Catalog No.
RHD66002
Host species
Mouse
Isotype
IgG2a, kappa
Clonality
Monoclonal
Target
TAC1R, Tachykinin receptor 1, NK-1R, NK1R, SPR, TACR1, Substance-P receptor, NK-1 receptor
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Applications
IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
N188/40
Semi-synthetic nanobody-ligand conjugates exhibit tunable signaling properties and enhanced transcriptional outputs at neurokinin receptor-1., PMID:38088474
Semi-synthetic nanobody-ligand conjugates exhibit tunable signaling properties and enhanced transcriptional outputs at neurokinin receptor-1., PMID:37986858
Lessons learned in translating pain knowledge into practice., PMID:37928204
Association between tissue stress reaction and ACE2/TMPRSS2 expression in endometria of reproductive aged women before and during Covid-19 pandemic., PMID:37142998
K+ channel Kv4.1 is expressed in the nociceptors/secondary nociceptive neurons and participates in pain regulation., PMID:36097791
Enhanced Neurokinin-1 Receptor Expression Is Associated with Human Dental Pulp Inflammation and Pain Severity., PMID:34041298
Elevated Neurokinin-1 Receptor Expression in Uterine Products of Conception Is Associated With First Trimester Miscarriages., PMID:33391008
Neurogenic tachykinin mechanisms in experimental nephritis of rats., PMID:33070237
c-Kit-stem cell factor signal-independent development of interstitial cells of Cajal in murine small intestine., PMID:31741038
Pathophysiologic mechanisms of itch in bullous pemphigoid., PMID:31351883
[The effect of NK-1R-siRNA on expression of inflammatory factors in allergic rhinitis]., PMID:30991778
Bilateral muscle fiber and nerve influences by TNF-alpha in response to unilateral muscle overuse - studies on TNF receptor expressions., PMID:29183282
Manifestation of atopic dermatitis-like skin in TNCB-induced NC/Nga mice is ameliorated by topical treatment of substance P, possibly through blockade of allergic inflammation., PMID:28833499
Substance P-mediated chemokine production promotes monocyte migration., PMID:28366881
Mas-related G protein coupled receptor-X2: A potential new target for modulating mast cell-mediated allergic and inflammatory diseases., PMID:28090599
Specific inhibition of ICAM-1 effectively reduces bladder inflammation in a rat model of severe non-bacterial cystitis., PMID:27782122
Upregulated expression of substance P in basophils of the patients with chronic spontaneous urticaria: induction of histamine release and basophil accumulation by substance P., PMID:27147256
Substance P excites GABAergic neurons in the mouse central amygdala through neurokinin 1 receptor activation., PMID:26334021
Autocrine hemokinin-1 functions as an endogenous adjuvant for IgE-mediated mast cell inflammatory responses., PMID:25201259
Absence of substance P and the sympathetic nervous system impact on bone structure and chondrocyte differentiation in an adult model of endochondral ossification., PMID:25063231
Changes in glutamate receptor subunits within the medulla in goats after section of the carotid sinus nerves., PMID:24790015
Localisation and activation of the neurokinin 1 receptor in the enteric nervous system of the mouse distal colon., PMID:24728885
Intrathecal substance P-saporin in the dog: distribution, safety, and spinal neurokinin-1 receptor ablation., PMID:24051388
Substance P autocrine signaling contributes to persistent HER2 activation that drives malignant progression and drug resistance in breast cancer., PMID:24030979
Sex differences in formalin-evoked primary afferent release of substance P., PMID:23754308
Sudden death following selective neuronal lesions in the rat nucleus tractus solitarii., PMID:23245583
Neurokinin-1 receptor directly mediates glioma cell migration by up-regulation of matrix metalloproteinase-2 (MMP-2) and membrane type 1-matrix metalloproteinase (MT1-MMP)., PMID:23166329
Expression of proliferative markers in ameloblastomas and malignant odontogenic tumors., PMID:22970847
Atomic force microscopy to characterize binding properties of α7-containing nicotinic acetylcholine receptors on neurokinin-1 receptor-expressing medullary respiratory neurons., PMID:22962286
Truncated neurokinin-1 receptor is increased in colonic epithelial cells from patients with colitis-associated cancer., PMID:21969570
Spinal botulinum neurotoxin B: effects on afferent transmitter release and nociceptive processing., PMID:21559464
Early potential impairment of renal sensory nerves in streptozotocin-induced diabetic rats: role of neurokinin receptors., PMID:20732924
Substance P downregulates expression of the high affinity IgE receptor (FcepsilonRI) by human mast cells., PMID:20117843
An engineered substance P variant for receptor-mediated delivery of synthetic antibodies into tumor cells., PMID:19549879
A role for the substance P/NK-1 receptor complex in cell proliferation in oral squamous cell carcinoma., PMID:19528498
Exercise reduces GABA synaptic input onto nucleus tractus solitarii baroreceptor second-order neurons via NK1 receptor internalization in spontaneously hypertensive rats., PMID:19261870
Neurokinin 1 receptor-expressing projection neurons in laminae III and IV of the rat spinal cord have synaptic AMPA receptors that contain GluR2, GluR3 and GluR4 subunits., PMID:19200070
A role for the substance P/NK-1 receptor complex in cell proliferation and apoptosis in oral lichen planus., PMID:19036058
Cell proliferation associated with actions of the substance P/NK-1 receptor complex in keratocystic odontogenic tumours., PMID:18486533
Noxious mechanical stimulation evokes the segmental release of opioid peptides that induce mu-opioid receptor internalization in the presence of peptidase inhibitors., PMID:18207137
OVARIAN CANCER SUICIDE GENE THERAPY WITH GENETICALLY ENGINEERED, TRANSGENICALLY EXPRESSED, INTRACELLULAR scFv ANTIBODIES AGAINST ANTI-OXIDATIVE ENZYMES., PMID:23243327
Neuropeptides activate human mast cell degranulation and chemokine production., PMID:17922833
Generation of a transgenic model to address regulation and function of the human neurokinin 1 receptor (NK1R)., PMID:17576012
Correlation between the appearance of neuropeptides in the rat trigeminal ganglion and reinnervation of the healing root socket after tooth extraction., PMID:17327926
Phosphorylation of ERK in neurokinin 1 receptor-expressing neurons in laminae III and IV of the rat spinal dorsal horn following noxious stimulation., PMID:17309799
Upregulation of the axonal growth and the expression of substance P and its NK1 receptor in human allergic contact dermatitis., PMID:17190739
Neurokinin-1 and neurokinin-3 receptors in primate substantia nigra., PMID:17134780
Morphine upregulates functional expression of neurokinin-1 receptor in neurons., PMID:16983662
Ubiquitin-dependent down-regulation of the neurokinin-1 receptor., PMID:16849335
Morphology and neurokinin 1 receptor expression of spinothalamic lamina I neurons in the rat spinal cord., PMID:16127696
For research use only. Not for human or drug use.
