Catalog No.
PHF99301
Species reactivity
Human, Mouse, Rat
Host species
Rabbit
Isotype
IgG
Clonality
Polyclonal
Immunogen
E. coli - derived recombinant Human PTH1R (Ala28-Gly188).
Tested applications
ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000
Target
PTH/PTHr receptor,Parathyroid hormone 1 receptor,PTHR1,PTHR,PTH1 receptor,PTH/PTHrP type I receptor,PTH1R,Parathyroid hormone/parathyroid hormone-related peptide receptor
Purification
Purified by antigen affinity column.
Accession
Q03431
Applications
ELISA, IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Receptor activity-modifying protein modulation of parathyroid hormone-1 receptor function and signaling., PMID:39376604
Romosozumab versus parathyroid hormone receptor agonists: which osteoanabolic to choose and when?, PMID:38938063
Highly biased agonism for GPCR ligands via nanobody tethering., PMID:38824166
The pathophysiology of hypophosphatemia., PMID:38087658
Targeting strategies for bone diseases: signaling pathways and clinical studies., PMID:37198232
Modulation of PTH1R signaling by an extracellular binding antibody., PMID:35953107
High sodium reduced the expression of PTH1R and Klotho by inhibiting 1,25(OH)2D3 synthesis in cultured proximal tubule epithelial cells., PMID:35928745
Parathyroid hormone-related peptide and parathyroid hormone-related peptide receptor type 1 in locally advanced laryngeal cancer as prognostic indicators of relapse and survival., PMID:35761298
Functional Properties of Two Distinct PTH1R Mutants Associated With Either Skeletal Defects or Pseudohypoparathyroidism., PMID:35720667
PTHrP induces STAT5 activation, secretory differentiation and accelerates mammary tumor development., PMID:35440032
Parathyroid Hormone Resistance and Autoantibodies to the PTH1 Receptor., PMID:34788508
Runx1 up-regulates chondrocyte to osteoblast lineage commitment and promotes bone formation by enhancing both chondrogenesis and osteogenesis., PMID:32391876
Modulation of PTH1R signaling by an ECD binding antibody results in inhibition of β-arrestin 2 coupling., PMID:31594997
α-PD-1 therapy elevates Treg/Th balance and increases tumor cell pSmad3 that are both targeted by α-TGFβ antibody to promote durable rejection and immunity in squamous cell carcinomas., PMID:30832732
MMP14 is a novel target of PTH signaling in osteocytes that controls resorption by regulating soluble RANKL production., PMID:29401593
Production and evaluation of parathyroid hormone receptor1 ligands with intrinsic or assembled peroxidase domains., PMID:29026164
Matrix metalloproteinase processing of PTHrP yields a selective regulator of osteogenesis, PTHrP1-17., PMID:28368420
A tagged parathyroid hormone derivative as a carrier of antibody cargoes transported by the G protein coupled PTH1 receptor., PMID:25128082
Knockdown of PTHR1 in osteosarcoma cells decreases invasion and growth and increases tumor differentiation in vivo., PMID:25043296
Development and validation of a novel cell-based assay for potency determination of human parathyroid hormone (PTH)., PMID:24996007
Amphiregulin-EGFR signaling mediates the migration of bone marrow mesenchymal progenitors toward PTH-stimulated osteoblasts and osteocytes., PMID:23300521
Osteogenesis and expression of the bone marrow niche in endothelial cell-depleted HipOPs., PMID:23161750
Fragmented adipose tissue transplanted to craniofacial deformities induces bone repair associated with immunoexpression of adiponectin and parathyroid hormone 1-receptor., PMID:23145915
Fluorescent ligand-directed co-localization of the parathyroid hormone 1 receptor with the brush-border scaffold complex of the proximal tubule reveals hormone-dependent changes in ezrin immunoreactivity consistent with inactivation., PMID:23036889
Role of parathyroid hormone-related protein in the pro-inflammatory and pro-fibrogenic response associated with acute pancreatitis., PMID:22280800
PTHrP increases RANKL expression by stromal cells from giant cell tumor of bone., PMID:22102368
PTHrP regulates angiogenesis and bone resorption via VEGF expression., PMID:20683010
Parathyroid hormone-related protein induces hypertrophy in podocytes via TGF-beta(1) and p27(Kip1): implications for diabetic nephropathy., PMID:20200004
Immunohistochemical identification of the PTHR1 parathyroid hormone receptor in normal and neoplastic human tissues., PMID:20156969
Parathyroid hormone-related peptide (PTHrP), parathyroid hormone/parathyroid hormone-related peptide receptor 1 (PTHR1), and MSX1 protein are expressed in central and peripheral giant cell granulomas of the jaws., PMID:20060342
Generation of human PTH1R construct with FLAG epitope located internally: comparison of two-fragment assembly by using PCR overlap extension or ligase., PMID:19721821
Endogenous parathyroid hormone-related protein regulates the expression of PTH type 1 receptor and proliferation of vascular smooth muscle cells., PMID:19574446
Structural basis for antibody discrimination between two hormones that recognize the parathyroid hormone receptor., PMID:19346515
Crystallization of the receptor-binding domain of parathyroid hormone-related protein in complex with a neutralizing monoclonal antibody Fab fragment., PMID:19342773
Ischemic injury activates PTHrP and PTH1R expression in human ventricular cardiomyocytes., PMID:19190955
Evolution of PTH assays., PMID:17117287
Influence of the parathyroid glands on bone metabolism., PMID:16884395
Pathogenic role of connective tissue growth factor (CTGF/CCN2) in osteolytic metastasis of breast cancer., PMID:16813525
Type 1 parathyroid hormone receptor (PTH1R) nuclear trafficking: association of PTH1R with importin alpha1 and beta., PMID:16574786
Antitumor effect of parathyroid hormone-related protein neutralizing antibody in human renal cell carcinoma in vitro and in vivo., PMID:16081513
[Parathyroid hormone values obtained with immunometric assays depend on the amino-terminal antibody specificity]., PMID:15761516
Regulation of Indian hedgehog mRNA levels in chondrocytic cells by ERK1/2 and p38 mitogen-activated protein kinases., PMID:15389630
Expression of parathyroid hormone-related peptide (PthrP) and its receptor (PTH1R) during the histogenesis of cartilage and bone in the chicken mandibular process., PMID:12220122
Parathyroid hormone-related protein as a potential target of therapy for cancer-associated morbidity., PMID:10898333
For research use only. Not for human or drug use.
