Anti-Notch1 Antibody (N253/32)

Catalog No.

RHE48303

Host species

Mouse

Isotype

IgG2a, kappa

Clonality

Monoclonal

Target

hN1, TAN1, NEXT, NICD, Notch 1, Neurogenic locus notch homolog protein 1, Translocation-associated notch protein TAN-1, NOTCH1

Concentration

1 mg/ml

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Applications

IHC, WB

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Clone ID

N253/32

A ROS-Responsive Dual-Targeting Drug Nanocarrier Serving as a GSI Synergist and Ferroptosis Sensitizer for T-Cell Acute Lymphoblastic Leukemia., PMID:40448620

Co-inhibition of Notch1 and ChK1 triggers genomic instability and melanoma cell death increasing the lifespan of mice bearing melanoma brain metastasis., PMID:40437523

Mutation Mapping of PD-L1 Expression in Advanced Non-small Cell Lung Cancer: A Real-world Retrospective Cohort Study., PMID:40289990

Treatment outcomes of BTK inhibitors and venetoclax with or without anti-CD20 monoclonal antibody in relapsed or refractory mantle cell lymphoma., PMID:40278919

NOTCH1 Mutation and Survival Analysis of Tislelizumab in Advanced or Metastatic Esophageal Squamous Cell Carcinoma: A Biomarker Analysis From the Randomized, Phase III, RATIONALE-302 Trial., PMID:40179324

Evaluation of Notch1 and CD10 Expressions in Colorectal Carcinoma and Their Relationship with Prognosis., PMID:40060224

Clinical Outcomes With Notch Inhibitors in Notch-Activated Recurrent/Metastatic Adenoid Cystic Carcinoma., PMID:40025676

Synapsin III promotes neuronal-like transdifferentiation of glioblastoma stem cells by disrupting JAG1-Notch1 interaction., PMID:39994412

The interplay of cancer-associated fibroblasts and apoptotic cancer cells suppresses lung cancer cell growth through WISP-1-integrin ανβ3-STAT1 signaling pathway., PMID:39966869

The potential role of RhoA/ROCK-inhibition on locomotor recovery after spinal cord injury: a systematic review of in-vivo studies., PMID:39956860

Melatonin ameliorates astrogliosis and microgliosis in a cuprizone demyelinating mouse model., PMID:39926210

Association of Specific Gene Mutations with Immunoglobulin Heavy-Chain Variable Region and Chromosomal Alterations in Chronic Lymphocytic Leukemia Patients in India., PMID:39873992

NOTCH1 Mutations Are Associated With Therapy-Resistance in Patients With B-Cell Lymphoma Treated With CD20xCD3 Bispecific Antibodies., PMID:39865309

Sirt6 regulates the Notch signaling pathway and mediates autophagy and regulates podocyte damage in diabetic nephropathy., PMID:39754634

Targeted delivery of DAPT using dual antibody functionalized solid lipid nanoparticles for enhanced anti-tumour activity against triple negative breast cancer., PMID:39746584

Retinal Müller Cell-Released Exosomal MiR-92a-3p Delivers Interleukin-17A Signal by Targeting Notch-1 to Promote Diabetic Retinopathy., PMID:39745681

Prognostic and predictive impact of NOTCH1 mutation in chronic lymphocytic leukemia: a systematic review., PMID:39727347

USP18-mediated protein stabilization of NOTCH1 is associated with altered Th17/Treg cell ratios and B cell-mediated autoantibody secretion in Sjögren syndrome., PMID:39672989

Bevacizumab increases cisplatin efficacy by inhibiting epithelial-mesenchymal transition via ALDH1 in cervical carcinoma., PMID:39662269

The Jag2/Notch1 signaling axis promotes sebaceous gland differentiation and controls progenitor proliferation., PMID:39585329

Modulation of Notch signaling pathway in activated hepatic stellate cells does not ameliorate the outcome of liver fibrosis in carbon tetrachloride and DDC-feeding models., PMID:39529885

Notch1 blockade by a novel, selective anti-Notch1 neutralizing antibody improves immunotherapy efficacy in melanoma by promoting an inflamed TME., PMID:39491031

NOTCH1 drives tumor plasticity and metastasis in hepatocellular carcinoma., PMID:39484457

VASN promotes the aggressive phenotype in ARID1A-deficient lung adenocarcinoma., PMID:39472811

Dynamic roles of neutrophil extracellular traps in cancer cell adhesion and activation of Notch 1-mediated epithelial-to-mesenchymal transition in EGFR-driven lung cancer cells., PMID:39430758

Identification of DLK1, a Notch ligand, as an immunotherapeutic target and regulator of tumor cell plasticity and chemoresistance in adrenocortical carcinoma., PMID:39416174

Astrocytic DLL4-NOTCH1 signaling pathway promotes neuroinflammation via the IL-6-STAT3 axis., PMID:39390606

Advances in the understanding of molecular genetics and therapy of Richter transformation in chronic lymphocytic leukemia., PMID:39219481

Mechanistic Insights and Therapeutic Strategies in Osteoporosis: A Comprehensive Review., PMID:39200100

NOTCH1- and CD117-Positive Stem Cells in Human Endometriosis and Adenomyosis Lesions., PMID:39125516

Brain ischemia causes systemic Notch1 activity in endothelial cells to drive atherosclerosis., PMID:39079536

Inhibition of Notch4 Using Novel Neutralizing Antibodies Reduces Tumor Growth in Murine Cancer Models by Targeting the Tumor Endothelium., PMID:38984877

Another Notch in the Belt of Rheumatoid Arthritis., PMID:38961731

Molecular hydrogen promotes retinal vascular regeneration and attenuates neovascularization and neuroglial dysfunction in oxygen-induced retinopathy mice., PMID:38915069

Jagged2 targeting in lung cancer activates anti-tumor immunity via Notch-induced functional reprogramming of tumor-associated macrophages., PMID:38636522

Therapeutic Advances and Challenges for the Management of HPV-Associated Oropharyngeal Cancer., PMID:38612819

Gamma-delta T-cell acute lymphoblastic lymphoma/leukemia: a report of a rare entity., PMID:38528212

Efficient Escorting Strategy for Aggregation-Prone Notch EGF Repeats with Sparcl1., PMID:38474544

Mutational, immune microenvironment, and clinicopathological profiles of diffuse large B-cell lymphoma and follicular lymphoma with BCL6 rearrangement., PMID:38462571

Epithelium-derived kallistatin promotes CD4+ T-cell chemotaxis to TH2-type inflammation in chronic rhinosinusitis., PMID:38403085

Notch-1/2 receptors and Jagged-1 ligand, but not HERP-1 transcription factor, are immunohistochemically expressed in the epithelial lining of periapical cysts., PMID:38314334

Gamma protocadherins in vascular endothelial cells inhibit Klf2/4 to promote atherosclerosis., PMID:38293157

Activation of Notch-1 signaling pathway in macrophages to secrete PD-L1 and regulate cytotoxicity of CAR-T cells in diffuse large B-cell lymphoma., PMID:38261741

Anti-NOTCH1 therapy with OMP-52 M51 inhibits salivary adenoid cystic carcinoma by depressing epithelial-mesenchymal transition (EMT) process and inducing ferroptosis., PMID:38253083

Chronic Lymphocytic Leukemia IGHV Somatic Hypermutation Detection by Targeted Capture Next-Generation Sequencing., PMID:38175592

Notch signaling in thyrocytes is essential for adult thyroid function and mammalian homeostasis., PMID:38123718

The Notch1 signaling pathway directly modulates the human RANKL-induced osteoclastogenesis., PMID:38040752

Notch ligands are biomarkers of anti-TNF response in RA patients., PMID:37796367

Targeting NOTCH1 in combination with antimetabolite drugs prolongs life span in relapsed pediatric and adult T-acute lymphoblastic leukemia xenografts., PMID:37667380

The beneficial effects of l-carnitine and infliximab in methotrexate-induced hepatotoxicity: Emphasis on Notch1/Hes-1 signaling., PMID:37625018

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