Anti-Human CD175/Tn Antibody (KM3413)

Catalog No.

RHN10103

Species reactivity

Human

Host species

Mouse

Isotype

IgG2a, kappa

Clonality

Monoclonal

Target

Tn antigen saccharide, N-acetyl-α-D-galactosamine, GalNAcα1-O-Ser/Thr/Tyr

Concentration

1 mg/ml

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Applications

ELISA

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Clone ID

KM3413

Anti-GalNAcα (anti-Tn) antibody repertoire differs between individuals with blood groups A and B., PMID:40285953

Advancing Non-Invasive Colorectal Cancer Screening: Exploring the Potential of Monoclonal Antibody L2A5., PMID:40243708

Structure of the Fab fragment of a humanized 5E5 antibody to a cancer-specific Tn-MUC1 epitope., PMID:40221891

Development, Characterization, and Evaluation of Chi-Tn mAb-Functionalized DOTAP-PLGA Hybrid Nanoparticles Loaded with Docetaxel for Lung Cancer Therapy., PMID:40006531

Differential expression of CD175 and CA19-9 in pancreatic adenocarcinoma., PMID:39905057

Decoding the Molecular Basis of the Specificity of an Anti-sTn Antibody., PMID:39886580

ST6GALNAC1-mediated sialylation in uterine endometrial epithelium facilitates the epithelium-embryo attachment., PMID:39111624

Lymph Node Targeting Mediated by Albumin Hitchhiking of Synthetic Tn Glycolipid Leads to Robust In Vivo Antibody Production., PMID:38533876

A Comprehensive Analysis of Tn and STn Antigen Expression in Esophageal Adenocarcinoma., PMID:38254730

Identification of the glycopeptide epitope recognized by a protective Cryptosporidium monoclonal antibody., PMID:37725059

Tiliroside Combined with Anti-MUC1 Monoclonal Antibody as Promising Anti-Cancer Strategy in AGS Cancer Cells., PMID:37685842

Nanoparticles targeting Sialyl-Tn for efficient tyrosine kinase inhibitor delivery in gastric cancer., PMID:37586448

Aberrant Glycosylation as Immune Therapeutic Targets for Solid Tumors., PMID:37509200

A synthetic Tn-BSA conjugate vaccine bearing chitotriose as built-in adjuvant., PMID:37348181

MUC1 Glycopeptide Vaccine Modified with a GalNAc Glycocluster Targets the Macrophage Galactose C-type Lectin on Dendritic Cells to Elicit an Improved Humoral Response., PMID:37279388

Single CAR-T cell treatment controls disseminated ovarian cancer in a syngeneic mouse model., PMID:37258040

Targeting altered glycosylation in secreted tumor glycoproteins for broad cancer detection., PMID:37216646

Targeting Tn-positive tumors with an afucosylated recombinant anti-Tn IgG., PMID:36977722

Association of Sialyl Tn antigen with cervical cancer lymph node status: An NRG oncology/GOG study., PMID:36827840

How to choose proper magnetic particles for bioaffinity interactions? The case for immobilised glyconanoconjugate., PMID:36657889

Evaluation of serum CA125-Tn glycoform in peritoneal dissemination and surgical completeness of high-grade serous ovarian cancer., PMID:36564848

Fully synthetic Tn-based three-component cancer vaccine using covalently linked TLR4 ligand MPLA and iNKT cell agonist KRN-7000 as built-in adjuvant effectively protects mice from tumor development., PMID:36561989

Immunohistochemical analysis of Tn antigen expression in colorectal adenocarcinoma and precursor lesions., PMID:36476111

Identification and characterization of circulating immune complexes in IgA nephropathy., PMID:36306365

Polymeric nanoparticles targeting Sialyl-Tn in gastric cancer: A live tracking under flow conditions., PMID:36105678

Liposome-Based Carbohydrate Vaccine for Simultaneously Eliciting Humoral and Cellular Antitumor Immunity., PMID:35833848

A case of Tn polyagglutination discovered by an ABO blood group discrepancy., PMID:35748659

Structurally Constrained MUC1-Tn Mimetic Antigen as Template for Molecularly Imprinted Polymers (MIPs): A Promising Tool for Cancer Diagnostics., PMID:35502851

Selective Recognition of Carbohydrate Antigens by Germline Antibodies Isolated from AID Knockout Mice., PMID:35282679

Anti-Tn Monoclonal Antibody Ameliorates Hyperoxia-Induced Kidney Injury by Suppressing Oxidative Stress and Inflammation in Neonatal Mice., PMID:34720748

Design, synthesis, and initial immunological evaluation of glycoconjugates based on saponin adjuvants and the Tn antigen., PMID:34647563

A glycan-based plasmonic sensor for prostate cancer diagnosis., PMID:34623365

Mapping of truncated O-glycans in cancers of epithelial and non-epithelial origin., PMID:34526666

Structure-based Design of Anti-cancer Vaccines: The Significance of Antigen Presentation to Boost the Immune Response., PMID:34375180

CA125-Tn ELISA assay improves specificity of pre-operative diagnosis of ovarian cancer among patients with elevated serum CA125 levels., PMID:34268401

The Tn antigen promotes lung tumor growth by fostering immunosuppression and angiogenesis via interaction with Macrophage Galactose-type lectin 2 (MGL2)., PMID:34144098

Docetaxel in chitosan-based nanocapsules conjugated with an anti-Tn antigen mouse/human chimeric antibody as a promising targeting strategy of lung tumors., PMID:33857513

A biotechnological tool for glycoprotein desialylation based on immobilized neuraminidase from Clostridium perfringens., PMID:33732900

Low Levels of Natural Anti-α-N-Acetylgalactosamine (Tn) Antibodies Are Associated With COVID-19., PMID:33643275

A novel Tn antigen epitope-recognizing antibody for MUC1 predicts clinical outcome in patients with primary lung adenocarcinoma., PMID:33574941

Rhamnose modified bovine serum albumin as a carrier protein promotes the immune response against sTn antigen., PMID:33079080

CD44-Associated Tn Antigen as a New Biomarker of Tumor Cells with Aberrant Glycosylation., PMID:33050853

Synthesis of MUC1-derived glycopeptide bearing a novel triazole STn analog., PMID:33010570

Shigella flexneri Targets Human Colonic Goblet Cells by O Antigen Binding to Sialyl-Tn and Tn Antigens via Glycan-Glycan Interactions., PMID:32926786

Production of a Granulysin-Based, Tn-Targeted Cytolytic Immunotoxin Using Pulsed Electric Field Technology., PMID:32859066

Engineering orthogonal human O-linked glycoprotein biosynthesis in bacteria., PMID:32719555

Amplified Detection of Breast Cancer Autoantibodies Using MUC1-Based Tn Antigen Mimics., PMID:32672464

A Structurally Simple Vaccine Candidate Reduces Progression and Dissemination of Triple-Negative Breast Cancer., PMID:32629615

Structure-guided engineering of the affinity and specificity of CARs against Tn-glycopeptides., PMID:32541028

Siglec-15 recognition of sialoglycans on tumor cell lines can occur independently of sialyl Tn antigen expression., PMID:32501471

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