Catalog No.
DHE84699
Description
Codrituzumab-MMAE is an ADC consisting of a GPC3-directed antibody and Monomethyl auristatin E (MMAE) used for the study of hepatocellular carcinoma.
Species reactivity
Human
Clonality
Monoclonal
Target
GPC3
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SEC.
Purification
Purified by Ion Exchange Chromatography.
Applications
Research Grade Biosimilar
Form
Liquid
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
Codrituzumab-MMAE
Glypican-3 is a key tuner of the Hedgehog pathway in COPD., PMID:39844999
Glypican-3 deficiency in liver cancer upregulates MAPK/ERK pathway but decreases cell proliferation., PMID:39113871
H2BZmacropa-NCS: A Bifunctional Chelator for Actinium-225 Targeted Alpha Therapy., PMID:35670495
Glypican-3-Targeted Alpha Particle Therapy for Hepatocellular Carcinoma., PMID:33374953
Heparan sulfate proteoglycans as targets for cancer therapy: a review., PMID:33180600
Evaluation of Targeted Agents for Advanced and Unresectable Hepatocellular Carcinoma: A Network Meta-Analysis., PMID:31528232
Glypican 3-Targeted Therapy in Hepatocellular Carcinoma., PMID:31510063
Case-control Indian buffet process identifies biomarkers of response to Codrituzumab., PMID:30922327
Combining expression of GPC3 in tumors and CD16 on NK cells from peripheral blood to identify patients responding to codrituzumab., PMID:29535817
I-124 codrituzumab imaging and biodistribution in patients with hepatocellular carcinoma., PMID:29508107
Time-to-event modelling of effect of codrituzumab on overall survival in patients with hepatocellular carcinoma., PMID:29381229
Phase Ib study of codrituzumab in combination with sorafenib in patients with non-curable advanced hepatocellular carcinoma (HCC)., PMID:28120036
Randomized phase II placebo controlled study of codrituzumab in previously treated patients with advanced hepatocellular carcinoma., PMID:27085251
For research use only. Not for human or drug use.
