Anti-763.74 Monoclonal Antibody (MK2-23)

Catalog No.

RAJ08301

Host species

Mouse

Isotype

IgG2a

Clonality

Monoclonal

Target

HMW-MAA mimicry, Anti-Human CSPG4/HMW-MAA/MCSP/NG2 Antibody clone 763.74#, Idiotypic antibody

Concentration

1 mg/ml

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

Q6UVK1

Applications

ELISA

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Clone ID

MK2-23

Clinical Management of Persistent Hypereosinophilia., PMID:39961601

Plasma Human Immunodeficiency Virus 1 Soluble Glycoprotein 120 Association With Correlates of Immune Dysfunction and Inflammation in Antiretroviral Therapy-Treated Individuals With Undetectable Viremia., PMID:38035854

World human neutrophil antigens investigation survey., PMID:37608544

Safety, tolerability, pharmacokinetics and immunogenicity of an antibody-drug conjugate (SHR-A1201) in patients with HER2-positive advanced breast cancer: an open, phase I dose-escalation study., PMID:36730296

First-hand knowledge about snakes and snake-bite management: an urgent need., PMID:33311806

Au23(CR)14 nanocluster restores fibril Aβ's unfolded state with abolished cytotoxicity and dissolves endogenous Aβ plaques., PMID:34692095

The HIV-1 Entry Process: A Stoichiometric View., PMID:26541228

Necitumumab plus gemcitabine and cisplatin versus gemcitabine and cisplatin alone as first-line therapy in patients with stage IV squamous non-small-cell lung cancer (SQUIRE): an open-label, randomised, controlled phase 3 trial., PMID:26045340

Genetic surface-display of methyl parathion hydrolase on Yarrowia lipolytica for removal of methyl parathion in water., PMID:22534797

Ketohexokinase: expression and localization of the principal fructose-metabolizing enzyme., PMID:19365088

Odorant responsiveness of squid olfactory receptor neurons., PMID:18484602

Targeting melanoma cells with human high molecular weight-melanoma associated antigen-specific antibodies elicited by a peptide mimotope: functional effects., PMID:16670313

Human high molecular weight melanoma-associated antigen mimicry by mouse anti-idiotypic monoclonal antibody MK2-23: enhancement of immunogenicity of anti-idiotypic monoclonal antibody MK2-23 by fusion with interleukin 2., PMID:16061683

Differential immunogenicity of two peptides isolated by high molecular weight-melanoma-associated antigen-specific monoclonal antibodies with different affinities., PMID:15905554

Specific lysis of melanoma cells by receptor grafted T cells is enhanced by anti-idiotypic monoclonal antibodies directed to the scFv domain of the receptor., PMID:10233766

Identification of the human melanoma-associated chondroitin sulfate proteoglycan antigen epitope recognized by the antitumor monoclonal antibody 763.74 from a peptide phage library., PMID:10029083

Improved tumor targeting of rhenium-186-labeled anti-human high-m.w. melanoma-associated antigen monoclonal antibody 763.74 following purification with anti-idiotypic monoclonal antibody MK2-23., PMID:9797138

Titration calorimetry study of an anti-idiotypic antibody cascade in a human melanoma-associated antigen system., PMID:9430197

Purification by affinity chromatography with anti-idiotypic monoclonal antibodies of immunoreactive monoclonal antibodies following labeling with 188Re., PMID:9085125

Crystal structure of an anti-anti-idiotype shows it to be self-complementary., PMID:8568901

Human high molecular weight-melanoma associated antigen mimicry by mouse anti-idiotypic monoclonal antibody MK2-23: modulation of the immunogenicity in patients with malignant melanoma., PMID:9816036

Antiantiidiotypic response and clinical course of the disease in patients with malignant melanoma immunized with mouse antiidiotypic monoclonal antibody MK2-23., PMID:7590776

Human high molecular weight-melanoma associated antigen mimicry by mouse anti-idiotypic MAb MK2-23. Immunohistochemical analysis of the reactivity of anti-anti-idiotypic MAb with surgically removed melanoma lesions., PMID:7829240

Idiotypic cascade in the human high molecular weight melanoma-associated antigen system: fine specificity and idiotypic profile of anti-anti-idiotypic monoclonal antibodies., PMID:7686858

Lymphotoxin is an autocrine growth factor for Epstein-Barr virus-infected B cell lines., PMID:8382256

Human high molecular weight-melanoma associated antigen mimicry by mouse anti-idiotypic monoclonal antibodies MK2-23. Experimental studies and clinical trials in patients with malignant melanoma., PMID:8361995

Modulation by adjuvants and carriers of the immunogenicity in xenogeneic hosts of mouse anti-idiotypic monoclonal antibody MK2-23, an internal image of human high molecular weight-melanoma associated antigen., PMID:8416734

Binding parameters and idiotypic profile of the whole immunoglobulin and Fab' fragments of murine monoclonal antibody to distinct determinants of the human high molecular weight-melanoma associated antigen., PMID:1373670

Human high molecular weight melanoma-associated antigen (HMW-MAA) mimicry by mouse anti-idiotypic monoclonal antibody MK2-23: induction of humoral anti-HMW-MAA immunity and prolongation of survival in patients with stage IV melanoma., PMID:1731316

Characterization of the major allergen of Cynodon dactylon (Bermuda grass) pollen, Cyn d I., PMID:1955635

Human high molecular weight melanoma-associated antigen mimicry by mouse antiidiotypic monoclonal antibody MK2-23. Characterization of the immunogenicity in syngeneic hosts., PMID:1861071

Expression patterns of the T antigen and the cryptic T antigen in rat fetuses: detection with the lectin amaranthin., PMID:2335739

Characterization of syngeneic antiidiotypic monoclonal antibodies to murine anti-human high molecular weight melanoma-associated antigen monoclonal antibodies., PMID:2584721

Analysis of the antigenic profile of uveal melanoma lesions with anti-cutaneous melanoma-associated antigen and anti-HLA monoclonal antibodies., PMID:2917356

Melanoma targeting with a cocktail of monoclonal antibodies to distinct determinants of the human HMW-MAA., PMID:2472474

Superficial spreading melanoma with a nodular area: antigenic phenotype of the radial and vertical growth areas., PMID:2711482

Antigenic phenotype of radial growth phase melanomas with or without a vertical growth phase portion., PMID:3285554

Syngeneic antiidiotypic antisera to murine antihuman high-molecular-weight melanoma-associated antigen monoclonal antibodies., PMID:3607764

Ribonuclease-sensitive ribosomal vaccines., PMID:6084981

Biosynthesis of Rauscher leukemia viral proteins: presence of p30 and envelope p15 sequences in precursor polypeptides., PMID:1258368

[Chronic monocytosis--its relationship with leukemia]., PMID:4506235

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