Catalog No.
PHJ89301
Species reactivity
Human, Mouse, Rat
Host species
Rabbit
Isotype
IgG
Clonality
Polyclonal
Immunogen
E. coli - derived recombinant Human CD2AP (Val2-Lys58).
Tested applications
ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000
Target
CD2-associated protein, Adapter protein CMS, Cas ligand with multiple SH3 domains, CD2AP
Purification
Purified by antigen affinity column.
Accession
Q9Y5K6
Applications
ELISA, IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
CD2AP is Co-Expressed with Tropomyosin-Related Kinase A and Ras-Related Protein Rab-5A in Cholinergic Neurons of the Murine Basal Forebrain., PMID:39211110
Minnelide combined with anti-ANGPTL3-FLD monoclonal antibody completely protects mice with adriamycin nephropathy by promoting autophagy and inhibiting apoptosis., PMID:37689694
Genomics of Alzheimer's disease implicates the innate and adaptive immune systems., PMID:34708251
MicroRNA-548k upregulates a spliced variant of human CD2-associated protein by targeting its promoter., PMID:32608582
Tyrosine Phosphorylation of CD2AP Affects Stability of the Slit Diaphragm Complex., PMID:31235616
The adaptor molecule CD2AP in CD4 T cells modulates differentiation of follicular helper T cells during chronic LCMV infection., PMID:29734372
Urinary podocyte-associated molecules and albuminuria in hypertension., PMID:29677049
Inhibition of SHIP2 in CD2AP-deficient podocytes ameliorates reactive oxygen species generation but aggravates apoptosis., PMID:28878342
NF-κB-dependent increase in tissue factor expression is responsible for hypoxic podocyte injury., PMID:26715508
Focal segmental glomerulosclerosis: molecular genetics and targeted therapies., PMID:26156092
Reticular erythematous mucinosis: histopathological and immunohistochemical features of 25 patients compared with 25 cases of lupus erythematosus tumidus., PMID:25087914
Close relations between podocyte injuries and membranous proliferative glomerulonephritis in autoimmune murine models., PMID:23817053
Expression of the CD2AP adaptor molecule in normal, reactive and neoplastic human tissue., PMID:22953501
Alzheimer's Disease: APP, Gamma Secretase, APOE, CLU, CR1, PICALM, ABCA7, BIN1, CD2AP, CD33, EPHA1, and MS4A2, and Their Relationships with Herpes Simplex, C. Pneumoniae, Other Suspect Pathogens, and the Immune System., PMID:22254144
Plasmacytoid dendritic cells: an overview of their presence and distribution in different inflammatory skin diseases, with special emphasis on Jessner's lymphocytic infiltrate of the skin and cutaneous lupus erythematosus., PMID:20659210
CIN85/RukL is a novel binding partner of nephrin and podocin and mediates slit diaphragm turnover in podocytes., PMID:20457601
[New functional proteins identified by proteomic analysis in the epidermal growth factor receptor-mediated signaling pathway and application for practical use]., PMID:20371988
Slit diaphragm dysfunction in proteinuric states: identification of novel therapeutic targets for nephrotic syndrome., PMID:19266252
The insect nephrocyte is a podocyte-like cell with a filtration slit diaphragm., PMID:18971929
Dissociation of NEPH1 from nephrin is involved in development of a rat model of focal segmental glomerulosclerosis., PMID:18715943
Adaptor protein Ruk/CIN85 is associated with a subset of COPI-coated membranes of the Golgi complex., PMID:18266907
Ephrin-B1 localizes at the slit diaphragm of the glomerular podocyte., PMID:17667985
Nuclear relocation of the nephrin and CD2AP-binding protein dendrin promotes apoptosis of podocytes., PMID:17537921
Expression of adaptor protein Ruk/CIN85 isoforms in cell lines of various tissue origins and human melanoma., PMID:17285110
Synaptic vesicle protein 2B is expressed in podocyte, and its expression is altered in proteinuric glomeruli., PMID:16943307
Role of podocyte slit diaphragm as a filtration barrier., PMID:16889564
Podocyte-associated proteins FAT, alpha-actinin-4 and filtrin are expressed in Langerhans islets of the pancreas., PMID:16841182
Autocrine VEGF-A system in podocytes regulates podocin and its interaction with CD2AP., PMID:16597608
Nephrin and podocin dissociate at the onset of proteinuria in experimental membranous nephropathy., PMID:15882266
Clues to CD2-associated protein involvement in cytokinesis., PMID:15800069
CD2-associated protein in human urogenital system and in adult kidney tumours., PMID:15785926
Nephrin expression is increased in anti-Thy1.1-induced glomerulonephritis in rats., PMID:15465010
In vivo expression of podocyte slit diaphragm-associated proteins in nephrotic patients with NPHS2 mutation., PMID:15327385
A novel role for the adaptor molecule CD2-associated protein in transforming growth factor-beta-induced apoptosis., PMID:15213232
Podocyte migration during nephrotic syndrome requires a coordinated interplay between cathepsin L and alpha3 integrin., PMID:15197181
Nephrin promotes cell-cell adhesion through homophilic interactions., PMID:14633607
Podocyte changes upon induction of albuminuria in Thy-1.1 transgenic mice., PMID:14605274
Podocyte changes after induction of acute albuminuria in mice by anti-aminopeptidase A mAb., PMID:12902618
Targeted downregulation of extracellular nephrin in human IgA nephropathy., PMID:12853730
In vivo expression of putative LMX1B targets in nail-patella syndrome kidneys., PMID:12819019
CD2-associated protein haploinsufficiency is linked to glomerular disease susceptibility., PMID:12764198
A Cortactin-CD2-associated protein (CD2AP) complex provides a novel link between epidermal growth factor receptor endocytosis and the actin cytoskeleton., PMID:12672817
Transcriptional induction of slit diaphragm genes by Lmx1b is required in podocyte differentiation., PMID:11956244
Nephrin dissociates from actin, and its expression is reduced in early experimental membranous nephropathy., PMID:11912254
CD2AP and p130Cas localize to different F-actin structures in podocytes., PMID:11553524
Preliminary findings of chromosomal alterations and expression of cell cycle genes in head an neck tumors., PMID:11894785
For research use only. Not for human or drug use.
