Catalog No.
EHE30302
Expression system
Mammalian Cells
Species
Homo sapiens (Human)
Protein length
Gln31-Gly232
Predicted molecular weight
25.64 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P41217
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution.A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
OX-2 membrane glycoprotein, CD200, CD200, MOX1, MOX2, My033
CD200R1-CD200 checkpoint inhibits phagocytosis differently from SIRPα-CD47 to suppress tumor growth., PMID:40461553
Mapping Inherited Genetic Variation with Opposite Effects on Autoimmune Disease and Four Cancer Types Identifies Candidate Drug Targets Associated with the Anti-Tumor Immune Response., PMID:40428397
Genomic and transcriptomic determinants of clinical outcomes in patients with AML and DNMT3A mutations., PMID:40389402
CD200 in acute myeloid leukemia: marked upregulation in CEBPA biallelic mutated cases., PMID:40307896
Inhibition of polymorphonuclear cells averts cytotoxicity against hypoimmune cells in xenotransplantation., PMID:40251154
Regulation mechanism of chemokine CXCL3 in nasopharyngeal carcinoma., PMID:40239601
Low Intratumoral CD200 Protein Expression in Primary Merkel Cell Carcinoma Is a Strong Predictor for Disease Relapse., PMID:40075669
Monocytes from patients with myelodysplastic syndrome inhibit natural killer cell-mediated antitumor function through the CD200/CD200R pathway., PMID:40049088
Effects of Oral Administration of the Probiotic Lactobacillus rhamnosus GG on the Proteomic Profiles of Cerebrospinal Fluid and Immunoregulatory Signaling in the Hippocampus of Adult Male Rats., PMID:40031897
Polymorphisms in immunosuppression-related genes are associated with AML., PMID:39975548
Targeting CD200 in Breast Cancer: Opportunities and Challenges in Immunotherapeutic Strategies., PMID:39795972
Bone marrow niches orchestrate stem-cell hierarchy and immune tolerance., PMID:39743593
First-in-Human Study of 23ME-00610, an Antagonistic Antibody for Genetically Validated CD200R1 Immune Checkpoint, in Participants with Advanced Solid Malignancies., PMID:39651931
Ageing-related changes in the regulation of microglia and their interaction with neurons., PMID:39617175
Exosomes derived from Umbilical cord mesenchymal stem cell promote hair regrowth in C57BL6 mice through upregulation of the RAS/ERK signaling pathway., PMID:39513036
Leukemic B cells expression of CD200 and Leukocyte-associated immunoglobulin-like receptor-1 (LAIR-1, CD305) in Chronic Lymphocytic Leukemia patients in relation to Treg frequency., PMID:39471525
Intranasal sensitization model of alopecia areata using pertussis toxin as adjuvant., PMID:39450167
Description and functional validation of human enteroendocrine cell sensors., PMID:39418382
CD200R1 immune checkpoint blockade by the first-in-human anti-CD200R1 antibody 23ME-00610: molecular mechanism and engineering of a surrogate antibody., PMID:39402718
CD200 depletion in glioma enhances antitumor immunity and induces tumor rejection., PMID:39314283
Characterisation of cells markers associated with IKZF1plus in BCP-ALL., PMID:39312877
A squalene oil emulsified MPL-A and anti-CD200/CD300a antibodies adjuvanted whole-killed Leishmania vaccine provides durable immunity against L. donovani parasites., PMID:39288578
Apoptosis Regulation in Dental Pulp Cells and PD-1/PD-L1 Expression Dynamics Under Ozone Exposure - A Pilot Approach., PMID:39277882
Endothelial Cell-Derived Soluble CD200 Determines the Ability of Immune Cells to Cross the Blood-Brain Barrier., PMID:39273210
Cellular heterogeneity of pluripotent stem cell-derived cardiomyocyte grafts is mechanistically linked to treatable arrhythmias., PMID:39196193
Differences in immunological profile in atopic dermatitis patients with and without dupilumab therapy., PMID:39148480
Pan-cancer analysis of immune checkpoint receptors and ligands in various cells in the tumor immune microenvironment., PMID:39120585
Impaired Epithelial CD200L Tolerance Signaling in Irritable Bowel Syndrome Cases With Diarrhea May Be Associated With Recurrent Miscarriages., PMID:39113660
Exploring markers of immunoresponsiveness in papillary thyroid carcinoma and future treatment strategies., PMID:39074963
The Immunological Profile of Adipose Mesenchymal Stromal/Stem Cells after Cell Expansion and Inflammatory Priming., PMID:39062566
[FAPI-PET-CT for quantification of the tissue response in rheumatic diseases]., PMID:39031195
Immunophenotypic Profile and Measurable Residual Disease Monitoring in Multiple Myeloma: A Prospective Study From a Tertiary Care Centre in Southern India., PMID:38952609
In Silico Exploration of CD200 as a Therapeutic Target for COVID-19., PMID:38930566
Interleukin-6 Signaling Blockade Induces Regulatory Plasmablasts in Neuromyelitis Optica Spectrum Disorder., PMID:38889374
CD200R activation on naïve T cells by B cells induces suppressive activity of T cells via IL-24., PMID:38780647
Molecular incompatibility between pig CD200 and human CD200 receptor in in vitro xenogeneic immune responses., PMID:38751087
Myeloid cell expression of CD200R is modulated in active TB disease and regulates Mycobacterium tuberculosis infection in a biomimetic model., PMID:38745652
Bioinformatic analysis of the role of immune checkpoint genes and immune infiltration in the pathogenesis and development of premature ovarian insufficiency., PMID:38695984
CD200 is overexpressed in the pancreatic tumor microenvironment and predictive of overall survival., PMID:38619621
DNA methylation of microRNA-365-1 induces apoptosis of hair follicle stem cells by targeting DAP3., PMID:38616861
The association between expression of CD200 on B lymphocytes and the count of eosinophils and basophils in atopic dermatitis patients with and without dupilumab therapy - Pilot study., PMID:38603859
[IL-1β inhibits macrophage M2 polarization by down-regulating CD200 expression in human umbilical cord mesenchymal stem cells]., PMID:38512028
Dandruff lesional scalp skin exhibits epidermal T cell infiltration and a weakened hair follicle immune privilege., PMID:38488328
JAM3: A prognostic biomarker for bladder cancer via epithelial-mesenchymal transition regulation., PMID:38400838
CD200+ fibroblasts form a pro-resolving mesenchymal network in arthritis., PMID:38396288
Inflammatory dendritic cells restrain CD11b+CD4+ CTLs via CD200R in human NSCLC., PMID:38354085
CD200Rhigh neutrophils with dysfunctional autophagy establish systemic immunosuppression by increasing regulatory T cells., PMID:38311677
The expression of CD200 and CD23 on B lymphocytes in the pollen season and outside the pollen season in atopic dermatitis patients with and without dupilumab therapy., PMID:38263709
Expression of Elafin and CD200 as Immune Checkpoint Molecules Involved in Celiac Disease., PMID:38255930
Activation of the CD200/CD200R1 axis improves cognitive impairment by enhancing hippocampal neurogenesis via suppression of M1 microglial polarization and neuroinflammation in hypoxic-ischemic neonatal rats., PMID:38237226
For research use only. Not for human or drug use.
