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Anti-JAK3 Polyclonal Antibody

Catalog #:   PHE91801 Specific References (50) DATASHEET
Host species: Rabbit
Isotype: IgG
Applications: ELISA, IHC, WB
Accession: P52333
Overview

Catalog No.

PHE91801

Species reactivity

Human, Mouse, Rat

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human JAK3 (Gly46-Thr209).

Tested applications

ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000

Target

L-JAK,Janus kinase 3,Leukocyte janus kinase,JAK-3,Tyrosine-protein kinase JAK3,JAK3

Purification

Purified by antigen affinity column.

Accession

P52333

Applications

ELISA, IHC, WB

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Data Image
  • WESTERN BLOT
    Recombinant Protein lysates were subjected to SDS PAGE followed by western blot with JAK3 antibody (PHE91801) at 1 μg/ml.

    Lane 1: Recombinant protein

    Second Ab: Goat Anti-Rabbit IgG H&L Polyclonal antibody, HRP (PTB96431) at 0.1 μg/mL.

    Predict MW: 21 kDa
    Observed MW: 21 kDa
References

Biological and Clinical Relevance of Genetic Alterations in Peripheral T-cell Lymphomas., PMID:40416001

JAK3 A573V and JAK3 M511I mutations in peripheral T-cell lymphoma mediating resistance to anti-PD-1 therapy through the STAT3/PD-L1 pathway., PMID:40199606

Modulating IL-21-driven B cell responses in idiopathic inflammatory myopathies via inhibition of the JAK/STAT pathway., PMID:40170058

Interaction between interleukin-12 (IL-12) and its receptor (IL-12Rβ2) mediates CD4+ T cell subsets activation in flounder (Paralichthys olivaceus)., PMID:39743087

The Innate Immune System Surveillance Biomarker p87 in African Americans and Caucasians with Small High-Grade Dysplastic Adenoma [SHiGDA] and Right-Sided JAK3 Colon Mutations May Explain the Presence of Multiple Cancers Revealing an Important Minority of Patients with JAK3 Mutations and Colorectal Neoplasia., PMID:39507544

Genes deregulated in giant cell arteritis by Nanostring nCounter gene expression profiling in temporal artery biopsies., PMID:39317454

The JAK1/JAK2 inhibitor ruxolitinib inhibits mediator release from human basophils and mast cells., PMID:39188724

Omenn Syndrome in Two Infants with Different Hypomorphic Variants in Janus Kinase 3., PMID:38598033

Effectiveness of tofacitinib monotherapy for patients with IgG4-RD or idiopathic retroperitoneal fibrosis., PMID:38530663

Radical S-adenosyl methionine domain-containing 2, a potential target of D-tryptophan in asthma treatment, regulates T helper cell type 1/2 balance., PMID:38310765

Suppression of NK Cell Activation by JAK3 Inhibition: Implication in the Treatment of Autoimmune Diseases., PMID:38106519

JAK3 Y841 Autophosphorylation Is Critical for STAT5B Activation, Kinase Domain Stability and Dimer Formation., PMID:37569303

A novel cDNA-uPA/SCID/Rag2-/- /Jak3-/- mouse model for hepatitis virus infection and reconstruction of human immune system., PMID:36575861

CXCL16 inhibits epithelial regeneration and promotes fibrosis during the progression of radiation enteritis., PMID:36373877

CS12192, a Novel JAK3/JAK1/TBK1 Inhibitor, Synergistically Enhances the Anti-Inflammation Effect of Methotrexate in a Rat Model of Rheumatoid Arthritis., PMID:36362183

IL-7: Comprehensive review., PMID:36201890

Clinicopathologic and Genomic Features in Triple-Negative Breast Cancer Between Special and No-Special Morphologic Pattern., PMID:35402236

A novel intramolecular negative regulation of mouse Jak3 activity by tyrosine 820., PMID:35192696

Tumor necrosis factor alpha neutralization attenuates immune checkpoint inhibitor-induced activation of intermediate monocytes in synovial fluid mononuclear cells from patients with inflammatory arthritis., PMID:35164829

Defects in mucosal immunity and nasopharyngeal dysbiosis in HSC-transplanted SCID patients with IL2RG/JAK3 deficiency., PMID:35157765

T Cell Repertoire Abnormality in Immunodeficiency Patients with DNA Repair and Methylation Defects., PMID:34825286

Immune cells surveil aberrantly sialylated O-glycans on megakaryocytes to regulate platelet count., PMID:34324649

Anti-IL-23 exerted protective effects on cerebral ischemia-reperfusion injury through JAK2/STAT3 signaling pathway., PMID:33904141

Recurrent Chronic HEV in Severe Combined Immunodeficiency., PMID:33619683

Upadacitinib in Rheumatoid Arthritis: A Benefit-Risk Assessment Across a Phase III Program., PMID:33527177

Qingxue jiedu formulation ameliorated DNFB-induced atopic dermatitis by inhibiting STAT3/MAPK/NF-κB signaling pathways., PMID:33388430

Combination of anti-PD-1 antibody with P-GEMOX as a potentially effective immunochemotherapy for advanced natural killer/T cell lymphoma., PMID:33376237

Increased expression of interleukin-21-inducible genes in minor salivary glands are associated with primary Sjögren's syndrome disease characteristics., PMID:33247940

Deep phenotyping of synovial molecular signatures by integrative systems analysis in rheumatoid arthritis., PMID:33230538

Molecular basis and therapeutic implications of CD40/CD40L immune checkpoint., PMID:33091428

The Natural Compound Notopterol Binds and Targets JAK2/3 to Ameliorate Inflammation and Arthritis., PMID:32937124

Efficacy and Safety of PF-06651600 (Ritlecitinib), a Novel JAK3/TEC Inhibitor, in Patients With Moderate-to-Severe Rheumatoid Arthritis and an Inadequate Response to Methotrexate., PMID:32419304

Ulcerative colitis: understanding its cellular pathology could provide insights into novel therapies., PMID:32336953

Monozygotic Twins Concordant for Common Variable Immunodeficiency: Strikingly Similar Clinical and Immune Profile Associated With a Polygenic Burden., PMID:31824477

Autocrine Production of Interleukin-34 Promotes the Development of Endometriosis through CSF1R/JAK3/STAT6 signaling., PMID:31727934

Targeted blockade of interleukin 9 inhibits tumor growth in murine model of pancreatic cancer., PMID:31647203

Therapeutic treatment of a novel selective JAK3/JAK1/TBK1 inhibitor, CS12192, in rat and mouse models of rheumatoid arthritis., PMID:31634789

IL-7-Mediated IL-7R-JAK3/STAT5 signalling pathway contributes to chemotherapeutic sensitivity in non-small-cell lung cancer., PMID:31599032

IL-2 receptors preassemble and signal in the ER/Golgi causing resistance to antiproliferative anti-IL-2Rα therapies., PMID:31570576

Assessment of the genes and molecular mechanisms of B cells activation through systems biology approaches., PMID:31524152

The γc Family of Cytokines: Basic Biology to Therapeutic Ramifications., PMID:30995502

Tumor-specific delivery of therapeutic siRNAs by anti-EGFR immunonanoparticles., PMID:30214190

Oncogenic activation of the STAT3 pathway drives PD-L1 expression in natural killer/T-cell lymphoma., PMID:30054295

Tofacitinib Halts Progression of Graft Dysfunction in a Rat Model of Mixed Cellular and Humoral Rejection., PMID:29620612

ILC2 frequency and activity are inhibited by glucocorticoid treatment via STAT pathway in patients with asthma., PMID:29542140

[Emerging Therapies: What Are Promising in the Near Future?]., PMID:29471605

Immunologic effects of chronic administration of tofacitinib, a Janus kinase inhibitor, in cynomolgus monkeys and rats - Comparison of juvenile and adult responses., PMID:29454012

Advances in the understanding and management of T-cell prolymphocytic leukemia., PMID:29262669

STAT5B: A Differential Regulator of the Life and Death of CD4+ Effector Memory T Cells., PMID:29187589

A gene module associated with dysregulated TCR signaling pathways in CD4+ T cell subsets in rheumatoid arthritis., PMID:29146547

Datasheet
$ 170
Product specifications
50 μg 170 100 μg 280

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For research use only. Not for human or drug use.

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Anti-JAK3 Polyclonal Antibody [PHE91801]
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