synuclein Antibodies in Leucine-Rich Repeat Kinase 2 Mutation Carriers Is Not Altered Compared to Healthy Controls or Patients with Parkinson's Disease., PMID:37759704
Alterations in the LRRK2-Rab pathway in urinary extracellular vesicles as Parkinson's disease and pharmacodynamic biomarkers., PMID:36750568
LRRK2 deficiency protects the heart against myocardial infarction injury in mice via the P53/HMGB1 pathway., PMID:36055602
Evaluation of Current Methods to Detect Cellular Leucine-Rich Repeat Kinase 2 (LRRK2) Kinase Activity., PMID:35599495
Nanobodies as allosteric modulators of Parkinson's disease-associated LRRK2., PMID:35217606
Pathological α-synuclein recruits LRRK2 expressing pro-inflammatory monocytes to the brain., PMID:35012605
Mild Chronic Colitis Triggers Parkinsonism in LRRK2 Mutant Mice Through Activating TNF-α Pathway., PMID:34918781
LRRK2 is required for CD38-mediated NAADP-Ca2+ signaling and the downstream activation of TFEB (transcription factor EB) in immune cells., PMID:34313548
Preclinical modeling of chronic inhibition of the Parkinson's disease associated kinase LRRK2 reveals altered function of the endolysosomal system in vivo., PMID:33741046
Analysis of α-synuclein levels related to LRRK2 kinase activity: from substantia nigra to urine of patients with Parkinson's disease., PMID:33717414
Deciphering the LRRK code: LRRK1 and LRRK2 phosphorylate distinct Rab proteins and are regulated by diverse mechanisms., PMID:33459343
Divergent Effects of G2019S and R1441C LRRK2 Mutations on LRRK2 and Rab10 Phosphorylations in Mouse Tissues., PMID:33105882
Allosteric inhibition of LRRK2, where are we now., PMID:33079169
The Michael J. Fox Foundation's Strategies for Accelerating Translation of LRRK2 into Therapies for Parkinson Disease., PMID:32796584
Parkinson's disease: etiopathogenesis and treatment., PMID:32576618
Quantitative Measurements of LRRK2 in Human Cerebrospinal Fluid Demonstrates Increased Levels in G2019S Patients., PMID:32523511
Human Peripheral Blood Neutrophil Isolation for Interrogating the Parkinson's Associated LRRK2 Kinase Pathway by Assessing Rab10 Phosphorylation., PMID:32250352
Allosteric modulation of the GTPase activity of a bacterial LRRK2 homolog by conformation-specific Nanobodies., PMID:32167135
Alzheimer's disease tau is a prominent pathology in LRRK2 Parkinson's disease., PMID:31733655
Reduced serum immunoglobulin G concentrations in multiple sclerosis: prevalence and association with disease-modifying therapy and disease course., PMID:31632461
Elucidating Critical Proteinopathic Mechanisms and Potential Drug Targets in Neurodegeneration., PMID:31584139
Discovery of a class of highly potent Janus Kinase 1/2 (JAK1/2) inhibitors demonstrating effective cell-based blockade of IL-13 signaling., PMID:30981576
Emerging views of mitophagy in immunity and autoimmune diseases., PMID:30951392
LRRK2 is involved in the pathogenesis of system lupus erythematosus through promoting pathogenic antibody production., PMID:30670047
Rab32 interacts with SNX6 and affects retromer-dependent Golgi trafficking., PMID:30640902
Designing antibodies against LRRK2-targeted tau epitopes., PMID:30261006
The Parkinson's disease VPS35[D620N] mutation enhances LRRK2-mediated Rab protein phosphorylation in mouse and human., PMID:29743203
Rab10 Phosphorylation is a Prominent Pathological Feature in Alzheimer's Disease., PMID:29562525
P62/SQSTM1 is a novel leucine-rich repeat kinase 2 (LRRK2) substrate that enhances neuronal toxicity., PMID:29519959
Back to the future: new target-validated Rab antibodies for evaluating LRRK2 signalling in cell biology and Parkinson's disease., PMID:29305429
Rab10 Phosphorylation Detection by LRRK2 Activity Using SDS-PAGE with a Phosphate-binding Tag., PMID:29286425
Genetic polymorphism in ATG16L1 gene is associated with adalimumab use in inflammatory bowel disease., PMID:29228965
Parkinson's disease-associated mutant LRRK2 phosphorylates Rab7L1 and modifies trans-Golgi morphology., PMID:29223392
Development of phospho-specific Rab protein antibodies to monitor in vivo activity of the LRRK2 Parkinson's disease kinase., PMID:29127256
Interrogating Parkinson's disease LRRK2 kinase pathway activity by assessing Rab10 phosphorylation in human neutrophils., PMID:29127255
PLA2G6 accumulates in Lewy bodies in PARK14 and idiopathic Parkinson's disease., PMID:28213071
LRRK2: An Emerging New Molecule in the Enteric Neuronal System That Quantitatively Regulates Neuronal Peptides and IgA in the Gut., PMID:28168579
Phosphorylation of p53 by LRRK2 induces microglial tumor necrosis factor α-mediated neurotoxicity., PMID:27914807
Leucine-rich repeat kinase 2 (LRRK2) regulates α-synuclein clearance in microglia., PMID:27903237
'Up with the LRRK': a phosphorylated Rab10 assay for evaluation of LRRK2 activity and inhibitor engagement., PMID:27621483
Leucine-rich repeat kinase 2 is a regulator of B cell function, affecting homeostasis, BCR signaling, IgA production, and TI antigen responses., PMID:26943952
Down-regulation of B cell-related genes in peripheral blood leukocytes of Parkinson's disease patients with and without GBA mutations., PMID:26410072
For research use only. Not for human or drug use.
