Catalog No.
RHG32003
Host species
Mouse
Isotype
IgG2a, kappa
Clonality
Monoclonal
Target
N-methyl D-aspartate receptor subtype 2A, NMDAR2A, Glutamate [NMDA] receptor subunit epsilon-1, hNR2A, NR2A, Glutamate receptor ionotropic, NMDA 2A, GRIN2A, GluN2A
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Applications
IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
N327A/4
Input-Specific Localization of NMDA Receptor GluN2 Subunits in Thalamocortical Neurons., PMID:40123534
Assembly and architecture of endogenous NMDA receptors in adult cerebral cortex and hippocampus., PMID:39855198
Input-specific localization of NMDA receptor GluN2 subunits in thalamocortical neurons., PMID:39229083
Novel mechanisms of Anshen Dingzhi prescription against PTSD: Inhibiting DCC to modulate synaptic function and inflammatory responses., PMID:38848974
Subunit-Dependent Surface Mobility and Localization of NMDA Receptors in Hippocampal Neurons Measured Using Nanobody Probes., PMID:37286354
NMDA-receptor-Fc-fusion constructs neutralize anti-NMDA receptor antibodies., PMID:36866449
Expression of the ionotropic glutamate receptors on neuronostatin neurons in the periventricular nucleus of the hypothalamus., PMID:33330967
Immunotherapy in GRIN2A-negative Landau-Kleffner Syndrome., PMID:32441907
Lupus autoantibodies act as positive allosteric modulators at GluN2A-containing NMDA receptors and impair spatial memory., PMID:32179753
Alpha-synuclein targets GluN2A NMDA receptor subunit causing striatal synaptic dysfunction and visuospatial memory alteration., PMID:30927362
Immuno-Pharmacological Characterization of Presynaptic GluN3A-Containing NMDA Autoreceptors: Relevance to Anti-NMDA Receptor Autoimmune Diseases., PMID:30734226
HIV gp120-induced neuroinflammation potentiates NMDA receptors to overcome basal suppression of inhibitory synapses by p38 MAPK., PMID:30520043
Clinical significance of anti-DNA/N-methyl-D-aspartate receptor 2 antibodies in de novo and post-steroid cases with neuropsychiatric systemic lupus erythematosus., PMID:30358102
Identification of C-Terminal Binding Protein 1 as a Novel NMDA Receptor Interactor., PMID:30284099
NMDA Receptor Autoantibodies in Autoimmune Encephalitis Cause a Subunit-Specific Nanoscale Redistribution of NMDA Receptors., PMID:29949761
Antibodies and the brain: anti-N-methyl-D-aspartate receptor antibody and the clinical effects in patients with systemic lupus erythematosus., PMID:29474315
Understanding the Antibody Repertoire in Neuropsychiatric Systemic Lupus Erythematosus and Neuromyelitis Optica Spectrum Disorder: Do They Share Common Targets?, PMID:29073350
Hyaluronic acid based extracellular matrix regulates surface expression of GluN2B containing NMDA receptors., PMID:28887453
Cryo-EM structures of the triheteromeric NMDA receptor and its allosteric modulation., PMID:28232581
Dysfunction of the blood-cerebrospinal fluid-barrier and N-methyl-D-aspartate glutamate receptor antibodies in dementias., PMID:28176002
Immunohistochemical localization of ionotropic glutamate receptors in the rat red nucleus., PMID:28027456
Anti-NMDA receptor autoantibodies and associated neurobehavioral pathology in mice are dependent on age of first exposure to Toxoplasma gondii., PMID:26969530
Immunity and Inflammation in Epilepsy., PMID:26684336
Integrative neuroscience approach to neuropsychiatric lupus., PMID:26467973
Selective Impairment of Spatial Cognition Caused by Autoantibodies to the N-Methyl-D-Aspartate Receptor., PMID:26286205
A negative feedback loop controls NMDA receptor function in cortical interneurons via neuregulin 2/ErbB4 signalling., PMID:26027736
Anti-NR2A/B Antibodies and Other Major Molecular Mechanisms in the Pathogenesis of Cognitive Dysfunction in Systemic Lupus Erythematosus., PMID:25955648
Short-term sleep deprivation impairs spatial working memory and modulates expression levels of ionotropic glutamate receptor subunits in hippocampus., PMID:25732956
Hippocampal receptor complexes paralleling LTP reinforcement in the spatial memory holeboard test in the rat., PMID:25639541
Interferon-α induces neurotoxicity through activation of the type I receptor and the GluN2A subunit of the NMDA receptor., PMID:25517826
Differential alterations of neocortical GluN receptor subunits in patients with mixed subcortical ischemic vascular dementia and Alzheimer's disease., PMID:25261450
Clustering of surface NMDA receptors is mainly mediated by the C-terminus of GluN2A in cultured rat hippocampal neurons., PMID:25015063
Crucial role of calbindin-D28k in the pathogenesis of Alzheimer's disease mouse model., PMID:24853300
Surface dynamics of GluN2B-NMDA receptors controls plasticity of maturing glutamate synapses., PMID:24591565
NMDA reduces Tau phosphorylation in rat hippocampal slices by targeting NR2A receptors, GSK3β, and PKC activities., PMID:24349798
Pathological reorganization of NMDA receptors subunits and postsynaptic protein PSD-95 distribution in Alzheimer's disease., PMID:24156266
α-Amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) and N-methyl-D-aspartate (NMDA) receptors adopt different subunit arrangements., PMID:23760273
[Antibodies to the glutamate receptor]., PMID:23568982
Visualization of structural changes accompanying activation of N-methyl-D-aspartate (NMDA) receptors using fast-scan atomic force microscopy imaging., PMID:23223336
Disrupted surface cross-talk between NMDA and Ephrin-B2 receptors in anti-NMDA encephalitis., PMID:22544902
Pilot study of iPS-derived neural cells to examine biologic effects of alcohol on human neurons in vitro., PMID:22486492
Mass spectrometrical identification of hippocampal NMDA receptor subunits NR1, NR2A-D and five novel phosphorylation sites on NR2A and NR2B., PMID:22335236
Association of GRIN1 and GRIN2A-D with schizophrenia and genetic interaction with maternal herpes simplex virus-2 infection affecting disease risk., PMID:21919190
Antibody-mediated targeted gene transfer of helper virus-free HSV-1 vectors to rat neocortical neurons that contain either NMDA receptor 2B or 2A subunits., PMID:21885042
Immunolocalization of NR1, NR2A, and PSD-95 in rat hippocampal subregions during postnatal development., PMID:21719075
[Roles and expressions of the NMDA receptor subunits (NR2A and NR2B) in visual cortex area of kittens with the normal visual development and anisometropic amblyopia]., PMID:21604481
Role of endoplasmic reticulum stress in the amygdaloid kindling model of rats., PMID:21604154
NMDA-complexes linked to spatial memory performance in the Barnes maze in CD1 mice., PMID:21377497
Immunogold electron microscopic evidence of differential regulation of GluN1, GluN2A, and GluN2B, NMDA-type glutamate receptor subunits in rat hippocampal CA1 synapses during benzodiazepine withdrawal., PMID:20853509
A 9-year-old boy in a confused, sleepy state., PMID:19968190
For research use only. Not for human or drug use.
