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Anti-Human CD74 Antibody (SAA2015)

Catalog #:   RHC08001 Specific References (50) DATASHEET
Host species: Human
Isotype: IgG1, kappa
Applications: ELISA, WB
Accession: P04233
Overview

Catalog No.

RHC08001

Species reactivity

Human

Host species

Human

Isotype

IgG1, kappa

Clonality

Monoclonal

Target

HLA-DR antigens-associated invariant chain, HLA class II histocompatibility antigen gamma chain, CD74, CLIP, Ia antigen-associated invariant chain, DHLAG, Ii

Concentration

1 mg/ml

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

P04233

Applications

ELISA, WB

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Clone ID

SAA2015

Data Image
References

CX3CR1+ Monocytes/Macrophages Promote Regional Immune Injury in Mesangial Proliferative Glomerulonephritis through Crosstalk with Activated Mesangial Cells., PMID:40458609

MIF regulates T helper 17 cell differentiation by activating the p38 MAPK signaling pathway to drive the pathogenesis of EAP., PMID:40440956

Lysine-specific demethylase 1 deletion reshapes tumour microenvironment to overcome acquired resistance to anti-programmed death 1 therapy in liver cancer., PMID:40356247

Inhibition of MIF with an Allosteric Inhibitor Triggers Cell Cycle Arrest in Acute Myeloid Leukemia., PMID:40352549

Exploring the role of the CD74+ cardiac macrophage subset in trastuzumab cardiotoxicity and its mechanisms., PMID:40316056

Combination of anlotinib with immunotherapy enhanced both anti-angiogenesis and immune response in high-grade serous ovarian cancer., PMID:40260248

Transcriptomic signatures in peripheral CD4+T-lymphocytes may reflect melanoma staging and immunotherapy responsiveness prior to ICI initiation., PMID:40226614

Combination therapy with Chicoric acid and PD-1/PD-L1 blockade improves the immunotherapy response in patient-derived ovarian cancer xenograft model., PMID:40087780

Anti-CD74 autoantibodies in axial spondyloarthritis as biomarkers for activity and severity of disease but not for tumour necrosis factor inhibitor retention: data from the Swiss Clinical Quality Management in rheumatic diseases cohort., PMID:40063233

Preclinical in vitro and in vivo evidence for targeting CD74 as an effective treatment strategy for cutaneous T-cell lymphomas., PMID:40036608

System vaccinology analysis of predictors and mechanisms of antibody response durability to multiple vaccines in humans., PMID:39747435

Benzo (A) pyrene exposure alters alveolar epithelial and macrophage cells diversity and induces antioxidant responses in lungs., PMID:39506978

The VEGF-Mediated Cytoprotective Ability of MIF-Licensed Mesenchymal Stromal Cells in House Dust Mite-Induced Epithelial Damage., PMID:39502000

Potential protumor function of CD74 in clear cell renal cell carcinoma., PMID:39080216

Antibiotic use attenuates response to immune checkpoint blockade in urothelial carcinoma via inhibiting CD74-MIF/COPA: revealing cross-talk between anti-bacterial immunity and ant-itumor immunity., PMID:38995167

Redox-dependent plasticity of oxMIF facilitates its interaction with CD74 and therapeutic antibodies., PMID:38972295

Reconstituted CD74+ NK cells trigger chronic graft versus host disease after allogeneic bone marrow transplantation., PMID:38936148

The role of macrophage migration inhibitory factor family and CD74 in the pathogenesis of melanoma., PMID:38884501

Infliximab modifies CD74-mediated lymphatic abnormalities and adipose tissue alterations in creeping fat of Crohn's disease., PMID:38713235

MIF-Modulated Spinal Proteins Associated with Persistent Bladder Pain: A Proteomics Study., PMID:38674069

[Not Available]., PMID:38585235

Expert Consensus on the Diagnosis and Treatment of NRG1/2 Gene Fusion Solid Tumors., PMID:38414979

Granzyme B+ B cells detected by single-cell sequencing are associated with prognosis in patients with intrahepatic cholangiocarcinoma following liver transplantation., PMID:38386050

Year in Review in Axial Spondyloarthritis Clinical Research and Guidelines: SPARTAN 2023 Annual Meeting Proceedings., PMID:38340269

CD74 is associated with inflamed tumor immune microenvironment and predicts responsiveness to PD-1/CTLA-4 bispecific antibody in patients with solid tumors., PMID:38280003

Serum biomarkers and their relationship to axial spondyloarthritis associated with inflammatory bowel diseases., PMID:38168574

Extracellular macrophage migration inhibitory factor (MIF) downregulates adipose hormone-sensitive lipase (HSL) and contributes to obesity., PMID:37935315

Uncovering therapeutic opportunities in the clinical development of antibody-drug conjugates., PMID:37740463

A novel CAR-T cell product targeting CD74 is an effective therapeutic approach in preclinical mantle cell lymphoma models., PMID:37740214

Elevated Layilin-Positive Monocyte Levels in the Peripheral Blood of Patients with Systemic Lupus Erythematosus Reflect Their Autoimmune Status., PMID:37642473

Microglial CD68 and L-ferritin upregulation in response to phosphorylated-TDP-43 pathology in the amyotrophic lateral sclerosis brain., PMID:37118836

Migration inhibitory factor and cluster of differentiation 74-mediated dendritic cell apoptosis exacerbates acute acetaminophen-induced liver injury., PMID:37102665

Predictive value of CXCL10 for the occurrence of immune-related adverse events in patient with renal cell carcinoma., PMID:36975091

Single-cell analysis of human nasal mucosal IgE antibody secreting cells reveals a newly minted phenotype., PMID:36931600

Single-cell atlas of the immune microenvironment reveals macrophage reprogramming and the potential dual macrophage-targeted strategy in multiple myeloma., PMID:36852636

Diagnostic value of the anti-CD74 antibodies for axial spondyloarthritis: Results of a prospective study in patients with suspicious low back pain., PMID:36706946

Targeting CD74 in B-cell non-Hodgkin lymphoma with the antibody-drug conjugate STRO-001., PMID:36634212

OMIP-088: Twenty-target imaging mass cytometry panel for major cell populations in mouse formalin fixed paraffin embedded liver., PMID:36602064

Preclinical studies targeting CD74 with STRO-001 antibody-drug conjugate in acute leukemia., PMID:36595452

Exploring the potential molecular mechanism of trastuzumab-induced cardiotoxicity based on RNA sequencing and bioinformatics analysis., PMID:36563885

Single-cell multiomics revealed the dynamics of antigen presentation, immune response and T cell activation in the COVID-19 positive and recovered individuals., PMID:36532041

PD-L1 is required for estrogen-induced protection against severe EAE in IL-10 deficient mice1., PMID:36454506

Development of combinatorial antibody therapies for diffuse large B cell lymphoma., PMID:36353222

The first ADC bearing the ferroptosis inducer RSL3 as a payload with conservation of the fragile electrophilic warhead., PMID:36334452

Revised International Staging System (R-ISS) stage-dependent analysis uncovers oncogenes and potential immunotherapeutic targets in multiple myeloma (MM)., PMID:36315425

Identification of immune cell infiltration and diagnostic biomarkers in unstable atherosclerotic plaques by integrated bioinformatics analysis and machine learning., PMID:36211422

Distinct gene expression by expanded clones of quiescent memory CD4+ T cells harboring intact latent HIV-1 proviruses., PMID:36070690

Macrophage migration inhibitory factor (MIF) and IgA anti CD74 antibodies in Indian patients with enthesitis-related arthritis category of Juvenile idiopathic arthritis., PMID:35907018

Single-cell RNA Sequencing Analysis Reveals New Immune Disorder Complexities in Hypersplenism., PMID:35865544

Altered Circulating Immune Cell Distribution in Traumatic Spinal Cord Injury Patients in Relation to Clinical Parameters., PMID:35837411

Datasheet
$ 328
Product specifications
100 μg 328 1 mg 1640

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For research use only. Not for human or drug use.

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Anti-Human CD74 Antibody (SAA2015) [RHC08001]
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