Anti-IRF8 Polyclonal Antibody

Catalog No.

PHF94801

Species reactivity

Human, Mouse, Rat

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human IRF8 (Gly128-Val426).

Tested applications

ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000

Target

Interferon regulatory factor 8,H-ICSBP,IRF-8,ICSBP1,ICSBP,IRF8,Interferon consensus sequence-binding protein

Purification

Purified by antigen affinity column.

Accession

Q02556

Applications

ELISA, IHC, WB

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Targeting the poliovirus receptor to activate T cells and induce myeloid-derived suppressor cells to differentiate to pro-inflammatory macrophages via the IFN-γ-p-STAT1-IRF8 axis in cancer therapy., PMID:40229462

A novel dominant-negative variant of IRF8 in a mother and son: Clinical, phenotypic and biological characteristics., PMID:40072380

Transcriptional function of E2A, Ebf1, Pax5, Ikaros and Aiolos analyzed by in vivo acute protein degradation in early B cell development., PMID:39179932

Human inborn errors of immunity associated with IRF4., PMID:37809068

Case report: Clinicopathological and molecular characteristics of pediatric-type follicular lymphoma., PMID:37539011

Short-term immune-checkpoint inhibition partially rescues perturbed bone marrow hematopoiesis in mismatch-repair deficient tumors., PMID:37396958

Genome-wide association analyses define pathogenic signaling pathways and prioritize drug targets for IgA nephropathy., PMID:37337107

Tumor-derived prostaglandin E2 programs cDC1 dysfunction to impair intratumoral orchestration of anti-cancer T cell responses., PMID:37315536

Immunization with a novel mRNA vaccine, TGGT1_216200 mRNA-LNP, prolongs survival time in BALB/c mice against acute toxoplasmosis., PMID:37122740

A novel Toxoplasma gondii TGGT1_316290 mRNA-LNP vaccine elicits protective immune response against toxoplasmosis in mice., PMID:37025641

Association of CD206 Protein Expression with Immune Infiltration and Prognosis in Patients with Triple-Negative Breast Cancer., PMID:36230752

IRF8 regulates efficacy of therapeutic anti-CD20 monoclonal antibodies., PMID:36030374

Sublytic C5b-9 Induces CCL3/4 Production and Macrophage Accumulation in Thy-1N Rats via PKC-α/p65/IRF-8 Axis., PMID:35637950

Molecular mechanisms controlling age-associated B cells in autoimmunity., PMID:35102602

IRF8 is a Reliable Monoblast Marker for Acute Monocytic Leukemias., PMID:34172624

A simplified method for separating renal MPCs using SLAMF9., PMID:34092043

Minimalistic In Vitro Culture to Drive Human Naive B Cell Differentiation into Antibody-Secreting Cells., PMID:34066151

The diversity of the plasmablast signature across species and experimental conditions: A meta-analysis., PMID:34041745

Point Mutation Specific Antibodies in B-Cell and T-Cell Lymphomas and Leukemias: Targeting IDH2, KRAS, BRAF and Other Biomarkers RHOA, IRF8, MYD88, ID3, NRAS, SF3B1 and EZH2., PMID:33801781

High IRF8 expression correlates with CD8 T cell infiltration and is a predictive biomarker of therapy response in ER-negative breast cancer., PMID:33766090

Reduced Expression of Autophagy Markers and Expansion of Myeloid-Derived Suppressor Cells Correlate With Poor T Cell Response in Severe COVID-19 Patients., PMID:33692788

Abnormal thymic B cell activation and impaired T cell differentiation in pristane-induced lupus mice., PMID:33428991

VISTA Re-programs Macrophage Biology Through the Combined Regulation of Tolerance and Anti-inflammatory Pathways., PMID:33178206

Mechanism of Follicular Helper T Cell Differentiation Regulated by Transcription Factors., PMID:32766317

TBLR1 and CREBBP as potential novel prognostic immunohistochemical biomarkers in diffuse large B-cell lymphoma., PMID:32546039

Generation and characterization of the Eµ-Irf8 mouse model., PMID:32535543

Multi-parameter immune profiling of peripheral blood mononuclear cells by multiplexed single-cell mass cytometry in patients with early multiple sclerosis., PMID:31857644

Genome-Wide Analysis Identifies Two Susceptibility Loci for Positive Thyroid Peroxidase and Thyroglobulin Antibodies., PMID:31794020

Blockade of myeloid-derived suppressor cell function by valproic acid enhanced anti-PD-L1 tumor immunotherapy., PMID:31785814

Leukocyte-specific siRNA delivery revealing IRF8 as a potential anti-inflammatory target., PMID:31634546

Genetic contributors and soluble mediators in prediction of autoimmune comorbidity., PMID:31444033

Persistent stimulation with Mycobacterium tuberculosis antigen impairs the proliferation and transcriptional program of hematopoietic cells in bone marrow., PMID:31082645

Transcription factors IRF8 and PU.1 are required for follicular B cell development and BCL6-driven germinal center responses., PMID:31000603

GRA24-Based DNA Vaccine Prolongs Survival in Mice Challenged With a Virulent Toxoplasma gondii Strain., PMID:30894865

Identification of New Potential Therapies for Colitis Amelioration Using an Appendicitis-Appendectomy Model., PMID:30329049

The Expression of Interferon Regulatory Factor 8 in Human Periapical Lesions., PMID:29935870

Altered expression of transcription factors IRF4 and IRF8 in peripheral blood B cells is associated with clinical severity and circulating plasma cells frequency in patients with myasthenia gravis., PMID:29569949

CD103+CD11b+ mucosal classical dendritic cells initiate long-term switched antibody responses to flagellin., PMID:29346347

TIM-3 Regulates CD103+ Dendritic Cell Function and Response to Chemotherapy in Breast Cancer., PMID:29316433

IRF-1 SNPs influence the risk for childhood allergic asthma: A critical role for pro-inflammatory immune regulation., PMID:29047170

Antigen cross-presentation and T-cell cross-priming in cancer immunology and immunotherapy., PMID:28945841

An aberrant NOTCH2-BCR signaling axis in B cells from patients with chronic GVHD., PMID:28851699

Maintenance of the marginal-zone B cell compartment specifically requires the RNA-binding protein ZFP36L1., PMID:28394372

TLR9 mediated regulatory B10 cell amplification following sub-total body irradiation: Implications in attenuating EAE., PMID:28110075

Total cellular protein presence of the transcription factor IRF8 does not necessarily correlate with its nuclear presence., PMID:27582125

Systemic lupus erythematosus: still a challenge for physicians., PMID:27307107

The Expression of BAFF Is Controlled by IRF Transcription Factors., PMID:26590315

Regulation of bifurcating B cell trajectories by mutual antagonism between transcription factors IRF4 and IRF8., PMID:26437243

Transcription factor IRF8 controls Th1-like regulatory T-cell function., PMID:26166768

Association of IRF8 gene polymorphisms with autoimmune thyroid disease., PMID:25989711

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