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Tisotumab vedotin (ADC)

Catalog #:   DHD00699 Specific References (48) DATASHEET
Applications: Research Grade Biosimilar
Overview

Catalog No.

DHD00699

Description

Tisotumab vedotin is an ADC consisting of a Tissue Factor-directed antibody and Monomethyl auristatin E (MMAE) used for the study of cervical cancer.

Species reactivity

Human

Clonality

Monoclonal

Target

TissueFactor

Concentration

1 mg/ml

Endotoxin level

Please contact with the lab for this information.

Purity

>90% as determined by SEC.

Purification

Purified by Ion Exchange Chromatography.

Applications

Research Grade Biosimilar

Form

Liquid

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Alternative Names

TIVDAK

Clone ID

Tisotumab vedotin

Data Image
References

The efficacy and safety of Tisotumab vedotin in the treatment of recurrent/metastatic cervical cancer: a systematic review and meta-analysis of single-arm studies., PMID:40458792

Rapidly progressive pneumonitis days after receiving tisotumab vedotin: a new antibody-drug conjugate., PMID:40234078

PMDA regulatory update on approval and revision of the precautions for use of anticancer drugs; approval of amivantamab plus lazertinib for non-small cell lung cancer, durvalumab for small cell lung cancer, tislelizumab for esophageal cancer, tisotumab vedotin for cervical cancer, ivosidenib for leukemia, and venetoclax for lymphoma in Japan., PMID:40214878

Clinical applications of antibody drug conjugates for gynecologic malignancies: Review of available medicines and emerging therapeutics., PMID:40139025

Second-line antibody-drug conjugates for the treatment of metastatic human papillomavirus-independent gastric-type adenocarcinoma of cervix: The Singapore experience., PMID:40115377

F3 Expression Drives Sensitivity to the Antibody-Drug Conjugate Tisotumab Vedotin in Glioblastoma., PMID:40075681

Practical clinical management of ocular adverse events related to Antibody-Drug Conjugates in gynaecological malignancies., PMID:39970828

Ocular surface disease related to tisotumab vedotin-tftv., PMID:39877468

Ocular adverse events associated with antibody-drug conjugates: a comprehensive pharmacovigilance analysis., PMID:39742259

Antibody-Drug Conjugates: The Toxicities and Adverse Effects That Emergency Physicians Must Know., PMID:39641680

Antibody-Drug Conjugates: A Start of a New Era in Gynecological Cancers., PMID:39590153

Tisotumab vedotin extravasation injury in a patient with recurrent cervical cancer., PMID:39431057

Safety and efficacy of tisotumab vedotin with cervical cancers: A systematic review and meta-analysis., PMID:39428336

Real-World Large Sample Assessment of Drug-related Dry Eye Risk: Based on the FDA Adverse Event Reporting System Database., PMID:39343068

Antibody drug conjugates in recurrent or metastatic cervical cancer: a focus on tisotumab vedotin state of art., PMID:39323928

Anti-tissue factor antibody conjugated with monomethyl auristatin E or deruxtecan in pancreatic cancer models., PMID:39322584

Pharmacovigilance study of the association between peripheral neuropathy and antibody-drug conjugates using the FDA adverse event reporting system., PMID:39271716

Discrepancy in PD-L1 expression between primary and metastatic tumors in two patients with recurrent cervical cancer., PMID:39252760

[Antibody-Drug Conjugates in Breast Cancer and Gynecologic Cancer]., PMID:39191683

Accuracy and Completeness of Large Language Models About Antibody-Drug Conjugates and Associated Ocular Adverse Effects., PMID:39110155

Tisotumab vedotin effective in recurrent cervical cancer., PMID:39039198

Tisotumab Vedotin as Second- or Third-Line Therapy for Recurrent Cervical Cancer., PMID:38959480

Tisotumab vedotin (Tivdak) for cervical cancer., PMID:38905529

Ocular toxicities associated with antibody drug conjugates., PMID:38814581

Exploring tisotumab vedotin in recurrent cervical cancer: A case series including an HPV-independent gastric type adenocarcinoma., PMID:38523623

Cost effectiveness of immunotherapy combination therapies for endometrial cancer., PMID:38449799

Recent Therapeutic Advances in Gynecologic Oncology: A Review., PMID:38398161

Cost-effectiveness of tisotumab vedotin as a second- or third-line therapy for cervical cancer., PMID:38330381

Acute keratoconjunctivitis associated with tisotumab vedotin-tftv for metastatic cervical cancer., PMID:38230392

Antibody-Drug Conjugates in Gynecologic Cancers., PMID:38172449

Assessing safety concerns of interstitial lung disease associated with antibody-drug conjugates: a real-world pharmacovigilance evaluation of the FDA adverse event reporting system., PMID:38100054

A review of the state of cervical cancer: updates from prevention to recurrent disease., PMID:37873756

An Antibody-Drug Conjugate Directed to Tissue Factor Shows Preclinical Antitumor Activity in Head and Neck Cancer as a Single Agent and in Combination with Chemoradiotherapy., PMID:37828725

New Paradigms in the Treatment of Cervical Cancer., PMID:37826852

SGN-B7H4V, an investigational vedotin ADC directed to the immune checkpoint ligand B7-H4, shows promising activity in preclinical models., PMID:37793853

Therapeutic Potential of Tisotumab Vedotin in the Treatment of Recurrent or Metastatic Cervical Cancer: A Short Report on the Emerging Data., PMID:37790898

Uncovering therapeutic opportunities in the clinical development of antibody-drug conjugates., PMID:37740463

Tisotumab Vedotin in Combination With Carboplatin, Pembrolizumab, or Bevacizumab in Recurrent or Metastatic Cervical Cancer: Results From the innovaTV 205/GOG-3024/ENGOT-cx8 Study., PMID:37651655

Sequential Targeted Therapy for Advanced, Metastatic, and Recurrent Cervical Cancer: A Cost-Effectiveness Analysis of the Patient Journey., PMID:37646470

Antibody-Drug Conjugates in Solid Tumor Oncology: An Effectiveness Payday with a Targeted Payload., PMID:37631374

Antibody-Drug Conjugates: A Review of Approved Drugs and Their Clinical Level of Evidence., PMID:37568702

The abscopal effect of immune-radiation therapy in recurrent and metastatic cervical cancer: a narrative review., PMID:37539054

Exposure-safety and exposure-efficacy analyses for tisotumab vedotin for patients with locally advanced or metastatic solid tumors., PMID:37496366

Tissue factor (coagulation factor III): a potential double-edge molecule to be targeted and re-targeted toward cancer., PMID:37280670

Antibody-Drug Conjugates in Gynecologic Cancer., PMID:37229642

The evolving landscape of antibody-drug conjugates in gynecologic cancers., PMID:37023499

Tisotumab Vedotin Safety and Tolerability in Clinical Practice: Managing Adverse Events., PMID:37009403

Integrating antibody drug conjugates in the management of gynecologic cancers., PMID:36878560

Datasheet

Document Download

Tisotumab vedotin (ADC).pdf

 

$ 2540
Product specifications
1 mg 2540 5 mg 6360

Contact Information

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Mail: support@antibodysystem.com

Distributor list

For research use only. Not for human or drug use.

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Tisotumab vedotin (ADC) [DHD00699]
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