Catalog No.
RHD30702
Host species
Mouse
Isotype
IgG2a, kappa
Clonality
Monoclonal
Target
ADRA2L2, ADRA2C, Alpha-2CAR, Alpha-2C adrenoreceptor, Alpha-2C adrenoceptor, Alpha-2C adrenergic receptor, ADRA2RL2, Alpha-2 adrenergic receptor subtype C4
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Applications
IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
N330A/80
Tumour immune rejection triggered by activation of α2-adrenergic receptors., PMID:37286594
Dexmedetomidine attenuates lipopolysaccharide-induced inflammation through macrophageal IL-10 expression following α7 nAchR activation., PMID:35691275
Distribution and relative expression of vasoactive receptors on arteries., PMID:32958803
Pharmacological Characterization of a Novel Mouse Model of Cholestatic Pruritus., PMID:32612073
Changes in TRPV1 expression in the POA of ovariectomized rats regulated by NE-dependent α2-ADR may be involved in hot flashes., PMID:32603826
Postural Orthostatic Tachycardia Syndrome Is Associated With Elevated G-Protein Coupled Receptor Autoantibodies., PMID:31495251
PtdIns(4,5)P2 stabilizes active states of GPCRs and enhances selectivity of G-protein coupling., PMID:29995853
Regulation of corneal noradrenaline release and topography of sympathetic innervation: Functional implications for adrenergic mechanisms in the human cornea., PMID:29803557
Neuroprotective effect of dexmedetomidine in a murine model of traumatic brain injury., PMID:29563509
The Biogenic Amine Tyramine and its Receptor (AmTyr1) in Olfactory Neuropils in the Honey Bee (Apis mellifera) Brain., PMID:29114209
Non-amyloidogenic effects of α2 adrenergic agonists: implications for brimonidine-mediated neuroprotection., PMID:27929541
Immunohistochemical localization of alpha and beta adrenergic receptors in the human nasal turbinate., PMID:26739946
Disruption of Spinal Noradrenergic Activation Delays Recovery of Acute Incision-Induced Hypersensitivity and Increases Spinal Glial Activation in the Rat., PMID:26545342
Multidimensional GPCR profiling and screening using impedance-based label-free and real-time assay., PMID:25563187
Plasticity of α2-adrenergic spinal antinociception following nerve injury: selective, bidirectional interaction with the delta opioid receptor., PMID:25446445
Differential expression of alpha-adrenoceptor subtypes in rat dorsal root ganglion after chronic constriction injury., PMID:24939293
Effects of dexmedetomidine on P2X4Rs, p38-MAPK and BDNF in spinal microglia in rats with spared nerve injury., PMID:24792496
Blockade of platelet alpha2B-adrenergic receptors: a novel antiaggregant mechanism., PMID:23582690
Systematic and quantitative analysis of G protein-coupled receptor trafficking motifs., PMID:23351739
Sex, pain, and opioids: interdependent influences of sex and pain modality on dynorphin-mediated antinociception in rats., PMID:23230215
Activation of extracellular-signal regulated kinase by epidermal growth factor is potentiated by cAMP-elevating agents in primary cultures of adult rat hepatocytes., PMID:21963493
Modulation of immune cell function by α(1)-adrenergic receptor activation., PMID:21771488
Chromaffin cell transplant in spinal cord reduces secondary allodynia induced by formalin in the rat. Role of opioid receptors and α₂-adrenoceptors., PMID:21741968
Effects of chronic treatment with fluoxetine on receptor-stimulated increase of [Ca2+]i in astrocytes mimic those of acute inhibition of TRPC1 channel activity., PMID:21640379
Effects of dexmedetomidine on the release of glial cell line-derived neurotrophic factor from rat astrocyte cells., PMID:21241763
Association analysis about HLA-DRB1, -DQB1 polymorphism and auto-antibodies against α(1)-adrenergic receptors in Chinese patients with essential hypertension., PMID:21091360
Investigation of the distribution and function of alpha-adrenoceptors in the sheep isolated internal anal sphincter., PMID:20649575
Spinal alpha 2-adrenoceptor-mediated analgesia in neuropathic pain reflects brain-derived nerve growth factor and changes in spinal cholinergic neuronal function., PMID:20613480
Alpha2-adrenergic receptors and their core involvement in the process of axonal growth in retinal explants., PMID:20592227
Marked behavioral activation from inhibitory stimulation of locus coeruleus alpha1-adrenoceptors by a full agonist., PMID:19632210
Cannabinoid modulation of cortical adrenergic receptors and transporters., PMID:19533736
Analysis of alpha2-adrenergic receptors and effect of brimonidine on matrix metalloproteinases and their inhibitors in human ciliary body., PMID:19324857
Epitope-tagged receptor knock-in mice reveal that differential desensitization of alpha2-adrenergic responses is because of ligand-selective internalization., PMID:19276088
Adrenergic regulation of cAMP/protein kinase A pathway in corneal epithelium and endothelium., PMID:18688175
The ATP-gated P2X1 receptor plays a pivotal role in activation of aspirin-treated platelets by thrombin and epinephrine., PMID:18480058
Marked sympathetic component in the perivascular innervation of the dorsal paratendinous tissue of the patellar tendon in arthroscopically treated tendinosis patients., PMID:18418576
Localization of alpha 2 receptors in ocular tissues., PMID:17986363
Upregulation of soluble vascular endothelial growth factor receptor 1 contributes to angiogenesis defects in the placenta of alpha 2B-adrenoceptor deficient mice., PMID:17673674
Calcitonin receptor-like receptor and receptor activity modifying protein 1 in the rat dorsal horn: localization in glutamatergic presynaptic terminals containing opioids and adrenergic alpha2C receptors., PMID:17614212
Alpha-adrenergic mRNA subtype expression in the human nasal turbinate., PMID:17602041
Extracellular signal-regulated kinase 1/2-mediated transcriptional regulation of G-protein-coupled receptor kinase 3 expression in neuronal cells., PMID:17255468
Neuronal nitric oxide synthase is upregulated in a subset of primary sensory afferents after nerve injury which are necessary for analgesia from alpha2-adrenoceptor stimulation., PMID:17113051
Beta-amyloid-dependent expression of NOS2 in neurons: prevention by an alpha2-adrenergic antagonist., PMID:16771677
Factor XII (Hageman factor) is a missing link between stress and hypercoagulability and plays an important role in the pathophysiology of ischemic stroke., PMID:16757126
Identification of functional alpha2- and beta-adrenergic receptors in mammalian spermatozoa., PMID:16488904
Alpha2-adrenergic receptors are present in normal human conjunctiva., PMID:16354626
Role of metalloproteinase-dependent EGF receptor activation in alpha-adrenoceptor-stimulated MAP kinase phosphorylation in GT1-7 neurons., PMID:16336626
Human breast cell lines exhibit functional alpha2-adrenoceptors., PMID:16292538
Effect of anti-NGF on ovarian expression of alpha1- and beta2-adrenoceptors, TrkA, p75NTR, and tyrosine hydroxylase in rats with steroid-induced polycystic ovaries., PMID:16195501
Alpha2-adrenoceptor stimulation transforms immune responses in neuritis and blocks neuritis-induced pain., PMID:16192389
For research use only. Not for human or drug use.
