Anti-SUR1 Antibody (N289/16)

Catalog No.

RHG20501

Host species

Mouse

Isotype

IgG2a, kappa

Clonality

Monoclonal

Target

SUR, SUR1, HRINS, ABCC8, ATP-binding cassette sub-family C member 8, Sulfonylurea receptor 1

Concentration

1 mg/ml

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Applications

IHC, WB

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Clone ID

N289/16

Optimization of a Glucagon-Like Peptide 1 Receptor Antagonist Antibody for Treatment of Hyperinsulinism., PMID:37358194

ABCC8-related maturity-onset diabetes of the young: Clinical features and genetic analysis of one case., PMID:35757975

Pharmacological Modulation and (Patho)Physiological Roles of TRPM4 Channel-Part 1: Modulation of TRPM4., PMID:35056138

KATP and TRPM2-like channels couple metabolic status to resting membrane potential of octopus neurons in the mouse ventral cochlear nucleus., PMID:33581312

Endothelial Cell-Derived Triosephosphate Isomerase Attenuates Insulin Secretion From Pancreatic Beta Cells of Male Rats., PMID:33341896

HIV-1 Vpr-Induced Proinflammatory Response and Apoptosis Are Mediated through the Sur1-Trpm4 Channel in Astrocytes., PMID:33293383

Localization of ATP-sensitive K+ channel subunits in rat liver., PMID:31938690

SUR1-TRPM4 channels, not KATP, mediate brain swelling following cerebral ischemia., PMID:31899311

A unique allosteric insulin receptor monoclonal antibody that prevents hypoglycemia in the SUR-1-/- mouse model of KATP hyperinsulinism., PMID:29589989

Modulation of Excitability of Stellate Neurons in the Ventral Cochlear Nucleus of Mice by ATP-Sensitive Potassium Channels., PMID:29379989

Direct versus indirect actions of ghrelin on hypothalamic NPY neurons., PMID:28877214

Targeted next-generation sequencing reveals MODY in up to 6.5% of antibody-negative diabetes cases listed in the Norwegian Childhood Diabetes Registry., PMID:27913849

Systematic Population Screening, Using Biomarkers and Genetic Testing, Identifies 2.5% of the U.K. Pediatric Diabetes Population With Monogenic Diabetes., PMID:27271189

Altered expression of ATP-sensitive K(+) channels in Hirschsprung's disease., PMID:27001456

Tuning the electrical properties of the heart by differential trafficking of KATP ion channel complexes., PMID:24569881

Evidences for an ATP-sensitive potassium channel (KATP) in muscle and fat body mitochondria of insect., PMID:23973818

Prevalence of monogenic diabetes in the population-based Norwegian Childhood Diabetes Registry., PMID:23624530

Enhancement of liver regeneration by adenosine triphosphate-sensitive K⁺ channel opener (diazoxide) after partial hepatectomy., PMID:22466787

KATP channels in mesenchymal stromal stem cells: strong up-regulation of Kir6.2 subunits upon osteogenic differentiation., PMID:21820692

Different localization of ATP sensitive K+ channel subunits in rat testis., PMID:21328565

Roles of sulfonylurea receptor 1 and multidrug resistance protein 1 in modulating insulin secretion in human insulinoma., PMID:21269941

Extracellular matrix modulates insulin production during differentiation of AR42J cells: functional role of Pax6 transcription factor., PMID:21069736

Disease progression and search for monogenic diabetes among children with new onset type 1 diabetes negative for ICA, GAD- and IA-2 Antibodies., PMID:20863361

Human oocytes express ATP-sensitive K(+) channels., PMID:20847183

Endoplasmic reticulum accumulation of Kir6.2 without activation of ER stress response in islet cells from adult Sur1 knockout mice., PMID:20383647

KATP channel subunits in rat dorsal root ganglia: alterations by painful axotomy., PMID:20102598

The KATP channel is a molecular sensor of atrophy in skeletal muscle., PMID:20064856

Glucose deprivation regulates KATP channel trafficking via AMP-activated protein kinase in pancreatic beta-cells., PMID:19720793

ATP-sensitive potassium currents in rat primary afferent neurons: biophysical, pharmacological properties, and alterations by painful nerve injury., PMID:19422886

[Hyperinsulinism in infancy and childhood: when an insulin level is not always enough]., PMID:19411227

Selective effect of INGAP-PP upon mouse embryonic stem cell differentiation toward islet cells., PMID:19159649

Mutations in the ABCC8 (SUR1 subunit of the K(ATP) channel) gene are associated with a variable clinical phenotype., PMID:19021632

Differential structure of atrial and ventricular KATP: atrial KATP channels require SUR1., PMID:18974387

Novel de novo mutation in sulfonylurea receptor 1 presenting as hyperinsulinism in infancy followed by overt diabetes in early adolescence., PMID:18390792

Effects of Abeta1-42 on the subunits of KATP expression in cultured primary rat basal forebrain neurons., PMID:18335313

Localization of the sulphonylurea receptor subunits, SUR2A and SUR2B, in rat renal tubular epithelium., PMID:18323694

Hyperinsulinism in infancy and childhood: when an insulin level is not always enough., PMID:18156285

Morphological localisation of sulfonylurea receptor 1 in endocrine cells of human, mouse and rat pancreas., PMID:17593344

Low levels of glucose transporters and K+ATP channels in human pancreatic beta cells early in development., PMID:17380317

Cerebral glucose transporters expression and spatial learning in the K-ATP Kir6.2(-/-) knockout mice., PMID:16797737

Generation of insulin-secreting cells from human embryonic stem cells., PMID:16759282

Neuronal responses to transient hypoglycaemia in the dorsal vagal complex of the rat brainstem., PMID:16284073

Lack of manifestations of diazoxide/5-hydroxydecanoate-sensitive KATP channel in rat brain nonsynaptosomal mitochondria., PMID:16051627

Subunit composition of ATP-sensitive potassium channels in mitochondria of rat hearts., PMID:16050978

Hyperinsulinemic hypoglycemia in Beckwith-Wiedemann syndrome due to defects in the function of pancreatic beta-cell adenosine triphosphate-sensitive potassium channels., PMID:15811927

Pore-forming subunits of K-ATP channels, Kir6.1 and Kir6.2, display prominent differences in regional and cellular distribution in the rat brain., PMID:15739238

Glucose- and interleukin-1beta-induced beta-cell apoptosis requires Ca2+ influx and extracellular signal-regulated kinase (ERK) 1/2 activation and is prevented by a sulfonylurea receptor 1/inwardly rectifying K+ channel 6.2 (SUR/Kir6.2) selective potassium channel opener in human islets., PMID:15220194

ATP-sensitive K(+) channels regulate the concentrative adenosine transporter CNT2 following activation by A(1) adenosine receptors., PMID:15024061

Heart mitochondria contain functional ATP-dependent K+ channels., PMID:14596790

Functional coupling between sulfonylurea receptor type 1 and a nonselective cation channel in reactive astrocytes from adult rat brain., PMID:13679426

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