Catalog No.
RHG58401
Species reactivity
Human, Mouse, Rat
Host species
Mouse
Isotype
IgG2a, kappa
Clonality
Monoclonal
Target
CAMKG, CAMK-II, CAMK, CAMK2G, CaM kinase II subunit gamma, CaMK-II subunit gamma, Calcium/calmodulin-dependent protein kinase type II subunit gamma
Concentration
3.31 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
Q63633
Applications
ICC, IF, IHC, WB
Form
Liquid
Storage buffer
100 mM Pro-Ac, 20 mM Arg, pH 5.0
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
N1/12
Maternal immune activation alters the GABAergic system in the prefrontal cortex of female rat offspring: Role of interleukin-6., PMID:39884421
EA participates in pain transition through regulating KCC2 expression by BDNF-TrkB in the spinal cord dorsal horn of male rats., PMID:36875547
Targeting the Cation-Chloride Co-Transporter NKCC1 to Re-Establish GABAergic Inhibition and an Appropriate Excitatory/Inhibitory Balance in Selective Neuronal Circuits: A Novel Approach for the Treatment of Alzheimer's Disease., PMID:35741668
Body Weight-Supported Treadmill Training Ameliorates Motoneuronal Hyperexcitability by Increasing GAD-65/67 and KCC2 Expression via TrkB Signaling in Rats with Incomplete Spinal Cord Injury., PMID:35320460
Involvement of the BDNF-TrkB-KCC2 pathway in neuropathic pain after brachial plexus avulsion., PMID:35106976
A Female-Specific Role for Calcitonin Gene-Related Peptide (CGRP) in Rodent Pain Models., PMID:35058371
NKCC1, an Elusive Molecular Target in Brain Development: Making Sense of the Existing Data., PMID:33291778
Staurosporine and NEM mainly impair WNK-SPAK/OSR1 mediated phosphorylation of KCC2 and NKCC1., PMID:32413057
Novel Treatment Targets Based on Insights in the Etiology of Depression: Role of IL-6 Trans-Signaling and Stress-Induced Elevation of Glutamate and ATP., PMID:31362361
Potassium channels in omnipause neurons., PMID:31325972
Sortilin gates neurotensin and BDNF signaling to control peripheral neuropathic pain., PMID:31223654
Implications of the N-terminal heterogeneity for the neuronal K-Cl cotransporter KCC2 function., PMID:28888841
Depolarizing γ-aminobutyric acid contributes to glutamatergic network rewiring in epilepsy., PMID:28074534
Pro-Brain-Derived Neurotrophic Factor (proBDNF)-Mediated p75NTR Activation Promotes Depolarizing Actions of GABA and Increases Susceptibility to Epileptic Seizures., PMID:27913431
Complete spinal cord injury (SCI) transforms how brain derived neurotrophic factor (BDNF) affects nociceptive sensitization., PMID:27818188
BDNF Induced by Treadmill Training Contributes to the Suppression of Spasticity and Allodynia After Spinal Cord Injury via Upregulation of KCC2., PMID:25527489
Distribution of neuronal KCC2a and KCC2b isoforms in mouse CNS., PMID:24639001
Isolating specific cell and tissue compartments from 3D images for quantitative regional distribution analysis using novel computer algorithms., PMID:24487018
Carbon nanotubes in neuroregeneration and repair., PMID:23856411
K+-Cl- cotransporter-2 KCC2 in chicken cardiomyocytes., PMID:23034386
KCC2a expression in a human fetal lens epithelial cell line., PMID:22415099
Mesenchymal stem cells enhance GABAergic transmission in co-cultured hippocampal neurons., PMID:22388097
Effect of the calcineurin inhibitor FK506 on K+-Cl- cotransporter 2 expression in the mouse hippocampus after kainic acid-induced status epilepticus., PMID:22160488
A prolonged experimental febrile seizure results in motor map reorganization in adulthood., PMID:22044736
Differential distribution of KCC2 along the axo-somato-dendritic axis of hippocampal principal cells., PMID:20880357
Ontogeny of Cl- homeostasis in mouse hypoglossal nucleus., PMID:20217315
In the adult hippocampus, chronic nerve growth factor deprivation shifts GABAergic signaling from the hyperpolarizing to the depolarizing direction., PMID:20089897
Coexpression and heteromerization of two neuronal K-Cl cotransporter isoforms in neonatal brain., PMID:19307176
Spatial and temporal distribution patterns of Na-K-2Cl cotransporter in adult and developing mouse retinas., PMID:18442435
Heterogeneous expression of gamma-aminobutyric acid and gamma-aminobutyric acid-associated receptors and transporters in the rat suprachiasmatic nucleus., PMID:18067149
Multiple functions of cation-chloride cotransporters in the fish retina., PMID:17900379
Characterization of an extracellular epitope antibody to the neuronal K-Cl cotransporter, KCC2., PMID:17581210
Dendritic compartmentalization of chloride cotransporters underlies directional responses of starburst amacrine cells in retina., PMID:17124178
Developmental localization of potassium chloride co-transporter 2 in granule cells of the early postnatal mouse cerebellum with special reference to the synapse formation., PMID:17008020
KCC isoforms in a human lens epithelial cell line (B3) and lens tissue extracts., PMID:16949074
Sex- and cell-type-specific patterns of GABAA receptor and estradiol-mediated signaling in the immature rat substantia nigra., PMID:16706849
Roles for KCC transporters in the maintenance of lens transparency., PMID:16431967
Cortical neurons lacking KCC2 expression show impaired regulation of intracellular chloride., PMID:15469961
Developmental up-regulation of KCC2 in the absence of GABAergic and glutamatergic transmission., PMID:14686894
Heterogeneous expression of the potassium-chloride cotransporter KCC2 in gonadotropin-releasing hormone neurons of the adult mouse., PMID:12810559
Developmental regulation of the neuronal-specific isoform of K-Cl cotransporter KCC2 in postnatal rat brains., PMID:10380077
The neuron-specific K-Cl cotransporter, KCC2. Antibody development and initial characterization of the protein., PMID:10212246
For research use only. Not for human or drug use.
