Anti-P2X purinoceptor 4 Antibody (N368/71)

Catalog No.

RHK38103

Host species

Mouse

Isotype

IgG2a, kappa

Clonality

Monoclonal

Target

Purinergic receptor, P2RX4, P2X4, P2X purinoceptor 4, ATP receptor

Concentration

1 mg/ml

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Applications

IHC, WB

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Clone ID

N368/71

Impaired LPS Signaling in Macrophages Overexpressing the P2X7 C-Terminal Domain or Anti-P2X7 C-Terminal Domain Intrabody., PMID:39940947

The P2X7 Receptor is a Master Regulator of Microparticle and Mitochondria Exchange in Mouse Microglia., PMID:38984997

Preconditioning-Induced Facilitation of Lactate Release from Astrocytes Is Essential for Brain Ischemic Tolerance., PMID:38604775

Methods for studying P2X4 receptor ion channels in immune cells., PMID:38311008

Extracellular vesicles from oral mucosa stem cells promote lipid raft formation in human microglia through TLR4, P2X4R, and αVβ3/αVβ5 signaling pathways., PMID:38100213

Pharmacological interaction and immune response of purinergic receptors in therapeutic modulation., PMID:37843749

Purinergic 2X 4 (P2X4), but not P2X7, receptors increase cytosolic [Ca2+] and stimulate mucin secretion in rat conjunctival goblet cells to maintain ocular surface health., PMID:37580003

NLRP3 Inflammasome Activation Through Heart-Brain Interaction Initiates Cardiac Inflammation and Hypertrophy During Pressure Overload., PMID:36440584

Blocking P2X7 by intracerebroventricular injection of P2X7-specific nanobodies reduces stroke lesions., PMID:36224611

Improvement of the affinity of an anti-rat P2X4 receptor antibody by introducing electrostatic interactions., PMID:34996944

Single-Dose P2 X4R Single-Chain Fragment Variable Antibody Permanently Reverses Chronic Pain in Male Mice., PMID:34948407

Targeting Purinergic Receptor P2RX1 Modulates Intestinal Microbiota and Alleviates Inflammation in Colitis., PMID:34354708

Structural and Functional Features of the P2X4 Receptor: An Immunological Perspective., PMID:33897694

Immunohistochemical evidence of P2X7R, P2X4R and CaMKK2 in pyramidal neurons of frontal cortex does not align with Alzheimer's disease., PMID:33838119

Analysis of binding residues in monoclonal antibody with high affinity for the head domain of the rat P2X4 receptor., PMID:33169129

Inhibition of purinergic P2X receptor 7 (P2X7R) decreases granulocyte-macrophage colony-stimulating factor (GM-CSF) expression in U251 glioblastoma cells., PMID:32908225

The Purinergic Receptor P2rx3 is Required for Spiral Ganglion Neuron Branch Refinement during Development., PMID:32675174

Structure-based engineering of anti-GFP nanobody tandems as ultra-high-affinity reagents for purification., PMID:32277083

Long-lived T follicular helper cells retain plasticity and help sustain humoral immunity., PMID:32144185

Activation of P2X7R- NLRP3 pathway in Retinal microglia contribute to Retinal Ganglion Cells death in chronic ocular hypertension (COH)., PMID:31445901

Bacterial lipopolysaccharide and antimicrobial LL-37 enhance ICAM-1 expression and NF-κB p65 phosphorylation in senescent endothelial cells., PMID:31364735

The ATP-gated P2X1 ion channel contributes to the severity of antibody-mediated Transfusion-Related Acute Lung Injury in mice., PMID:30914724

ATP released by intestinal bacteria limits the generation of protective IgA against enteropathogens., PMID:30651557

Re-evaluation of neuronal P2X7 expression using novel mouse models and a P2X7-specific nanobody., PMID:30074479

The effect of neutralization of nerve growth factor (NGF) on bladder and urethral dysfunction in mice with spinal cord injury., PMID:29516546

Expression of purinergic P2X7 receptors in subpopulations of peripheral blood mononuclear cells in early-stage of chronic kidney disease., PMID:29375053

Corneal Neovascularization: A Combined Approach of Bevacizumab and Suramin Showed Increased Antiangiogenic Effect Through Downregulation of BFGF and P2X2., PMID:29265937

Purinergic 2X7 receptor activation regulates WNT signaling in human mandibular-derived osteoblasts., PMID:28549259

P2X7 nucleotide receptor signaling potentiates the Wnt/β-catenin pathway in cells of the osteoblast lineage., PMID:27206526

LncRNA NONRATT021972 siRNA regulates neuropathic pain behaviors in type 2 diabetic rats through the P2X7 receptor in dorsal root ganglia., PMID:27107575

High-efficiency antibody discovery achieved with multiplexed microscopy., PMID:27107009

Effect of axotomy and 17β-estradiol on P2X7 receptor expression pattern in the hypoglossal nucleus of ovariectomized mice., PMID:26826331

Mechanisms of NLRP3 inflammasome activation and its role in NSAID-induced enteropathy., PMID:26349656

Inhibition of antigen receptor-dependent Ca(2+) signals and NF-AT activation by P2X7 receptors in human B lymphocytes., PMID:25678443

Toll like receptor 2/1 mediated platelet adhesion and activation on bacterial mimetic surfaces is dependent on src/Syk-signaling and purinergic receptor P2X1 and P2Y12 activation., PMID:25553878

ATP-gated ionotropic P2X7 receptor controls follicular T helper cell numbers in Peyer's patches to promote host-microbiota mutualism., PMID:25464855

Differential effects of intestinal ischemia and reperfusion in rat enteric neurons and glial cells expressing P2X2 receptors., PMID:25400134

Trophic activity of human P2X7 receptor isoforms A and B in osteosarcoma., PMID:25226385

Vascular smooth muscle cells from small human omental arteries express P2X1 and P2X4 receptor subunits., PMID:24845338

Identification of P2X2/P2X4/P2X6 heterotrimeric receptors using atomic force microscopy (AFM) imaging., PMID:24815693

Comparative analysis of P2X1, P2X2, P2X3, and P2X4 receptor subunits in rat nodose ganglion neurons., PMID:24798490

3,4-Methylenedioxymethamphetamine (MDMA, ecstasy) disrupts blood-brain barrier integrity through a mechanism involving P2X7 receptors., PMID:24626059

Synergies of phosphatidylserine and protein disulfide isomerase in tissue factor activation., PMID:24452853

Mechanical vibration inhibits osteoclast formation by reducing DC-STAMP receptor expression in osteoclast precursor cells., PMID:23994170

Epistasis with HLA DR3 implicates the P2X7 receptor in the pathogenesis of primary Sjögren's syndrome., PMID:23819992

Oxidative stress induced by P2X7 receptor stimulation in murine macrophages is mediated by c-Src/Pyk2 and ERK1/2., PMID:23711511

P2X7 receptor-induced death of motor neurons by a peroxynitrite/FAS-dependent pathway., PMID:23646980

Spinal astrocytes produce and secrete dynorphin neuropeptides., PMID:23290538

Involvement of P2X(7) receptors in retinal ganglion cell death after optic nerve crush injury in rats., PMID:23262079

Involvement of the P2X7 purinergic receptor and c-Jun N-terminal and extracellular signal-regulated kinases in cyclooxygenase-2 and prostaglandin E2 induction by LL-37., PMID:23095809

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