Catalog No.
RHG37102
Host species
Mouse
Isotype
IgG2a, kappa
Clonality
Monoclonal
Target
TIAM-1, TIAM1, T-lymphoma invasion and metastasis-inducing protein 1
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Applications
IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
L130/119
CTLA-4 blockade and interferon-α induce proinflammatory transcriptional changes in the tumor immune landscape that correlate with pathologic response in melanoma., PMID:33428680
The Fibroblast TIAM2 Promotes Lung Cancer Cell Invasion and Metastasis., PMID:31205545
LFA-1 integrin antibodies inhibit leukocyte α4β1-mediated adhesion by intracellular signaling., PMID:27443292
ERK2-mediated phosphorylation of Par3 regulates neuronal polarization., PMID:23946386
Uptake of advanced glycation end products by proximal tubule epithelial cells via macropinocytosis., PMID:23747564
VE-cadherin trans-interactions modulate Rac activation and enhancement of lung endothelial barrier by iloprost., PMID:22213015
Tiam1, overexpressed in most malignancies, is a novel tumor biomarker., PMID:21971868
Inactivation of Rac1 reduces Trastuzumab resistance in PTEN deficient and insulin-like growth factor I receptor overexpressing human breast cancer SKBR3 cells., PMID:21943825
CADM1 interacts with Tiam1 and promotes invasive phenotype of human T-cell leukemia virus type I-transformed cells and adult T-cell leukemia cells., PMID:20215110
ANP attenuates inflammatory signaling and Rho pathway of lung endothelial permeability induced by LPS and TNFalpha., PMID:19931545
Regulation of cross-linked actin network (CLAN) formation in human trabecular meshwork (HTM) cells by convergence of distinct beta1 and beta3 integrin pathways., PMID:19643963
Sonic hedgehog-responsive genes in the fetal prostate., PMID:19095649
The expression and prognostic value of the guanine nucleotide exchange factors (GEFs) Trio, Vav1 and TIAM-1 in human breast cancer., PMID:18925966
The role of T-lymphoma invasion and metastasis inducing protein 1 in early pregnancy in mice., PMID:18765636
SRC-dependent signalling regulates actin ruffle formation induced by glycerophosphoinositol 4-phosphate., PMID:18722484
CD44 regulates hepatocyte growth factor-mediated vascular integrity. Role of c-Met, Tiam1/Rac1, dynamin 2, and cortactin., PMID:17702746
HGF attenuates thrombin-induced endothelial permeability by Tiam1-mediated activation of the Rac pathway and by Tiam1/Rac-dependent inhibition of the Rho pathway., PMID:17428964
Interaction between Tiam1 and the Arp2/3 complex links activation of Rac to actin polymerization., PMID:16599904
Ras activation of a Rac1 exchange factor, Tiam1, mediates neurotrophin-3-induced Schwann cell migration., PMID:16203995
Regulation of p70 S6 kinase by complex formation between the Rac guanine nucleotide exchange factor (Rac-GEF) Tiam1 and the scaffold spinophilin., PMID:12531897
Rac activation induces NADPH oxidase activity in transgenic COSphox cells, and the level of superoxide production is exchange factor-dependent., PMID:11896053
Tiam1 overexpression potentiates heregulin-induced lymphoid enhancer factor-1/beta -catenin nuclear signaling in breast cancer cells by modulating the intercellular stability., PMID:11328805
Evidence for the involvement of Tiam1 in axon formation., PMID:11264310
For research use only. Not for human or drug use.
