Catalog No.
PHJ77701
Species reactivity
Human, Mouse, Rat
Host species
Rabbit
Isotype
IgG
Clonality
Polyclonal
Immunogen
E. coli - derived recombinant Human TMEFF2 (Lys75-Gly133).
Tested applications
ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000
Target
Transmembrane protein with EGF-like and two follistatin-like domains, TENB2, Hyperplastic polyposis protein 1, TR-2, HPP1, TMEFF2, TPEF, Tomoregulin-2
Purification
Purified by antigen affinity column.
Accession
Q9UIK5
Applications
ELISA, IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
A first-in-human study of JNJ-70218902, a bispecific T-cell-redirecting antibody against TMEFF2 in metastatic castration-resistant prostate cancer., PMID:39832129
Methylated free-circulating HPP1 DNA is an early response marker in patients with metastatic colorectal cancer., PMID:28124380
ImmunoPET helps predicting the efficacy of antibody-drug conjugates targeting TENB2 and STEAP1., PMID:27029064
Tomoregulin (TMEFF2) Binds Alzheimer's Disease Amyloid-β (Aβ) Oligomer and AβPP and Protects Neurons from Aβ-Induced Toxicity., PMID:26402097
The TMEFF2 tumor suppressor modulates integrin expression, RhoA activation and migration of prostate cancer cells., PMID:24632071
Anti-tumor efficacy of chitosan-g-poly(ethylene glycol) nanocapsules containing docetaxel: anti-TMEFF-2 functionalized nanocapsules vs. non-functionalized nanocapsules., PMID:23262164
An integrated approach to identify normal tissue expression of targets for antibody-drug conjugates: case study of TENB2., PMID:22889168
Differential effects of predosing on tumor and tissue uptake of an 111In-labeled anti-TENB2 antibody-drug conjugate., PMID:22872740
Obligate multivalent recognition of cell surface tomoregulin following selection from a multivalent phage antibody library., PMID:17092910
Induction of apoptosis in hematopoietic cells with an antibody against tomoregulin-1., PMID:16475715
Targeting tomoregulin for radioimmunotherapy of prostate cancer., PMID:15805286
Preclinical validation of anti-TMEFF2-auristatin E-conjugated antibodies in the treatment of prostate cancer., PMID:15299075
For research use only. Not for human or drug use.
